**6. Conclusion**

Obesity is a worldwide occurring problem that causes many medical disorders and diseases. Obesity is known to disrupt male fertility and the capacity to impair reproduction through alteration in the hypothalamic- pituitary-gonadal axis. The obesity induced disruption of testicular steroidogenesis and metabolic dysregulation, cytokines and adipokines negatively impact on semen parameters such as sperm concentration, motility, viability, and normal morphology. In addition, obesity inhibits chromatin condensation, DNA fragmentation, increases apoptosis and epigenetic changes that can be transferred to the offspring. A balanced diet and healthy lifestyle combined with regular physical activity can help to avoid metabolic syndrome and obesity and thus, may prevent obesity-induced male infertility. Spermatozoa are extremely sensitive towards oxidative stress. Therefore, a sensible daily supplementation of normal diet with an antioxidant-rich natural product such as RPO might be useful to protect spermatozoa from oxidative stress and helps to preserve male fertility.
