**5. Conclusion remark**

In conclusion, the main hallmark of cancer is the intrinsic or requisite resistance to apoptosis, and the evasion of apoptotic cell death can be part of cellular response to stressful stimuli. Based on our understanding of how the dysregulation of the apoptosis pathway leads to cancer, approaches to target anti-apoptosis Bcl-2 family proteins have proven to be effective in the treatment of cancers, especially lymphatic cancers. However, cancer cells often outsmart these therapeutic interventions by modulating the expression of other molecules of apoptosis. Novel combination approaches are warranted to overcome this drug-induced resistance. More importantly, the new perspective and pieces of evidence are needed for powerful approaches to overcome drug resistance in cancer cells in clinical use. Therefore, the current knowledge needs a further understanding of how different cellular stresses trigger anti-apoptotic mechanisms, and how these effects lead to apoptotic resistance in cancer cells.
