Contents



Preface

This book is a select collection of works on the homology modeling technique,

Molecular modeling by homology is a technique that has been growing and becoming popular in several fields of science such as structural bioinformatics,

Through this tool, it is possible to predict the three-dimensional structure of a protein from its primary sequence of amino acids, as long as there is a threedimensional structure already known of a homologous protein to be used as a

The theoretical models obtained by the homology modeling technique have numerous uses. One is that knowledge of the 3D structure of a protein is crucial for understanding its function and behavior. Thus, theoretical models of proteins are formidable for a good understanding of biological systems and intra- and

This book is aimed at researchers and academic students in areas related to molecular modeling, biotechnology, and molecular biology. It consists of seven

Section 1 contains the introductory chapter (Chapter 1), in which the editor and co-editors of the book make a synthetic and objective approach to the technique of

Section 2 presents two excellent review chapters that address fascinating topics in molecular modeling. Chapter 2 presents the Normal Mode Analysis technique, with examples and excellent didactic-scientific description. Chapter 3 takes a great

In Section 3, readers will be able to find scientific works with in silico experiments that used the modeling technique. This section consists of two chapters, where readers can find practical use in real academic work using molecular protein

Section 4 contains two chapters that address applications associated with modeling.

approach to using force fields to validate three-dimensional models.

Other applications are in the field of biotechnology and drug discovery. Theoretical models of target proteins for drugs or with applicability in genetic engineering can accelerate several discoveries of importance for biotechnological and therapeutic advances. Simulation studies of docking and molecule dynamics using theoretical

theoretical and biochemical chemistry, and computational biophysics.

also called comparative modeling.

extracellular processes of living organisms.

chapters carefully selected and reviewed.

comparative modeling, presenting this tool to the reader.

models have grown enormously.

modeling techniques.

template.

Energy Minimization *by Budhayash Gautam*
