**7. Conclusions**

Meningiomas may sometimes recur as multicentric-diffuse forms, with dural infiltration and recurrent tumor mass distal to the initial site. These may result from the progressive growth of multiple tumor nodules with different growth potential.

Flat-shaped radiological aspect and Ki67 Li ≥4% at initial diagnosis are related to higher risk of recurrence in multicentric-diffuse pattern.

Patients with not anaplastic intracranial meningioma with prevalent intradural component and not extensive dural infiltration may undergone multiple surgical operations during years experimenting good postoperative quality of life.

Further studies will investigate whether the different patterns of regrowth and recurrence correspond to different biomolecular and genetic expression of the meningioma. This will aid to predict the tumor behavior and to detect the most appropriate molecular therapies.
