**7. Final considerations**

Fatal yellowing disease represents a threat of great magnitude to the Brazilian oil palm industry. For decades, several studies attempted to identify its causal agent without success. As a result, no measures used today can effectively reduce the economic loss for the oil palm industry due to this disease. The only glimpse of hope in solving this problem still resides in the genetic resistance found in the American oil palm. However, the road to transfer this resistance through interspecific crosses and backcrosses is very long and has many uncertainties.

The search for the primary stress leading to FY must go on, whether it is of biotic or abiotic origin - or the combination of both. Only then might be able to block its occurrence, or, if not possible to do that, develop early diagnostic tools to reduce its spread to a minimum.

Recent studies using single omics analysis have shown that these new technics can take the etiological studies regarding FY in oil palm to another level. We postulate that transcriptomics should be the next step in using omics to gain further insights regarding this disease. Even more, we believe that it should be done under the scope of a multi-omics integration (MOI) strategy, together with metabolomics, proteomics, and ionomics, at least.
