Meet the editors

Dr. Ana Gil de Bona received her Ph.D. in Molecular Biology and Microbiology from Complutense University of Madrid, Spain. Her research mainly focused on the study of the proteomic profile of the extracellular vesicles and the secretome in virulent and avirulent strains of Candida albicans. She continued her scientific career at the University of Massachusetts Medical School, USA, working in yeast genetics and proteomics. Her current

research at the Forsyth Institute, USA, is focused on understanding the changes in tooth enamel in healthy and defective teeth to find better diagnostics tools and treatment approaches. She has authored peer-reviewed research articles and reviews and has presented her work at national and international scientific meetings.

Dr. Hakan Karaaslan completed his endodontic training at Hacettepe University, Turkey, where he received his DDS. His post-graduate thesis work focused on the mineral content and structure of dentin exposed to bleaching agents. Pursuing his interest in understanding the development and structure of dental hard tissues, he worked at Dr. Tim Bromage's Lab at New York University on the incremental nature of enamel. At the Forsyth

Institute, USA, Dr. Karaaslan currently investigates developmental dental defects, in particular molar hypomineralization, furthering his passion for hard tissue biology. As an endodontist and a clinician, he also seeks to understand the pulpal aspect of enamel defects and translate basic science findings into clinical therapeutics.

Contents

**Section 1**

*In-Woong Um and Yu-Mi Kim*

Processes Relationship

and Clinical Features

*and Andreea Moldoveanu*

*by Sukumar Athimoolam*

*Luis Romeu and Antonio Liras*

**Section 2**

*by Francesco Grande and Santo Catapano*

*by Emilia Severin, George Gabriel Moldoveanu* 

**Preface XI**

Dental Defects **1**

**Chapter 1 3**

**Chapter 2 19**

**Chapter 3 39**

Genetic Components of Developmental Dental Defects **59**

**Chapter 4 61**

**Chapter 5 107**

**Chapter 6 131**

The Components of Dental Hard Tissues and Developmental

Fluoride and Other Trace Elements in Dental Hard Tissue *by Y.B. Aswini, Vikrant Mohanty and Kavita Rijhwani*

Developmental Dental Defects and Tooth Wear: Pathological

Failure of Tooth Development: Prevalence, Genetic Causes

Influence of Elements on Gene Expression in Human Teeth

*by Juan Andrés de Pablo, Luis Javier Serrano, Mariano García-Arranz,* 

Gene and Cell Therapy in Dental Tissue Regeneration

Organic Matrix of Enamel and Dentin and Developmental Defects *by Eui-Seok Lee, Puneet Wadhwa, Min-Keun Kim, Heng Bo Jiang,* 

## Contents


Preface

Covered by dental enamel, supported by dentin and cementum, and given life by the pulp in its core, the human tooth is indeed an extraordinary tissue. Despite this, teeth are often affected by dental caries or cavities. Research on dental hard tissues and their developmental pathologies is attracting more attention from the scientific community. This book presents the basics of developmental dental defects, which affect a large population worldwide and thus require new preventive and therapeu-

This book is organized into two sections. Section 1, "The Components of Dental Hard Tissues and Developmental Dental Defects," covers the basics of the human tooth while emphasizing the importance of organic content and trace elements. These components are responsible for giving the unique chemical and mechanical properties of dental hard tissues along with the hydroxyapatite-based mineral

Section 2, "Genetic Components of Developmental Dental Defects," elucidates the complex genetic machinery behind tooth development. It provides an introduction to the genetic and epigenetic basis of developmental dental defects and directs the

This book presents the basics of developmental dental defects in chapters written by experts from all over the world. We are confident that students, scientists, and clinicians from diverse backgrounds will find this book useful and we hope the information contained herein contributes to future research in the field.

**Ana Gil de Bona and Hakan Karaaslan**

Harvard School of Dental Medicine, Cambridge, Massachusetts, USA

The Forsyth Institute,

tical approaches.

reader to the relevant literature.

phase.
