**2. Methods used**

A literature search was conducted using PubMed. The keywords used were Moyamoya disease, Moyamoya syndrome, 'puff of smoke', Suzuki classification, angiography, revascularization procedures etc. Relevant articles were reviewed in detail. The search was filtered to include as many recent publications as possible. An effort was made to compile and highlight the key differences in the disease's clinical profile from East to West.
