**Acknowledgements**

I would like to thank my supervisors Professor Ann Simpson, Professor Kaneez Fatima Shad and Associate Professor Sara Lal for their constant support and guidance. Special thanks to Associate Professor Louis Cole and Dr. Christian Evenhuis for providing confocal microscopy and OMERO software facilities, to identify peripheral markers of HTN in HFAs, WKY and SHR. I would also like to thank Dr. Matt Padula for providing facilities to perform SP3 experiments and LC/MS/MS detection of HFA-proteins. I would like to acknowledge "Australian Government Research Training Program Scholarship".
