**6. Conclusion**

Glycation stress is a potential factor that reduces physical functions, which has become attention in recent years as well as oxidative stress. Glycation stress is mainly caused by intracellular AGEs formation and accumulation in the body, and also by ingestion from food products. Exposure to AGEs on skeletal muscle cells leads to skeletal muscle dysfunctions including reductions of mass, contractile function, insulin sensitivity. These dysfunctions seem to be attributed to RAGEinduced inflammatory responses and deteriorations of cellular signaling transduction, including insulin/IGF-1 signaling. However, some therapeutic strategies, such as treatment with RAGE antagonists, AGEs inhibitors, phytochemicals can overcome the aggravating effects. Glycation research on skeletal muscle has not been sufficiently carried out, and further studies in the future, especially the elucidation of the effect of glycation stress on skeletal muscle and its underlying molecular mechanism, and the development of strategies on preventing the accumulation of AGEs in skeletal muscle, are desired.
