**3. Conclusion**

Cytokeratins are essential protectors of epithelial structure found in the intracytoplasmic cytoskeleton of epithelial tissue. The occurrence of mutation in cytokeratin genes generates several genetic dermal disorders. In this genetic alteration, several environmental factors (ultraviolet, reactive oxygen species (ROS), deaminating agents, polycyclic aromatic hydrocarbon (PAH), ethylnitrosourea, azide, dyes, and heavy metals) take place as mutagen factors. The present chapter conclusively stated different cytokeratins disorders caused by environmental mutagens, i.e., synthetic or natural mutagens. In the end, based on environmental mutagens contributions, it can be stated that the genetic and epigenetic effects, arise/enhance through environmental mutagens/carcinogens, are the subject of innovative research.

**145**

**Author details**

Vishnu Sharma1

and Manish Biyani1,2

and Technology, Japan

\*, Tarun Kr. Kumawat1

\*Address all correspondence to: vishnusharma666@yahoo.com

provided the original work is properly cited.

, Garima Sharma1

1 Department of Biotechnology, Biyani Girls College, Jaipur, Rajasthan, India

2 Department of Bioscience and Biotechnology, Japan Advanced Institute of Science

© 2021 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/ by/3.0), which permits unrestricted use, distribution, and reproduction in any medium,

, Rashi Garg1

*Contribution of Environmental Constituents in the Genomic Disruption of Cytokeratins*

*DOI: http://dx.doi.org/10.5772/intechopen.96877*

*Contribution of Environmental Constituents in the Genomic Disruption of Cytokeratins DOI: http://dx.doi.org/10.5772/intechopen.96877*
