Meet the editors

Pasquale Cianci, MD, Ph.D., AACS, is a general surgeon at "Lorenzo Bonomo" Hospital-Andria, Italy. He obtained a Ph.D. from the Department of Medical and Surgical Sciences, University of Foggia, Italy. He is an associate member of the American College of Surgeons (ACS) and a contract professor of Emergency Surgery, and Human Physiology, University of Foggia - Nursing Science and Physiotherapy Courses. He is also a Professor of

Surgical Anatomy. Dr. Cianci is a member of The European Association for Endoscopic Surgery (EAES), Italian Society of Endoscopic and Minimally Invasive Surgery (SICE), Association of Italian Hospital Surgeons (ACOI), Polispecialistic Society of Young Surgeons (SPIGC), Società Italiana Unitaria Colonproctologia (SIUCP), and Associate of American College of Surgeons AACS. He has authored sixty national and international scientific papers. He is an editorial board member and reviewer for numerous journals. He has spoken at many surgical congresses. His special interests include laparoscopic surgery, robotic surgery, endocrine surgery, and coloproctology.

Enrico Restini, MD, is head of the Department of Surgery and Traumatology-Andria, Italy. He is a contract professor in Surgery and Health Management and an expert in advanced technologies and their impact on health organizations (HTA) (LUM University-BA). Since 2007, Dr. Restini has been honorary president of the Apulian section of Aistom. He is a member of the Society of American Gastrointestinal and Endoscopic Surgeons (SAGES),

the Italian Society of Endoscopic and Minimally Invasive Surgery (SICE), SICOB, SIC, Italian Society of Private Hospital Surgery, and Association of Italian Hospital Surgeons (ACOI). He is a founding member of ARTOI, and has been a SICE National Councilor since 2012. He has spoken at numerous national and international surgical congresses and authored fifty national and international scientific papers. His special interests include laparoscopic surgery, robotic surgery, endocrine surgery, and digestive surgery.

Amit Agrawal MCh completed his neurosurgery training at the National Institute of Mental Health and Neurosciences, Bangalore, India, in 2003. Dr. Agrawal is a self-motivated, enthusiastic, and results-oriented professional with more than seventeen years of rich experience in research and development as well as teaching and mentoring in the field of neurosurgery. He is proficient in managing and leading teams for running successful process

operations and has experience in developing procedures and service standards of excellence. He has attended and participated in many international and national symposiums and conferences and delivered lectures on vivid topics. He has published more than 750 articles in the medical field covering various topics in various national and international journals. His expertise is in identifying training needs, designing training modules, and executing the same while working with limited resources. He has excellent communication, presentation, and interpersonal skills with proven abilities in teaching and training for various academic and professional courses. Presently, he is working at the All India Institute of Medical Sciences, Bhopal, Madhya Pradesh.

Contents

**Section 1**

**Section 2**

**Section 3**

*and Paola Defilippi*

**Preface XI**

Introduction **1**

**Chapter 1 3**

Pheochromocytoma and Paraganglioma **11**

**Chapter 2 13** Pheochromocytomas and Paragangliomas: Genotype-Phenotype Correlations

**Chapter 3 25**

**Chapter 4 47**

Neuroblastoma **61**

**Chapter 5 63**

**Chapter 6 75**

Primary Central Nervous System Neuroblastoma: An Enigmatic Entity

The Scaffold Protein p140Cap as a Molecular Hub for Limiting Cancer

*by Giorgia Centonze, Jennifer Chapelle, Costanza Angelini, Dora Natalini, Davide Cangelosi, Vincenzo Salemme, Alessandro Morellato, Emilia Turco* 

Metastatic Paragangliomas and Pheochromocytomas: An Epigenetic View

*by María-Dolores Chiara, Lucía Celada, Andrés San José Martinez,* 

*Tamara Cubiella, Enol Álvarez-González and Nuria Valdés*

Introductory Chapter: Neural Crest Cell-Derived Tumors. An Introduction

on Pheocromocytoma, Paraganglyoma and Neuroblastoma *by Pasquale Cianci, Giandomenico Sinisi and Sabino Capuzzolo*

*by Diana Loreta Paun and Alexandra Mirica*

Surgical Approach in Pheochromocytoma *by Radu Mihail Mirica and Sorin Paun*

*by Rakesh Mishra and Amit Agrawal*

Progression: A New Paradigm in Neuroblastoma
