**Author details**

Xiangli Niu1 , Yanping Lao1 , Yan Sun1 and Weihua Wang2 \*

1 Research Center for Reproductive Medicine, Reproductive Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China

2 Houston Fertility Laboratory, Houston, TX, USA

\*Address all correspondence to: wangweihua11@yahoo.com

© 2020 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/ by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

**85**

638-643.

*Next-Generation Sequencing Revealed that High Proportion of Human Embryos Resulted…*

analysis of genetic error observed in 305 embryos derived from anonymous donor oocyte IVF cycles. Mol Cytogenet

[9] Haddad G, Deng M, Wang CT, Witz C, Williams D, Griffith J, Skorupski J, Gill J, Wang W-H. Assessment of aneuploidy formation in human blastocysts resulting from donated eggs and the necessity of the embryos for aneuploidy screening. J Assist Reprod Genet 2015; 32:

[10] Franasiak JM, Forman EJ, Hong KH, Werner MD, Upham KM, Treff NR,Scott RT. The nature of aneuploidy with increasing age of the female partner: a review of 15,169 consecutive trophectoderm biopsies evaluated with comprehensive chromosomal screening. Fertil Steril

[11] Milán M, Cobo AC, Rodrigo L, Mateu E, Mercader A, Buendía P, Peinado V, Delgado A, Mir P,

Simón C, Remohí J, Pellicer A, Rubio C. Redefining advanced maternal age as an indication for preimplantation genetic screening. Reprod Biomed Online 2010;

[12] Munné S, Alikani M, Ribustello L,

McCulloh DH. Euploidy rates in donor egg cycles significantly differ between fertility centers. Hum Reprod 2017; 32:

Colls P, Martínez-Ortiz PA,

[13] Staessen C, Platteau P, Van Assche E, Michiels A, Tournaye H, Camus M, Devroey P, Liebaers I, Van Steirteghem A. Comparison of blastocyst transfer with or without preimplantation genetic diagnosis for aneuploidy screening in couples with advanced maternal age: a prospective randomized controlled trial. Hum Reprod 2004; 19: 2849-2858.

2014; 101: 656-663.

21: 649-657.

743-749.

2014; 7: 68.

999-1006.

*DOI: http://dx.doi.org/10.5772/intechopen.95457*

[1] Wang WH, Sun QY. Meiotic spindle, spindle checkpoint and embryonic aneuploidy. Front Biosci 2006; 11:

[2] Jones KT. Meiosis in oocytes: predisposition to aneuploidy and its increased incidence with age. Hum Reprod Update 2008; 14:143-158.

[3] Hassold T, Hunt P. To err

(meiotically) is human: the genesis of human aneuploidy. Nat Rev Genet 2001;

[4] Liang L, Wang CT, Sun X, Liu L, Li M, Witz C, Williams D, Griffith J, Skorupski J, Haddad G, Gill J, Wang WH. Identification of chromosomal errors in human preimplantation embryos with oligonucleotide DNA microarray. PLoS

[6] Yang Z, Liu J, Collins GS, Salem SA, Liu X, Lyle SS, Peck AC, Sills ES,

Salem RD. Selection of single blastocysts

morphology assessment alone and with array CGH for good prognosis IVF patients, results from a randomized pilot study. Mol Cytogenet 2012; 5: 24.

[7] Munné S, Sandalinas M, Magli C, Gianaroli L, Cohen J, Warburton D. Increased rate of aneuploid embryos in young women with previous aneuploid conceptions. Prenatal Diagn 2004; 24:

[8] Sills ES, Li X, Frederick JL, Khoury CD, Potter DA. Determining parental origin of embryo aneuploidy:

for fresh transfer via standard

**References**

620-636.

2: 280-291.

One 2013; 8: e61838.

[5] Baart EB, Martini E, van den Berg I, Macklon NS, Galjaard RJH, Fauser BCJM, Van Opstal D. Preimplantation genetic screening reveals a high incidence of aneuploidy and mosaicism in embryos from young women undergoing IVF. Hum Reprod 2006; 21: 223-233.

*Next-Generation Sequencing Revealed that High Proportion of Human Embryos Resulted… DOI: http://dx.doi.org/10.5772/intechopen.95457*
