**2. Polyherbal (PH)**

The use of herbal medicinal products has become popular for several reasons since they have always been the last order of resort when conventional therapy failed [15, 16]. Majorly, Polyherbal (PH, also known as herbal or traditional medicines) are used as complementary and alternative medicines [17]. The direct and indirect effects of polyherbal (PH) involvement in modulating LPO product formation have attracted scientific debates in recent times [15, 18]. Among the many reasons for use are that they are natural supplements, relatively safe, less toxic, and cheaper [15, 19]. The largest conventional therapy is obtained from plant sources, and many of them are nurtured within the neighborhood [20]. As the usual practice in traditional medicine, any substance or medicinal agent of natural origin may be used alone or with other agents as a polyherbal formulation which often requires less expertise [14]. PH is considered to be supplements and so boycotted major laws [21]. Thus, in most cases, measures for dose regulation are lacking in PH preparations as prohibition is difficult to reach [22]. This makes regulating agencies find it difficult to gather and provide the necessary implementation in many countries of the world. Despite the effort of the World Health Organization (WHO) to issue a certification scheme for the regulation of PH, the problem of non-compliance has been on the high side [23]. To this end, important PH like the *Aloe vera*, ginger, *Curcuma longa*, *Moringa oleifera*, *gingko biloba*, kava, milk thistle among others have birth beneficial compounds. Yet, all of these have been documented and updated for known adverse herb reactions [14, 22, 24]. Some variations in formulations among other factors could further influence the final herbal agents and/or products to be marketed. Reports on the adulteration of PH with conventional agents are grossly available and have raised serious concerns [22, 25]. Thus, the need for new regulations for botanicals has long been overdue. Other possibilities of PH being contaminated with undisclosed molecules around have been suggested to influence long-term consumption [26]. In respect, PH combination is a multifactorial antioxidant with the sole aim of scavenging oxidative radicals [16]. Both natural and synthetic antioxidants compounds abound [21, 27]. LPO products also result in deoxyribonucleic acid, cell membrane, and tissue damages in the human body [1, 2]. The global demand for antioxidants is evident and has prompted scientific interests in searching for new and safe antioxidant substances of natural origin. The WHO report shows both relevant authorities of people living in developing and developed countries have approved the use of traditional medicine for their primary healthcare. Plants possess the innate ability to synthesize a wide variety of enzymatic and non-enzymatic antioxidants capable of attenuating ROS-induced oxidative damage [12]. In respect, using appropriate separation techniques, we can now study the presence of phytoconstituents contributing to the antioxidant property of a given plant mixture [11, 16]. These mixtures may serve as a potential

source of exogenous antioxidants to combat the undesirable effects of oxidative stress. Currently, this forms the basis for the PH that we now witnessed.
