**Abstract**

Restitution of blood flow in the ischemic region helps liberate cells from mortification in any tissue or organ. Reperfusion post cerebral ischemia worsen the condition and lead to "cerebral reperfusion injury". In cerebral reperfusion injury, significant changes observed are infarct size, behavioural deficits, hematoma formation, inflammatory mediators, and oxidative stress markers representing the extent of brain injury. Experimental *In vivo* models mimicking pathological and neurological processes are key tools in researching cerebral reperfusion injury and potential therapeutic agents' development. This review explains currently used *In vivo* models like middle cerebral artery occlusion model, emboli stroke model, two-vessel occlusion model of forebrain ischemia, four-vessel occlusion model of forebrain ischemia, photochemical stroke model, collagenase induced brain haemorrhage model, autologous whole blood induced haemorrhage model. This review provides contemplative facts to setup authentic and relevant animal models to study cerebral reperfusion injury.

**Keywords:** Ischemia, Reperfusion injury, In vivo models, Stroke
