**2. Literature research strategy**

We searched PubMed from 1968 to January 2021 with the words "Moyamoya disease", "Moyamoya syndrome", "population-based", "epidemiology", "risk factors", "genetics", "clinical aspects",clinical features of Moyamoya, seizure and Moyamoya, headache and Moyamoya, paediatric Moyamoya, Adult Moyamoya, stroke and Moyamoya, neuropsychological profile of Moyamoya, Research studies on Moyamoya, Case reports of Moyamoya. Relevant articles were also searched in the national and International journals where the full article could be retrieved. Clinical manifestation and underlying pathophysiology was reviewed in the searched article to provide an extensive review ofclinical aspects of Moyamoya disease.
