Meet the editor

Dr. Goran Mitulović (ORCID 0000-0003-1964-3965) is the head of the Proteomics Core Facility, Medical University of Vienna. He has more than twenty years of experience developing hardware and analytical methods for multidimensional nano HPLC-MS separation and detection methods for proteins and peptides. He conducted his research with LC Packings/Dionex in Amsterdam; IMP and IMBA in Vienna; and the Medical University of

Vienna. His research interests include mechanistic chromatographic separation of peptides and proteins on different stationary phases (polar, ion-exchange, hydrophobic, and hydrophilic phases), improvement of mass spectrometric response based on the optimized composition of the chromatographic mobile phase, and development of clinical proteomics methods and approaches for use in diagnostics.

Contents

**Section 1**

**Section 2**

**Section 3**

*by Goran Mitulović*

**Preface XI**

Introduction **1**

**Chapter 1 3**

Sample Preparation **9**

**Chapter 2 11**

**Chapter 3 27**

Mass Spectrometry in Clinical Laboratory **53**

**Chapter 4 55**

**Chapter 5 73**

**Chapter 6 99**

Introductory Chapter: A Tool for Aided Advanced Diagnostics

Identification of Peptides and Proteins in Illegally Distributed

*by Ahmad Amini, Torgny Rundlöf, Henrik Lodén, Johan A. Carlsson, Martin Lavén, Ezra Mulugeta, Karin Björk, Torbjörn Arvidsson,* 

Protoporphyrin IX Analysis from Blood and Serum in the Context

*by Anna Walke, Eric Suero Molina, Walter Stummer and Simone König*

Trends in Sample Preparation for Proteome Analysis *by Jakub Faktor, David R. Goodlett and Irena Dapic*

and Deep View into Biological Sample

Products by MALDI-TOF-MS

*Iréne Agerkvist and Anette Perolari*

of Neurosurgery of Glioblastoma

*by Katherine A. Stumpo*

Mass Spectrometry in Clinical Laboratories

*by Jadranka Miletić Vukajlović and Tanja Panić-Janković*

Mass Spectrometry Imaging of Neurotransmitters
