**Abstract**

The review is in general try to see some of the major microorganism involved in bioleaching process and studied by different scholars, identify the mechanics and techniques employed to bioleach minerals and factor that enhance or to inhibit the leaching process of microorganism with major reaction taking while bioleaching. Here the methodology and different leaching technique presented with their respected pros and cons, which are commonly employed and reasons behind with justifiable evidences were presented. The values and bioleaching sulfide mineral (copper), precious metal (gold) and radioactive element (uranium) were discussed with some the known producers in the world and finally some highlight given on industrial application of bioleaching.

**Keywords:** bioleaching, leaching techniques, biooxidation, radioactive, pretreatment
