**10. Research envisaged using focal thrombotic stroke**

Marc De Ryck et al., studies Effect of Flunarizine on Sensorimotor deficits after neocortical infarcts in Rats. After the successful induction of infarcts, rats showed deficits in the proprioceptive placing of hind limbs. Treatment with flunarizine after infarction restored sensorimotor functions in rats [71].

Jens Minnerup et al.studied the effect of intracarotid administration of human bone marrow cells in rats using a photothrombotic ischemia stroke model. Researchers confirmed no significant changes in neurological deficits with human bone marrow cells' treatment after 3 days of stroke induction. This failed neurological activity may be due to a delay in the initiation of treatment as human bone marrow cells have shown significant activity in other stroke models [72].

M De Ryck et al., have studied the lubeluzole's effect on sensorimotor function and infarct size using a photothrombotic stroke model in rats. After successful induction of stroke, it was found that functional deficits like tactile and proprioceptive hindlimb placing and infarcts were observed in the region parietal neocortex region of the brain. Treatment with lubeluzole after 5 min of post-infarct significantly restored all the functional deficits induced by photothrombotic stroke, but the effect seems to be declining with delaying in the initiation of treatment [73].

Boru hou et al.studied the effect of exogenous Neural Stem Cells (NSC) transplantation in Photothrombotic ischemia stroke in mice. After the successful induction of stroke, animals treated with NSC restored all brain functions; this was evident with their performance. Histopathological studies also confirmed that treatment with NSC showed a decline in brain cell damage caused by an ischemic stroke. Immunofluorescent assay for biomarkers revealed NSC's role as they differentiated into neurons and astrocytes to restore brain function [74].
