b.Patient related risk factors for bleeding:

Current active major bleeding with need for transfusion Current chronic bleeding over 48 hours Bleeding disorders (e.g. hemophilia) Recent central nervous system bleeding Intracranial or spinal lesion Current renal impairment with secondary coagulation did Underlying coagulopathy or coagulation factor abnormalities Thrombocytopaenia.- a platelet count <50000/uL Severe platelet dysfunction Active peptic ulcer or active ulcerative gastrointestinal disease Obstructive jaundice or cholestasis Recent major surgical procedure with a high bleeding risk [2, 3].
