**2. Requirements for preclinical models of Brucellar spondylodiscitis**

Investigators have previously established Brucellosis models in many diverse animals [15], however the animal candidates for stimulating *in vivo* Brucellar spondylodiscitis should be suitable for both the implantation of the *Brucella* bacteria and the convenience for the anatomical morphology research (**Table 1**). Common requirements for preclinical models of Brucellar spondylodiscitis are diverse, including but not limited to:


*Preclinical Models of Brucellar Spondylodiscitis DOI: http://dx.doi.org/10.5772/intechopen.98754*


#### **Table 1.**

*Comparison of the spine structure of animal models of brucellosis.*

