**2.2 Target proteins collection**

All the seven proteins of Ebola virus were chosen as targets. The structures of GP (PDBID: 5JQB), VP35 (PDBID: 3FKE), VP24 (PDBID: 4M0Q ), VP30 (PDBID: 5DVW), VP40 (PDBID: 4LDB) and NP (PDBID: 4Z9P) proteins of EBOV were collected from Protein Data Bank which is an open access online database for the 3D structural data of biological macromolecules [31]. The retrieved structure of GP protein had one mutation at position no 42. The mutation was returned to the reference state through the utility of Spdbv software (Alanine nucleotide was converted to Threonine nucleotide). There was no structure of EBOV L protein in the PBD. The sequence of L protein was taken from UniPort and modeling was performed by Swiss-model [32–34]. All water molecules and hetero-molecules that attached to the protein structures were eliminated. The drawn structures of Ebola proteins are shown below in **Figure 1**.
