**6. Conclusion**

Limited stability of nanosilver without stabilizing envelopes in biologically relevant media, cytotoxicity for both eukaryotic and bacterial cells, negligible cellular uptake restrict their further implementation for combined antiviral and antibacterial therapy. However, spontaneous binding with the major blood proteins and anti-inflammatory properties with inhibition of cytokine production at the early stages after treatment may be helpful in prevention of cytokine storm caused by RNA-containing viruses.

#### **Conflict of interest**

The authors declare no conflict of interest.

## **Author details**

Olga V. Morozova1,2\* and Dmitry V. Klinov1,3

1 Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Russia

2 Ivanovsky Institute of Virology of the National Research Center of Epidemiology and Microbiology of N.F. Gamaleya of the Russian Ministry of Health, Russia

3 Moscow Institute of Physics and Technology, Russia

\*Address all correspondence to: omorozova2010@gmail.com

© 2021 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/ by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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