**Author details**

Erland Johansson\* and Anders B. Falk EJSelenkonsult AB., Uppsala, Sweden

\*Address all correspondence to: 101jejohansson@gmail.com

© 2021 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/ by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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*Erythrocytes as Biomarkers of Virus and Bacteria in View of Metal Ion Homeostasis*

analyses of human and murine terminal erythroid differentiation. Blood.

[11] Liang R, Campreciós G, Kou Y, McGrath K, Nowak R, Catherman S, et al. A systems approach identifies essential FOXO3 functions at key steps of terminal erythropoiesis. PLoS Genet.

[12] Wei J, Zhao J, Schrott V, Zhang Y, Gladwin M, Bullock G, et al. Red blood cells store and release Interleukin-33. J Investig Med. 2015;**63**(6):806-810.

[13] Klei TRL, Dalimot JJ, Beuger BM, Veldthuis M, Ichou FA, Verkuijlen PJJH,

erythrocyte senescence and leads to Lu/ BCAM and CD44 adhesion molecule

[14] Li K-Y, Zheng L, Wang Q, Hu Y-W. Characteristics of erythrocyte-derived microvesicles and its relation with atherosclerosis. Atherosclerosis.

[15] Prudent M, Delobel J, Hübner A, Benay C, Lion N, Tissot J-D. Proteomics of stored red blood cell membrane and storage-induced microvesicles reveals the Association of Flotillin-2 with band 3 complexes. Front Physiol. 2018;**9**:421.

[16] Mantel P-Y. Malaria-infected erythrocyte-derived microvesicles mediate cellular communication within the parasite population and with the host immune system. Cell Host &

[17] Hotz MJ, Qing D, Shashaty MGS, Zhang P, Faust H, Sondheimer N, et al. Red blood cells Homeostatically bind mitochondrial DNA through TLR9 to maintain quiescence and to prevent lung injury. Am J Respir Crit Care Med.

Microbe. 2013;**13**:521-534.

2018;**197**(4):470-480.

et al. The Gardos effect drives

activation. Blood Advances. 2020;**4**(24):6218-6229.

2016;**255**:140-144.

2014;**123**(22):3466-3477.

2015;**11**(10):e1005526.

*DOI: http://dx.doi.org/10.5772/intechopen.97850*

[1] McCullough J. RBCs as targets of infection. Hematology Am Soc Hematol Educ Program. 2014;**2014**(1):404-409.

[2] Minasyan H. Phagocytosis and oxycytosis: Two arms of human innate

immunity. Immunol Res. 2018;**66**(2):271-280.

2020;**16**(2):e1008258.

Immunol. 2015;**6**:279.

[3] Anderson HL, Brodsky IE, Mangalmurti NS. The evolving erythrocyte: Red blood cells as modulators of innate immunity. J Immunol. 2018;**201**(5):1343-1351.

[4] Popovici J, Roesch C, Rougeron V. The enigmatic mechanisms by which plasmodium vivax infects Duffynegative individuals. PLoS Pathog.

[5] Horuk R. The Duffy antigen receptor for chemokines DARC/ACKR1. Front

[6] Reich D, Nalls MA, Kao WHL, Akylbekova EL, Tandon A, Patterson N, et al. Reduced neutrophil count in people of African descent is due to a regulatory variant in the Duffy antigen receptor for chemokines gene. PLoS

Genet. 2009;**5**(1):e1000360.

[7] Naidoo KK, Ngubane A, Gaza P, Moodley A, Ndung'u T, Thobakgale CF. Neutrophil effector functions are not impaired in Duffy antigen receptor for chemokines (DARC)-null black south Africans. Front Immunol. 2019;**10**:551.

[8] Karsten E, Herbert BR. The emerging role of red blood cells in cytokine signalling and modulating immune cells. Blood Rev. 2020;**41**:100644.

[9] Karsten E, Breen E, Herbert BR. Red blood cells are dynamic reservoirs of cytokines. Sci Rep. 2018;**8**(1):3101.

[10] An X, Schulz VP, Li J, Wu K, Liu J, Xue F, et al. Global transcriptome

**References**

*Erythrocytes as Biomarkers of Virus and Bacteria in View of Metal Ion Homeostasis DOI: http://dx.doi.org/10.5772/intechopen.97850*
