**4. Conclusions**

Gold catalyzed asymmetric transformations is an emerging area. Enantioinduction with gold(I) catalysts, is a challenging task due to its preferred linear coordination mode, that place the substrate far from the chiral ancillary ligands. Nonetheless, to date several successful strategies have arose. Some are based on using sterically congested ligands, that create a chiral pocked around the active site, others use bifunctional phosphines, that stablish secondary interactions with the substrate, and finally others are based on using tight ion pairing with chiral anions. On the other hand, asymmetric catalysis with gold(III) is just beginning to be developed. When introducing ancillary ligands around gold(III), a fair balance between stability and activity must be reached. By far, cyclometalated complexes of gold(III) have shown that it is possible to undergo catalytic asymmetric reactions with gold(III), manifesting its great potential. A deeper development is expected in near future with gold(III)**.**

#### **Acknowledgements**

This work was supported by CONACyT (A1-S-7805) and DGAPA (IN202017).

## **Conflict of interest**

The authors declare no conflict of interest.

## **Appendices and nomenclature**


**33**

**Author details**

Susana Porcel García

Ciudad de México, México

Institute of Chemistry, Universidad Nacional Autónoma de México,

© 2021 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/ by/3.0), which permits unrestricted use, distribution, and reproduction in any medium,

\*Address all correspondence to: sporcel@unam.mx

provided the original work is properly cited.

*Gold Catalyzed Asymmetric Transformations DOI: http://dx.doi.org/10.5772/intechopen.97519*

BINOL 1,1′-binaphthalene-2,2′-diol CSA camphor sulfonic acid

DTBM-SEGPHOS [(4*R*)-(4,4′-bi-1,3-bezodioxole)-5,5′-diyl]bis[bis(3,5-

DM-SEGPHOS 5,5'-bis[di(3,5-xylyl)phosphino]-4,4′-bi-1,3-benzodioxole BIPHEP bis(diphenylphosphino)-6,6′-dimethoxy-1,1′-biphenyl XantPhos 4,5-bis(diphenylphosphino)9,9-dimethylxanthene TADDOL α,α,α,α-tetraaryl-1,3-dioxo-lane-4,5-dimethanol

di-tert-butyl-4-methoxyphenyl)phosphine]

*Gold Catalyzed Asymmetric Transformations DOI: http://dx.doi.org/10.5772/intechopen.97519*

*Current Topics in Chirality - From Chemistry to Biology*

Au cat (5 mol%) AgBF4 (5 mol%) CHCl3, -40 °C R

+

*Asymmetric transformations with chiral NHC-biphenyl gold(III) complexes.*

Au cat. (10 mol%) L-CSA (2.5 mol%) toluene, r.t., 16 h <sup>R</sup><sup>1</sup>

H

H + R H

Up to 40% conversion Up to 88% *ee*

Au cat (10 mol%) AgNTf2 (5 mol%) 4 Å MS, 0 °C, 24 h PhCF3/MeNO2 (4:1)

R Cl <sup>1</sup> CO2R

N N Au

> N N N

O

Au

Au cat =

CO2R R2 O R1

Up to 87% yield Up to 98% *ee* d.r. up to 11.7:1

OR<sup>2</sup>

Au cat =

Up to 80% yield Up to 90% *ee*

Au cat =

O O Au N O Me

Me

Me

**32**

**4. Conclusions**

R (+/-)

1)

2)

**Figure 17.**

**Figure 18.**

O

R2

R1

OR<sup>2</sup> OR<sup>2</sup>

*Asymmetric carboalkoxylation of alkynes with gold(III) complexes.*

**Acknowledgements**

**Conflict of interest**

The authors declare no conflict of interest.

**Appendices and nomenclature**

Gold catalyzed asymmetric transformations is an emerging area. Enantioinduction

This work was supported by CONACyT (A1-S-7805) and DGAPA (IN202017).

Tol-BINAP 2,2'-bis(di-*p*-tolylphenylphosphino)-1,1′-binaphthyl *i*Pr-DuPHOS 1,2-bis[(2S,5S)-2,5-diisopropylphospholano]benzene

with gold(I) catalysts, is a challenging task due to its preferred linear coordination mode, that place the substrate far from the chiral ancillary ligands. Nonetheless, to date several successful strategies have arose. Some are based on using sterically congested ligands, that create a chiral pocked around the active site, others use bifunctional phosphines, that stablish secondary interactions with the substrate, and finally others are based on using tight ion pairing with chiral anions. On the other hand, asymmetric catalysis with gold(III) is just beginning to be developed. When introducing ancillary ligands around gold(III), a fair balance between stability and activity must be reached. By far, cyclometalated complexes of gold(III) have shown that it is possible to undergo catalytic asymmetric reactions with gold(III), manifesting its great potential. A deeper development is expected in near future with gold(III)**.**

