**Acknowledgements**

The authors thank the São Paulo Research Foundation (FAPESP, 2018/25207-0, 2017/50085-3, 2018/23478-7, 2019/00063-9, 2019/00018-3), the Brazilian National Council of Scientific and Technological Development (CNPq, 401170/2016-0), the Coordination for the Improvement of Higher Education Personnel (CAPES, 88887.115406/2015) and INCTBio (FAPESP, 2014/50867-3) for financial support and fellowships.
