**14.5 GSK-070**

It targets leucyl-tRNA synthetase and is an oxaborole derivative. Oxaborols block leucyl-t-RNA synthesis and ultimately results in blocking protein synthesis by constructing an adduct with t-RNA. It is active against both acute and chronic tuberculosis infection [10, 63].

### **14.6 PBTZ-169 & BTZ-043**

They belong to benzothiazinones and were diagnosed from a broth dilution evaluation in vitro for the detection of antibacterial and antifungal activities. Benzothiazinones basically prevents the formation of arabinose involved in the biosynthesis of cell wall by covalently targeting DprE1. Both PBTZ-169 and BTZ-043 are bactericidal thus prevents bacterial replication and multidrug-resistant tuberculosis infection. They represent almost equal potency against isoniazid and rifampin in the mouse models of recurrent tuberculosis infection. PBTZ-169 is under phase 1 scientific studies [7, 9, 63].
