**4. Patients with sickle cell diseases**

Among the genetic disorders, sickle cell disease is the most common around the world. People who are affected are at an increased risk of developing pigmented gallstones [10] and it is said that this risk increases with age. Perioperative and postoperative complications which are mainly vaso-occlusive crises (VOC) may occur as a result of surgeries for symptomatic stones. Minimal risks have been associated with the introduction laparoscopic cholecystectomy because of its advantages over the traditional open surgeries.
