**Author details**

*Pheochromocytoma, Paraganglioma and Neuroblastoma*

usually treated surgically, but also in a multidisciplinary way with chemotherapy and radiotherapy. Each of these disciplines has led to many improvements in the survival of these patients but also to an increase in morbidity. Designing targeted therapies is a priority in order to achieve more effective treatment with less collateral damage. Azmi [23] in 2013 and Muller [24] in 2014 tested the therapeutic potential of Snail and c-Myc inhibitory molecules, respectively. Also Chua [25] in 2012 carried out a study aimed at identifying inhibitors of epithelial – mesenchymal transition in order to inhibit cell invasiveness and metastasis. The future direction should point to a complete identification of these factors which are very important for both neural crest development and tumor growth and metastasis, including cell survival, proliferation, motility, invasiveness, and differentiation. Only a more complete understanding of molecular similarities, we will then be poised to develop targeted therapies aimed at modulating those processes that are critical to tumor growth and metastasis. Testing potential new anti-cancer drugs is also an important future step, but is often slow, expensive, and limited to cultured cancer cells or artificial tumor models. NC development study can certainly represent a fundamental topic through which to develop new strategies and new drugs for cancer therapy. In this book we want to offer the reader some elements of epidemiology, genetics and treatment of pheochromocytoma, paraganglioma and neuroblastoma. Our work does not reach definitive conclusions but aims to provide elements of knowledge regarding non-common neoplasms that have a unique denominator: they are

*Cancer metastasis and neural crest cell migration exhibit striking similarities [22].*

**6**

**Figure 2.**

Neural crest cell-derived tumors.

Pasquale Cianci1 \*, Giandomenico Sinisi2 and Sabino Capuzzolo2

1 Department of Surgery and Traumatology, Lorenzo Bonomo Hospital, ASL BAT, University of Foggia, Andria, Italy

2 Department of Surgery and Traumatology, Dimiccoli Hospital, ASL BAT, Barletta, Italy

\*Address all correspondence to: ciancidoc1@virgilio.it

© 2021 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/ by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
