**6. Conclusion**

The oxidative stress inducing compounds mediates metabolic process of lipids mainly via peroxidation that leads to the production of macromolecules such as Isoprostane, MDA, 4-HNE in the biological fluids. Moreover, the aldehyde like molecules produced via lipid peroxidation targets and modifies proteins and DNA substantially at macromolecule level. Furthermore, MDA and 4-HNE known to promote cross linking of protein/DNA reactions that significantly alleviates and alters the biomarkers biochemical property, thereby develops a clinical symptomatic states. The use of validated signaling mechanism (s) of Lipid peroxidation and products derived thereof in basic and clinical research as well as in clinical practice has become common place, and their presence as endpoints in clinical trials is now broadly accepted. This knowledge can be used to diagnose disease earlier, or to prevent it before it starts. The signaling markers can be used to improve the efficacy and safety of existing medicines and to develop new medicines.
