**Abstract**

Non-voluntary euthanization of dementia patients, the majority of whom are severely conscious-state transition-impaired because of both high levels of antisomnogenic cytokine levels and circadian disruption, indicates the lack of measurement of decision-making decline and conscious-state transition in palliative care settings. This chapter explains why and how to setup medically-meaningful tests to collect these measurements based on environmental-interactive parameters of nonconscious testing in circadian calibrated XR or virtual reality platforms. It also mentions worthy opportunities in relationship to the Human Connectome Project, including the Alzheimer's Disease Connectome Project.

**Keywords:** dementia, euthanization, virtual reality, XR, human connectome project, Alzheimer's Disease, conscious-state transition, decision-making incompetence
