**5. Conclusion**

Acute lymphoblastic leukaemia (ALL) is the commonest childhood cancer. However, conventional cytogenetic and molecular analyses fail to identify clonal driver alterations in approximately 25% of ALL in children and the majority of cases in adults but when they are present, they have a crucial role in the management of ALL patients. Recent advancements in gene expression profiling and genome-wide sequencing have revolutionized our understanding of ALL pathogenesis over the last years. As defined in this review, the accumulation of results has restructured ALL genetic classifications. Overall, we expect that research over the next decade can thoroughly define the genomic of ALL across all generations and refine the therapeutic algorithm to be more targeted and individualized.

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**Author details**

Mounia Bendari1

\*, Sofia Sraidi2

provided the original work is properly cited.

and Nisrine Khoubila<sup>2</sup>

2 Faculty of Medicine and Pharmacy of Casablanca, Hassan II University, Morocco

© 2021 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/ by/3.0), which permits unrestricted use, distribution, and reproduction in any medium,

1 Mohammed VI University of Health Sciences, Casablanca, Morocco

\*Address all correspondence to: bendarimounia@gmail.com

*Genetic Abnormalities in ALL*

*DOI: http://dx.doi.org/10.5772/intechopen.97429*

*Genetic Abnormalities in ALL DOI: http://dx.doi.org/10.5772/intechopen.97429*
