*A.1.3 Scene environments*

Testing environments for adult-onset dementia-related patients should not be designed to evaluate decisions based on visible timer scoring, navigation decisions through civil-type architecture or semantic response requirements. These do not represent measure states of neuroinflammation-affected decision-making, based on short-term learning and recall.

Sky and ground assets above the horizon should be reported in the assetinventory as either left and right orientable.

Parameters that describe the maximum spread of the wavelength field such as fulcrum depth and width can also be used to evaluate conscious-state transition where there are compounding or ageing related deficits in one or both hemispheres. These parameters describe the geometric projection of the user's virtual camera-space and orientation of the player's head rotation and line of direction in the virtual scene. and vegetation-variation, vegetation-windspeed events and so on. Keep in mind that virtual reality involving scores and changing scenes can trigger psychological discomfort, dizziness, eye-strain and even addiction [79–81]. For this reason, there should be only one scene with nature-related motion such as wind in grass or tree

*The Need for XR-Measurement of Decision-Making Decline and Conscious-State Transition…*

Audio settings are vital to immersive realism but, may be varied on left and right, such as for early dementia-related auditory-thalamocortical peri-operative risk evaluation or for patient prescription purposes. Manufacturer settings usually

No civil society structures, roads, signs whether semantic or drawings, volumemeasurement, clock-measurement or human relationship and non-nature type cue references should be included in neurobehavioral XR-testing that is intended to predict the condition of neuronal-nucleic cellular health or tissue functioning.

Thirty second sampling intervals to collect the sensorimotor response and heartrate variation represents successive periods for potential long-term synaptic potentiation in the patient, such as would belong to a learning or decision event based and with matching cerebroarterial blood flow occurring in potential simultaneous XR-fMRI BOLD patient observation. Since daylight variations is composed of wavelengths of light whose frequency and phase change with the position of the sun, it is important to sample for all significant periods of the day in which daylight variation is significant, i.e. the behavioral response from pre-dawn all the way to post-dusk in 3 minute intervals for minimum of 5 or 6 XR-testing sessions, as shown in the sampling tables, below. During an XR-session, wavelight phase information stimulates the retinal cells depending on the device illumination levels (sometimes referred to as *Troland* units, representing retinal illumination from 1mm<sup>2</sup> pupil area

vibromechanically by the photosensitive retinal ganglion cells onto the

targets in the retinohypothalamic and limbic region circuitry [83].

if the thunder does not occur. In this process, nonconscious autonomic

suprachiasmatic nuclei cells which directly stimulate the hippocampal neural bed for short-term neuronal growth. The process relies on intracellular transport via light-sensitive heterodimerization which recruits specific proteins in hippocampal neurons, involving recycling endosomes on behalf of neuron axon outgrowth [82]. If XR is used as a circadian prosthetic, this information can be helpful to measuring the amount or volume of full daylight needed for restoring circadian synchronization, using known optogenetic principles of cellular mitochondrial activation and

During a single test event an unconditional stimuli (US) is followed by an unknown conditional stimulus (CS) to the patient, as described in the chapter. This can be for example, a sudden thunder event in a random location that follows the appearance of a bird. The response to the stimuli should be reasonable but significant enough to trigger a cognitive autonomic learning process in healthy controls so that the response behavior is repeated at the next appearance of the same bird, even

decisionmaking behaviour can be recorded by any XR-scripts that report the raycast change of direction associated with the patient's change of focus and change of heartrate. In Alzheimer's Disease related dementia, for example, there would a

) of scene light). Light information is translated

branch swaying, and water ripples rather than ground buoyancy.

offer sufficient audio control parameters.

*DOI: http://dx.doi.org/10.5772/intechopen.97384*

*A.1.7 3D-Audio*

*A.1.8 Scene bias*

*A.1.9 Behavioral sampling*

exposed to 1cd/m<sup>2</sup> (candelas/m<sup>2</sup>

**277**

The raycast direction is the parameter used in scripts of assets to report the player's line of direction. The raycast direction describes direction of focus , and is key to describing a change in patient conscious-state. The rate of change of raycast direction is used in behavioral response measurements in recognition and recall of an asset during a nonconscious test.

#### *A.1.4 Light wavelength calibration*

Wavelength intensity can be given for assets in parameters from all assets, including sky and ground, vegetation, weather and wildlife. The parameters can be described as0-1 transparency alpha, depth projection, non-spectral shading component size, reflective source component size, rate of single-asset motion (blur), landscape contrast intensity (sharpness), and scene illumination intensity, whichever is appropriate and convenient to describing striking behavioral response differences.

The most critical wavelengths are blue:450–485 nm 620–680 THz 2.64–2.75 eV and red: 625–740 nm 405–480 THz 1.65–2.00 eV on behalf of impact to hippocampal neuronal, and genetic signaling targets involved in transcription/translation feedback loop of CLOCK and BMAL1, and the nucleus basalis magnocellularis projections to the suprachiasmatic nucleus (SCN) mentioned in the main chapter text and shown in **Figure 3**. Cone and melanopsin signaling determines brightness perception. There are references available which suggest that melanopsin excitation takes place at brightness equal to 1 cd <sup>m</sup><sup>2</sup> for an equal-energy-spectrum light at 1 cd <sup>m</sup><sup>2</sup> . The maximum range should lie within 380- 780 nm, which represents the range of skylight visible to human bioperception from pre-dawn to post-dusk.

#### *A.1.5 Retinal luminance*

Luminance is in the research to have a defined photon catch of around 480 nm of opsin.

For this reason, maximum error in the device rendering of luminance should be no more than 10% from this value based on maintaining exactly 480 nm spectrally per session.

Mobile device platform manufacturers have responded to health-risk concerns in reported from excess levels of LED blue-light exposure [76]. On the other hand, the research suggests improvements to these same conditions [77, 78]. For these reasons, timing and duration of a virtual reality monitoring session should be coordinated to start at the first eye-blink, and no longer than three (3) minutes. In fact, the first sampling of sensori-motor response and heart rate should be at the instance of the first patient saccadic (blink). This ensures coordination of the data collection with the timing of innate cognitive recognition such as orientation or focus and dorsomedial prefrontal cortex response signaling. It includes the arrival of a new spatial learning event in the hippocampal brain region.

#### *A.1.6 Event rendering*

For sky this can also include stimulatory parameters that increase the decisionmaking integrity challenge, including parameters such as: sky-to-grand relative volume and types of event, such as fog-cloud-rain particle settings. Similarly, parameters for ground can include: ground illumination intensity, ground volume

#### *The Need for XR-Measurement of Decision-Making Decline and Conscious-State Transition… DOI: http://dx.doi.org/10.5772/intechopen.97384*

and vegetation-variation, vegetation-windspeed events and so on. Keep in mind that virtual reality involving scores and changing scenes can trigger psychological discomfort, dizziness, eye-strain and even addiction [79–81]. For this reason, there should be only one scene with nature-related motion such as wind in grass or tree branch swaying, and water ripples rather than ground buoyancy.

## *A.1.7 3D-Audio*

Parameters that describe the maximum spread of the wavelength field such as fulcrum depth and width can also be used to evaluate conscious-state transition where there are compounding or ageing related deficits in one or both hemispheres. These parameters describe the geometric projection of the user's virtual camera-space and orientation of the player's head rotation and line of direction in the virtual scene. The raycast direction is the parameter used in scripts of assets to report the player's line of direction. The raycast direction describes direction of focus , and is key to describing a change in patient conscious-state. The rate of change of raycast direction is used in behavioral response measurements in recognition and recall of

*Suggestions for Addressing Clinical and Non-Clinical Issues in Palliative Care*

Wavelength intensity can be given for assets in parameters from all assets, including sky and ground, vegetation, weather and wildlife. The parameters can be described as0-1 transparency alpha, depth projection, non-spectral shading component size, reflective source component size, rate of single-asset motion (blur), landscape contrast intensity (sharpness), and scene illumination intensity, whichever is appropriate and convenient to describing striking behavioral response differences. The most critical wavelengths are blue:450–485 nm 620–680 THz 2.64–2.75 eV and red: 625–740 nm 405–480 THz 1.65–2.00 eV on behalf of impact to hippocampal neuronal, and genetic signaling targets involved in transcription/translation feedback loop of CLOCK and BMAL1, and the nucleus basalis magnocellularis projections to the suprachiasmatic nucleus (SCN) mentioned in the main chapter text and shown in **Figure 3**. Cone and melanopsin signaling determines brightness perception. There are references available which suggest that melanopsin excitation takes place at brightness equal to 1 cd <sup>m</sup><sup>2</sup> for an equal-energy-spectrum light at 1

. The maximum range should lie within 380- 780 nm, which represents the

Luminance is in the research to have a defined photon catch of around 480 nm

For this reason, maximum error in the device rendering of luminance should be no more than 10% from this value based on maintaining exactly 480 nm spectrally

Mobile device platform manufacturers have responded to health-risk concerns in reported from excess levels of LED blue-light exposure [76]. On the other hand, the research suggests improvements to these same conditions [77, 78]. For these reasons, timing and duration of a virtual reality monitoring session should be coordinated to start at the first eye-blink, and no longer than three (3) minutes. In fact, the first sampling of sensori-motor response and heart rate should be at the instance of the first patient saccadic (blink). This ensures coordination of the data collection with the timing of innate cognitive recognition such as orientation or focus and dorsomedial prefrontal cortex response signaling. It includes the arrival of

For sky this can also include stimulatory parameters that increase the decisionmaking integrity challenge, including parameters such as: sky-to-grand relative volume and types of event, such as fog-cloud-rain particle settings. Similarly, parameters for ground can include: ground illumination intensity, ground volume

a new spatial learning event in the hippocampal brain region.

range of skylight visible to human bioperception from pre-dawn to post-dusk.

an asset during a nonconscious test.

*A.1.4 Light wavelength calibration*

cd <sup>m</sup><sup>2</sup>

of opsin.

per session.

*A.1.6 Event rendering*

**276**

*A.1.5 Retinal luminance*

Audio settings are vital to immersive realism but, may be varied on left and right, such as for early dementia-related auditory-thalamocortical peri-operative risk evaluation or for patient prescription purposes. Manufacturer settings usually offer sufficient audio control parameters.

#### *A.1.8 Scene bias*

No civil society structures, roads, signs whether semantic or drawings, volumemeasurement, clock-measurement or human relationship and non-nature type cue references should be included in neurobehavioral XR-testing that is intended to predict the condition of neuronal-nucleic cellular health or tissue functioning.

#### *A.1.9 Behavioral sampling*

Thirty second sampling intervals to collect the sensorimotor response and heartrate variation represents successive periods for potential long-term synaptic potentiation in the patient, such as would belong to a learning or decision event based and with matching cerebroarterial blood flow occurring in potential simultaneous XR-fMRI BOLD patient observation. Since daylight variations is composed of wavelengths of light whose frequency and phase change with the position of the sun, it is important to sample for all significant periods of the day in which daylight variation is significant, i.e. the behavioral response from pre-dawn all the way to post-dusk in 3 minute intervals for minimum of 5 or 6 XR-testing sessions, as shown in the sampling tables, below. During an XR-session, wavelight phase information stimulates the retinal cells depending on the device illumination levels (sometimes referred to as *Troland* units, representing retinal illumination from 1mm<sup>2</sup> pupil area exposed to 1cd/m<sup>2</sup> (candelas/m<sup>2</sup> ) of scene light). Light information is translated vibromechanically by the photosensitive retinal ganglion cells onto the suprachiasmatic nuclei cells which directly stimulate the hippocampal neural bed for short-term neuronal growth. The process relies on intracellular transport via light-sensitive heterodimerization which recruits specific proteins in hippocampal neurons, involving recycling endosomes on behalf of neuron axon outgrowth [82]. If XR is used as a circadian prosthetic, this information can be helpful to measuring the amount or volume of full daylight needed for restoring circadian synchronization, using known optogenetic principles of cellular mitochondrial activation and targets in the retinohypothalamic and limbic region circuitry [83].

During a single test event an unconditional stimuli (US) is followed by an unknown conditional stimulus (CS) to the patient, as described in the chapter. This can be for example, a sudden thunder event in a random location that follows the appearance of a bird. The response to the stimuli should be reasonable but significant enough to trigger a cognitive autonomic learning process in healthy controls so that the response behavior is repeated at the next appearance of the same bird, even if the thunder does not occur. In this process, nonconscious autonomic decisionmaking behaviour can be recorded by any XR-scripts that report the raycast change of direction associated with the patient's change of focus and change of heartrate. In Alzheimer's Disease related dementia, for example, there would a
