**Author details**

Chandrashekhar Devkate<sup>1</sup> \*, Satish Kola<sup>2</sup> , Mohammad Idrees<sup>3</sup> , Naqui J. Siddiqui3 and Roshan D. Nasare<sup>4</sup>

1 Indraraj Arts, Commerce and Science College, Sillod Aurangabad, Maharashtra, India

2 M.G. Arts, Science and Late N.P Commerce College, Armori, Maharashtra, India

3 Department of Chemistry, Institute of Science, Nagpur, Maharashtra, India

4 Department of Chemistry Govt. Science College, Gadchiroli, Maharashtra, India

\*Address all correspondence to: cgdevkate@gmail.com

© 2021 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/ by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

*Eco-Friendly, Green Approach for Synthesis of Bio-Active Novel 3-Aminoindazole Derivatives DOI: http://dx.doi.org/10.5772/intechopen.95565*

### **References**

macromolecules like cytoplasmic membrane covering cytoplasm which acts selective barrier to control internal composition of cell. Amino indazole derivative particularly interrupted such functional roles of cytoplasmic membrane and ionic outflow that resulted cell destruction/death. Synthesized potent bioactive

*Green Computing Technologies and Computing Industry in 2021*

substituted indazole derivatives may open new possibilities in the successful treatment of several diseases due to promising antibacterial profile. So, ample scope exists in further research of this heterocycle especially innate selectivity of these compounds needs to carry out their chemotherapy as potent antibacterial aims to target cell membrane of range of Gram-negative bacteria as to derive novel drugs ofInventive era. Among the synthesized compounds most of the compounds exhibited good to moderate activity against selected strains *S. aureus, P. vulgaris* and *E. coli* while poor activity was evaluated for *S. typhi* (**Figure 5**). This variation in toxicity it may attribute due to union ofdifferent substituent attached to the core 3 aminoindazole which may enhances the biological activities of parent nucleus.

The authors are gratified to, The Director, SAIF, Punjab University, and Chan-

, Mohammad Idrees<sup>3</sup>

Authors are also thankful the Principal, Government Science College, Gadchiroli, for his support and cooperation and also pleased to Dr. Syed Abrar Ahmed and Dr.

1 Indraraj Arts, Commerce and Science College, Sillod Aurangabad, Maharashtra,

2 M.G. Arts, Science and Late N.P Commerce College, Armori, Maharashtra, India

4 Department of Chemistry Govt. Science College, Gadchiroli, Maharashtra, India

© 2021 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/ by/3.0), which permits unrestricted use, distribution, and reproduction in any medium,

3 Department of Chemistry, Institute of Science, Nagpur, Maharashtra, India

HNMR, Mass Spectra, 13C NMR.

, Naqui J. Siddiqui3

**Acknowledgements**

**Conflict of interest**

**Author details**

India

**86**

Chandrashekhar Devkate<sup>1</sup>

and Roshan D. Nasare<sup>4</sup>

digarh for providing, FTIR, CHN analysis, <sup>1</sup>

Mandar Paingankar, for there key assistance.

The authors declare no conflict of interest.

\*, Satish Kola<sup>2</sup>

\*Address all correspondence to: cgdevkate@gmail.com

provided the original work is properly cited.

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*Green Computing Technologies and Computing Industry in 2021*

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[29] Chandrashekhar GD, Ajay MP, Khandu DW, Digambar DG,

nitrate catalyzed highly efficient synthesis of 3-aminoindazole and their antibacterial screening. International journal of research in pharmacy and

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[31] Ahmed K, Shaikh F, Shaheer MM,

[32] Vellaisamy S, J. Carlos M. Cerium (IV) ammonium nitrate as a catalyst in organic synthesis. Chemical Reviews.

Moku B, Shaik B, Rafique M, Siddiqui H, Abdullah A. Convenient synthesis of substituted pyrroles via a cerium (IV) ammonium nitrate (CAN) catalyzed Paal–Knorr reaction. Arabian Journal of Chemistry. 2016;9:542

chemistry.2017;7:513

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2010; 110:3805

Mohammad IMS. Ceric (IV) ammonium

Compounds.2019;1:1

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intramolecular N–N bond formation under mild conditions.Chemical Communications. 2011;47:10133

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3399

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chemistry frontiers. 2018;5:3245

through copper-catalyzed

capture.2013;135:7122

2012;13:3542

2012;68:3851

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Section 4
