**Abstract**

Two types of predictive models based on artificial neural networks (ANN) and quadratic regression model developed in our laboratory will be summarized in this book chapter. Both models were developed to predict the density, speed of sound, kinematic viscosity and surface tension of amphiphilic aqueous solutions. These models were developed taking into account the concentration, the number of carbons and the molecular weight values. The experimental data were compiled from literature and included different surfactants: i) hexyl, ii) octyl, iii) decyl, iv) tetradecyl and v) octadecyl trimethyl ammonium bromide. Neural models present better adjustment values, with R2 values above 0.902 and AAPD values under 2.93% (for all data), than the quadratic regression models. Finally, it is concluded that the quadratic regression and the neural models can be powerful prediction tools for the physical properties of surfactants aqueous solutions.

**Keywords:** amphiphiles, surfactants, physical properties, modeling, artificial neural network
