**Abstract**

This chapter aims to demonstrate why a precautionary and bioethical approach is needed to avert forthcoming pandemics due to zoonosis. Precautionary principle should be intended as a conceptual tool for assessing whether human action, and its arising environmental alterations, exceed the absorption capacity of Nature. Likewise, original meaning of *bioethics*, namely the questioning of unsustainable progress and human survival, should be resumed to reflect on human footprint on biodiversity. This reflection seems to be even more pressing if we consider how national policies are struggling to face the pandemic's socio-economic consequences. Focusing on how to prevent zoonosis' events, by pondering on the concept of 'biological wisdom' coined by Van Rensselaer Potter, might be more effective than suggesting complex reforms of healthcare systems. Furthermore, a bioethical approach, by its very definition, consists of a multidisciplinary approach, increasingly worthwhile in present-day societies characterized by strong complexity. Indeed, the SARS-CoV-2 pandemic has demonstrated how dense is the network of nature, human beings and socio-economic structures. It seems appropriate to think origins of SARS-CoV-2 pandemic as a warning for the future, by questioning methods and extension of human impact on biodiversity.

**Keywords:** SARS-CoV-2 Origin, COVID-19, Bioethics, Wildlife Preservation, Precautionary Principle, Anthropocene, Public Health
