**Author details**

12- to 14-day exposure. This compound is especially effective in killing MDR-TB strains that are resistant to currently used multiple drugs. The greater effect of FAS20013 compared to current anti-TB drugs in terms of its ability to sterilize TB injuries and kill latent TB strains. The FAS20013 has its efficiency in mice with no serious adverse effects and it is up to 100% bioavailable when orally used. The

Diamine SQ-109 was developed as a second-generation drug from the first-line drug ethambutol (EMB). When examined in a low-dose infection model of TB in mice, SQ-109 at 1 mg/kg was as efficient as EMB at 100 mg/kg. However, SQ-109 did not prove improved efficacy at higher doses (10 mg/kg; 25 mg/kg) and was less efficient than INH [121]. The SQ-109 is effictive against MDR-TB, together with

Tuberculosis (TB) is a chronic infectious disease caused by *M. tuberculosis*. Anti-TB drugs developed since the 1940s and their discovery resistance also developed against them. Acquired and primary drug resistances are the common pathways for the development of anti-TB drug resistance. Anti-TB drugs mainly act on protein synthesis, folic acid synthesis, mycolic acid synthesis, DNA synthesis, and ATP synthase. These anti-drugs cause bacteriostatic and/or bactericidal effects on the mycobacterium. The major resistance mechanism is the mutation of the target gene responsible for the action of anti-TB drugs. Anti-TB drug resistance produces a destructive effect on public health. Therefore, the advance study should be

conducted in the areas of finding new targets for the development of novel anti-TB

The *Mtb* is relatively vulnerable to Nitro-containing compounds [122]. Nitrofuranylamide (**16**) was accepted in testing for UDP-Gal mutase inhibition. A prolonged set of nitrofuranylamides was tested for anti-microbial activity. This led to the recognition of several nitrofuranylamides with activity effective

compound is acted by inhibition of ATP synthase [120].

*Molecular Epidemiology Study of Mycobacterium Tuberculosis Complex*

**Diamine SQ-109**

those that are EMB-resistant. **Nitrofuranylamides**

against *Mtb* [123].

**6. Conclusion**

drugs.

**46**

Saad Alghamdi<sup>1</sup> and Mohammad Asif2 \*

1 Laboratory Medicine Department, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia

2 Department of Pharmaceutical Chemistry, Himalayan Institute of Pharmacy Research, Dehradun, Uttarakhand, India

\*Address all correspondence to: aasif321@gmail.com

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