**Abstract**

SARS-CoV-2 pandemic issue threatening world health and economy became a major problem with its destructive impact. The researchers have seen that conventional methods related to medicine and immunological background do not resolve this disease by gained knowledge of viruses previously studied. Advances in computational biology comprising bioinformatics, simulation, and yielded databases have accelerated and strengthened our facilities to predict some cases related to the biological complex by comparison with the use of artificial intelligence. Various novel drugs by using *in silico* resources and *in vivo* imaging techniques associated with high-resolution technologies can cause the confidential development of methods for the detection of antiviral drugs and the production of diagnosis kits. In the future, we will start seeing these novel techniques' positive reflection and their advantages in cost/time effective profits. This chapter highlights these approaches and addresses updated knowledge currently used for research and development.

**Keywords:** Computational biology, Drug discovery, Genomics, Omics science, SARS-CoV-2
