**3. Experimentally induced models of glaucoma**

To aid in the study of glaucoma-associated optic nerve damage, models have been created by directly damaging RGC axons or indirectly through elevation of IOP. The optic nerve can be crushed with self-closing fine forceps to cause temporally synchronous injury to the RGC axons. This experimental model is useful to study the effects of RGC damage, but does not replicate the spontaneous, continuous development seen in acute or chronic glaucoma. Kimura *et al*. advocate for experimentally inducible models due to the fact that wild-type animals can be used and the experimental condition can be meticulously monitored, as well as the progression of disease [46].
