**Author details**

*Silver Micro-Nanoparticles - Properties, Synthesis, Characterization, and Applications*

**Method of preparation of nanoparticles**

Chemical method (NaBH4)

(sodium citrate)

(sericin and chitosan)

Irradiation method (UV radiation)

method (UV radiation, gamma rays 60Co)

(reduction at 40°C

(reduction at 70–100°C

**Size (nm) Result**

2–3 Significant antibacterial activity

4–8 It showed inhibitory effects on

— Used as a burn wound dressing

90 Antimicrobial activity against

5–14 Antimicrobial activity against

7–21 Removes the exudates and

240–970 Bactericidal action [111]

against *Escherichia coli* [109]

the bacteria growth [110]

due to its good antibacterial activity [112]

*Escherichia coli, Staphylococcus aureus and Candida albicans* [113]

*Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa* [114]

prevents wound maceration [115]

explored for wound healing activity. Beside this they are far away from clinical practice as well as commercialization. More rigorous preclinical investigations are still required to validate their capability for tissue regeneration. Apart from that work is also needed to be done on industrial scale up techniques for commercialization.

Nanomaterial's now a days representing potential ways for combating microbial

related diseases and disorders. Wounds especially chronic ones burdened with resistant microbes are posing serious challenge to healthcare system. For that purpose silver nanoparticles impregnated wound dressing due to their excellent antimicrobial potential are not less than a boon. Along with sterilization they are proven to fasten tissue repair in wounds. Presently more rigorous efforts are needed in their preclinical investigations to evaluate their efficacy verses safety ratio. They

The authors are also thankful to Guru Nanak Dev University, Amritsar for

have capability to become potential wound dressing of future.

providing various facilities to carry out the work.

The authors declare no conflict of interest.

**136**

**10. Conclusion**

**Table 4.**

**Polymer used for preparation of hydrogels**

vinyl alcohol

2-acrylamide-2 methylpropane sulphonic acid sodium salt

Poly acrylic acid and poly

Beta- chitin Chemical method

Chitosan Green method

Poly vinyl alcohol Irradiation

Collagen Thermal method

Carboxymethylcellulose Thermal method

*Silver nanoparticles incorporated hydrogels for wound management.*

**Acknowledgements**

**Conflict of interest**

Atamjit Singh\*, Kirandeep Kaur, Komalpreet Kaur, Jaijeet Singh, Nitish Kumar, Neena Bedi and Preet Mohinder Singh Bedi Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab, India

\*Address all correspondence to: atamjitpharma.rsh@gndu.ac.in

© 2021 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/ by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
