**4. Conclusions**

The pathogenesis of LVNC, a recently classified cardiomyopathy, remains largely unclear. With over 40 genes linked to LVNC, both genotype variation and phenotype variation are vast. Genetic testing in families and individuals with LVNC shas proved useful in identifying disease-causing variants. While the Notch signaling pathway is implicated in the pathogenesis of LVNC, there may be other pathways leading to congenital and acquired forms of LVNC. Identifying specific pathway elements is crucial for diagnosis and treatment. Modeling LVNC variants can help us to determine the genetic basis and pathogenesis of the disease.
