**5.5 17p-/-17 and TP53 mutations**

Abnormalities of chromosome 17 are multiple, it can be deletion, monosomy, unbalanced translocation or isochromosome 17 which involve the loss of one TP53 locus, they are described in sMDS/AML after treatment with chemotherapy and/or radiotherapy, usually its associate with other complex genetic abnormalities.

It has been proved that chromosome 17p deletion with consistent involvement of TP53 gene located at 17p13 is associated with vacuolated pseudo-Pelger-Huet granulocytes. Those patients have poor prognosis both in MDS and AML.
