**Author details**

*Cytogenetics - Classical and Molecular Strategies for Analysing Heredity Material*

proteins have made it possible to specify the nature of the molecular events result-

*Schema the Philadelphia chromosome t(9;22)(q34;q11) results in the fusion of* BCR *genes on chromosome 22 and* ABL *on chromosome 22. The fusion protein has a strong activity tyrosine kinase responsible for tumor* 

Fluorescent in situ hybridization (FISH) using specific probes provides a useful tool for the detection of t(9;22)(q34;q11) and *BCR-ABL* rearrangement [16] (**Figure 3**). The fusion protein has a strong activity tyrosine kinase responsible for

In summary, Philadelphia chromosome is an abnormal chromosome 22, resulting from a reciprocal translocation between chromosomes 9 and 22, a specific marker in chronic myeloid leukemia. His research in myeloproliferative syndromes has multiple interests: Diagnostic, prognostic and therapeutic follow-up which contributes to better patient care. Its demonstration in myeloproliferative syndromes makes it possible to confirm the nature of the disease and to distinguish

The authors would like to thank the patients and their family. We are grateful to all of the staff of the Department of Medical Genetics of the National Institute of

ing from the rearrangement of *BCR-ABL* (**Table 2**)**.**

between CM and other myeloproliferative syndromes.

tumor development (**Figure 5**)**.**

**7. Conclusion**

**Figure 5.**

*development.*

**Acknowledgements**

**List of abbreviations**

Ph Philadelphia

Health for their continuous support.

CML chronic myeloid leukemia CML

ALL acute lymphoblastic leukemia LAM acute myeloid leukemia type 1 LAL1 acute lymphoblastic leukemia type 1 ALL acute lymphoblastic leukemia AML acute myeloid leukemia

CMML chronic myelomonocyte leukemia MPS myeloproliferative syndromes

**136**

Yahya Benbouchta1,2\*, Ahmed Afailal Tribak2 and Khalid Sadki<sup>2</sup>

1 Department of Medical Genetics, National Institute of Health, Rabat, Morocco

2 Laboratory of Human Pathology, Faculty of Sciences, Mohammed V University in Rabat, Morocco

\*Address all correspondence to: benbouchtayahya@yahoo.fr

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