**2.2 Etiopathogenesis**

Moyamoya disease has a genetic aetiology, as mentioned above. Many studies where total genome search linkage was performed found an association between the disease and markers located at 3p24.2–26 chromosome [7], a possible connection of the marker D6S441 located on chromosome 6 which also has HLA gene [8], linkage to chromosome 17 have also been reported.

Moyamoya syndrome is associated with many conditions, as described below: [8].


A role of fibroblast growth factor, prostaglandin, and activation of cox2 in the vascular smooth muscle, EBV DNA and propionibacteria have all been proposed as a possible mediator of the neovascular response [9].
