**A.2 Examples of XR-data-collection setup**


Session: Pre-dawn (photopic scene):

Nonconscious asset is animated on the ground level, in a distant, near, left or right start position


Distant: <20,000m virtual radius Near: <1000m virtual radius

Nonconsciousasset Type: Visual and Auditory Animation Type: Approaching Start (blink) US left CS left US left End

*The Need for XR-Measurement of Decision-Making Decline and Conscious-State Transition… DOI: http://dx.doi.org/10.5772/intechopen.97384*


noticeable delay in heartrate variation at the time of change of raycast direction. In mid-day testing, learning and recall decisionmaking might appear to be significantly greater than in dusk-based sessions for a wide variety of dementia related diseases. This is because the pathway between the photosensitive retinoganglion cells to the thalamocortical nuclei may be compromised by the disease, such that the hippocampal cells via the retinohypothalamic tract do not receive sufficient daylight phase management information. The loss of daylight wavelength variation from pre-dawn to post-dusk impairs conscious-state transition and increases patient

*Suggestions for Addressing Clinical and Non-Clinical Issues in Palliative Care*

This requires checking the asset acoustic and animation visibility for distant, near, left and right positions, plus in sky and on ground)

Start End

00:00:00 00:00:30 00:00:60 00:01:05 00:01:10 00:01:30 00:02:00 00:02:05 00:02:00 02:30 03:00

0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1

0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1

0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5

US left CS left US left End

confusion and risk of sleep disruption and hallucination.

**A.2 Examples of XR-data-collection setup**

Note: Patient is standing or seated and stationary at all times.

Session: Control Mid-day (photopic scene): Patient device optimization check Heart rate streaming check.

Distant: <20,000m virtual radius Near: <1000m virtual radius

Nonconsciousasset Type: None Animation Type: None

Sampling interval:

Heart rate variation Sensorimotor response rateleft Sensorimotor response rateright Sky Contrast ratio-left

Sky Contrast ratio-right

Contrast Sky-Ground

Session: Pre-dawn (photopic scene):

Distant: <20,000m virtual radius Near: <1000m virtual radius

> Start (blink)

Nonconsciousasset Type: Visual and Auditory Animation Type: Approaching

**278**

Note: Patient is standing or seated and stationary at all times. Note: Patient is standing or seated and stationary at all times.

Nonconscious asset is animated on the ground level, in a distant, near, left or right start position

Rate of conscious-state transition response Total Cognitive Responsiveness Total Decisionvariation

#### Example Post-Dawn to Mid-day Interval: 4 hours


Sky Contrast ratio-left

Sky Contrast ratio-right

Contrast Sky-Ground

Example Pre-Dusk to Post-Dusk Interval: 20-50 minutes

Note: Patient is standing or seated and stationary at all times.

*DOI: http://dx.doi.org/10.5772/intechopen.97384*

Nonconscious asset is animated on the ground level, in a near left or right start position

US random

Sampling times 00:00:00 00:00:30 00:00:60 00:01:05 00:01:10 00:01:30 00:02:00 00:02:30 00:02:32 02:34 03:00

0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5

0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5

0.2 0.2 0.2 0.8 0.8 0.2 0.2 0.2 0.8 0.2 0.2

CS right US

random

End

Session: Post-dusk (photopic scene)

Start (blink)

Near: <1000m virtual radius

Nonconsciousasset Type: Visual and Auditory Animation Type: Approaching

Heart rate Sensorimotor response rateleft Sensorimotor response rateright Sky Contrast ratio-left

Sky Contrast ratio-right

Rate of conscious-state transition response Total Cognitive Responsiveness Total Decisionvariation

Contrast Sky-to-Ground

Session: Post-dusk (photopic scene)

Start (blink)

Near: <1000m virtual radius

Nonconsciousasset Type Visual and Auditory Animation Type: approaching

Heart rate

**281**

Nonconscious asset is animated on the ground level in a near, left or right start position

US random

Sampling times 00:00:00 00:00:30 00:00:60 00:01:05 00:01:10 00:01:30 00:02:00 00:02:30 00:02:32 02:34 03:00

Note: Patient is standing or seated and stationary at all times.

Rate of conscious-state transition response Total Cognitive Responsiveness Total Decisionvariation

0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5

*The Need for XR-Measurement of Decision-Making Decline and Conscious-State Transition…*

0.5 0.5 0.5 0.8 0.5 0.5 0.5 0.5 0.8 0.5 0.5

0.3 0.3 0.3 0.3 0.8 0.3 0.3 0.3 0.3 0.3 0.3

CS left US

random

End


## *The Need for XR-Measurement of Decision-Making Decline and Conscious-State Transition… DOI: http://dx.doi.org/10.5772/intechopen.97384*


Example Post-Dawn to Mid-day Interval: 4 hours

Note: Patient is standing or seated and stationary at all times.

Retinal illuminance (log Trolands): Photopic > 4.5 /Scotopic 0

Example Mid-day to Pre-dusk Interval: 6 - 8 hours

Note: Patient is standing or seated and stationary at all times.

Nonconscious asset is animated on the sky or ground level, in a near left or right start position

Sampling times 00:00:00 00:00:30 00:00:60 00:01:05 00:01:10 00:01:30 00:02:00 00:02:30 00:02:32 02:34 03:00

Session: Pre-dusk (photopic scene)

Start (blink)

Near: <1000m virtual radius

Nonconsciousasset Type: Visual and Auditory Animation Type: Approaching

Heart rate Sensorimotor response rateleft Sensorimotor response rateright

**280**

Color perception/acuity: Good color vision, high acuity

Start (blink)

Nonconscious asset is animated on the sky level, in a distant, near, left or right start position

*Suggestions for Addressing Clinical and Non-Clinical Issues in Palliative Care*

US left CS left or right

Sampling times 00:00:00 00:00:30 00:00:60 00:01:05 00:01:10 00:01:30 00:02:00 00:02:30 00:02:32 02:34 03:00

0.5 0.5 0.5 0.8 0.8 0.5 0.5 0.5 0.8 0.5 0.5

0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5

0.4 0.4 0.4 0.4 0.4 0.5 0.5 0.5 0.5 0.5 0.5

US left CS left US left End

US left End

Session: Mid-day (no shadow) (photopic scene)

Distant: <20,000m virtual radius Near: <1000m virtual radius Luminance (log cd/m2): 4 to 6 Pupil diameter (mm): 6 to 8

Active photoreceptors: cones

Nonconsciousasset Type: Visual and Auditory Animation Type: Approaching

Heart rate Sensorimotor response rateleft Sensorimotor response rateright Sky Contrast ratio-left

Sky Contrast ratio-right

Rate of conscious-state transition response Total Cognitive Responsiveness Total Decisionvariation

Contrast Sky-to-Ground

## *Suggestions for Addressing Clinical and Non-Clinical Issues in Palliative Care*

Heartrate variation (time of US event recognition) = Heartrate variation (recall

change to a US-trigger (based on change of raycast direction and speed) relative to patient heartrate variation, for dusk versus mid-day and dawn versus mid-day

In general, this could verily indicate a medically-prohibitive gradient for

**non-voluntary patient killing including physician account investigation**

**A.3 Additional evidence-seeking requirements recommended prior to**

Headturn rate or focus > 0 and raycast-direction collides with the CS event

*The Need for XR-Measurement of Decision-Making Decline and Conscious-State Transition…*

if(Physics.Raycast(transform.position, transform.up, hit, 10))

contact = true;

contact = false;

of CS event) And

location of asset

function Update () { var hit : RaycastHit;

*DOI: http://dx.doi.org/10.5772/intechopen.97384*

{

} else {

}

behavioral responses.

**283**

euthanatic administration.


Repeat the above, for Scotopic settings and report.

Compare and analyse daily mid-day decision-variation longitudinal data. Refer to rate of loss of conscious-state transition as: Behavioral range > 0

*The Need for XR-Measurement of Decision-Making Decline and Conscious-State Transition… DOI: http://dx.doi.org/10.5772/intechopen.97384*

Heartrate variation (time of US event recognition) = Heartrate variation (recall of CS event)

And

Sensorimotor response rateleft Sensorimotor response rateright Sky Contrast ratio-left

Sky Contrast ratio-right

Rate of conscious-state transition response Total Cognitive Responsiveness Total Decisionvariation

Contrast Sky-to-Ground

Session: Post-dusk (starry-night scatter) (photopic scene)

Color perception/acuity: No color vision, poor acuity

Start (blink)

Distant: <20,000m virtual radius Near: <1000m virtual radius Luminance (log cd/m2): -6 to -4 Pupil diameter (mm): 7.1 to 6.6

Active photoreceptors: rods

Nonconsciousasset Type: Auditory Animation Type:None

Heart rate Sensorimotor response rateleft Sensorimotor response rateright Sky Contrast ratio-left

Sky Contrast ratio-right

Rate of conscious-state transition response Total Cognitive Responsiveness Total Decisionvariation

**282**

Contrast Sky-to-Ground

Behavioral range > 0

Note: Patient is standing or seated and stationary at all times.

Retinal illuminance (log Trolands): Photopic < -0.62 /Scotopic -4.0 to 0.70

Repeat the above, for Scotopic settings and report.

Refer to rate of loss of conscious-state transition as:

Compare and analyse daily mid-day decision-variation longitudinal data.

Nonconscious asset is auditory in the sky or ground level, in a distant, near, left or right start position

*Suggestions for Addressing Clinical and Non-Clinical Issues in Palliative Care*

US random

Sampling times 00:00:00 00:00:30 00:00:60 00:01:05 00:01:10 00:01:30 00:02:00 00:02:05 00:02:00 02:30 03:00

0 0 0 0 0 0 0 0 0 00

0 0 0 0 0 0 0 0 0 00

0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1

0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5

0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5

0.2 0.2 0.2 0.8 0.8 0.2 0.2 0.2 0.8 0.2 0.2

UC random End

Headturn rate or focus > 0 and raycast-direction collides with the CS event location of asset

```
function Update () {
var hit : RaycastHit;
if(Physics.Raycast(transform.position, transform.up, hit, 10))
        {
              contact = true;
         }
         else
         {
              contact = false;
         }
```
change to a US-trigger (based on change of raycast direction and speed) relative to patient heartrate variation, for dusk versus mid-day and dawn versus mid-day behavioral responses.

In general, this could verily indicate a medically-prohibitive gradient for euthanatic administration.
