**3.5 Antibacterial drugs**

For wound health, filtration, and active packaging systems antimicrobial nanofibers incorporated with antibacterial drugs have become one of the promising nano-scale materials. A vast range of antibacterial drugs such as peptides and antibiotics have been formulated physically or chemically within electro spun

nanofibers or on their surfaces. The polymer degradation, release profile, and release pathway of antibacterial drugs from electro spun nanofibers has a linkage with the release mechanism of antibacterial drugs which may be regulated through the composition of polymer and fibre morphology [26].

Antibacterial drugs encapsulated in electro spun nanofibers have been proved to sustain the antibacterial property over a longer time compared to the un-encapsulated form. A sodium alginate electro spun nanofibers loaded with ciprofloxacin was developed by a team and it was tested for its antimicrobial activity against *Staphylococcus aureus*. The minimum inhibitory concentration [MIC] of ciprofloxacin required is found to be 0.125 μg/mL through this study [27]. Similarly, another team worked on developing nisin nanofibers/cellulose acetate which resulted in approx. 99.9% reduction of *S. aureus* [28].
