**9. Cecal slurry-induced peritonitis**

Given the short comings and technical difficulties associated with existing models of sepsis, Gonnert *et. al* [70], developed a new model of sepsis by transferring human fecal matter into rats. This model, termed cecal slurry-induced sepsis

(CS) has since been adapted in both mice and rats, wherein the contents from the cecum of unmanipulated animals are suspended in liquid form and injected into the abdominal cavity of other animals to induce polymicrobial sepsis [71–73]. The CS model of sepsis was initially limited to those who study sepsis in neonatal mice [74], but now is also utilized to study the pathogenesis of sepsis in adult and old mice [75].
