**Author details**

Katherine A. Stumpo University of Scranton, Scranton, PA, USA

\*Address all correspondence to: katherine.stumpo@scranton.edu

© 2020 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/ by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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*Mass Spectrometry Imaging of Neurotransmitters DOI: http://dx.doi.org/10.5772/intechopen.93835*

[1] Caprioli, R.M., Farmer, T.B., Gile, J.: Molecular Imaging of Biological Samples: Localization of Peptides and Proteins Using MALDI-TOF MS. Anal. Chem. 69, 4751-4760 (1997). https://doi. tissue: method challenges and clinical perspectives. Trends Biotechnol. 29, 136-143 (2011). https://doi. org/10.1016/j.tibtech.2010.12.002

[9] Smirnov, I.P., Zhu, X., Taylor, T., Huang, Y., Ross, P., Papayanopoulos, I.A., Martin, S.A., Pappin, D.J.: Suppression of α-Cyano-4-hydroxycinnamic Acid Matrix Clusters and Reduction of Chemical Noise in MALDI-TOF Mass Spectrometry. Anal. Chem. 76, 2958-2965 (2004). https://doi.org/10.1021/ac035331j

[10] Manicke, N.E., Dill, A.L., Ifa, D.R., Cooks, R.G.: High-resolution tissue imaging on an orbitrap mass spectrometer by desorption electrospray ionization mass spectrometry. J. Mass Spectrom. 45, 223-226 (2010). https://

doi.org/10.1002/jms.1707

[11] Wiseman, J., Ifa, D.R., Song, Q., Cooks, R.G.: Tissue Imaging at Atmospheric Pressure Using Desorption Electrospray Ionization (DESI) Mass Spectrometry. Angew. Chemie Int. Ed. 45, 7188-7192 (20016). https://doi. org/10.1002/anie.200602449

[12] Yang, J., Caprioli, R.M.: Matrix sublimation/recrystallization for imaging proteins by mass spectrometry at high spatial resolution. Anal. Chem. 83, 5728-5734 (2011). https://doi.

[13] Leinweber, B.D., Tsaprailis, G., Monks, T.J., Lau, S.S.: Improved MALDI-TOF Imaging Yields Increased Protein Signals at High Molecular Mass. J. Am. Soc. Mass Spectrom. 20, 89-95 (2009). https://doi.org/10.1016/j.

[14] Mainini, V., Bovo, G., Chinello, C., Gianazza, E., Grasso, M., Cattoretti, G., Magni, F.: Detection of high molecular weight proteins by MALDI imaging mass spectrometry. Mol. Biosyst. 9, 1101-1107 (2013). https://doi.

org/10.1021/ac200998a

jasms.2008.09.008

org/10.1039/c2mb25296a

[2] Norris, J.L., Caprioli, R.M.: Analysis of tissue specimens by matrix-assisted laser desorption/ionization imaging mass spectrometry in biological and clinical research. Chem. Rev. 113, 2309- 2342 (2013). https://doi.org/10.1021/

[3] Danbolt, N.C., Zhou, Y., Furness, D.N., Holmseth, S.: Strategies for immunohistochemical protein localization using antibodies: What did we learn from neurotransmitter transporters in glial cells and neurons. Glia. 64, 2045-2064 (2016). https://doi.

[4] Ye, H., Wang, J., Greer, T., Strupat, K., Li, L.: Visualizing Neurotransmitters and Metabolites in the Central Nervous System by High Resolution and High Accuracy Mass Spectrometric Imaging. ACS Chem. Neurosci. 4, 1049-1056 (2013). https://doi.org/10.1021/

[5] Römpp, A., Spengler, B.: Mass spectrometry imaging with high resolution in mass and space, (2013)

[6] Buchberger, A.R., DeLaney, K., Johnson, J., Li, L.: Mass Spectrometry Imaging: A Review of Emerging Advancements and Future Insights,

[7] Trim, P.J., Snel, M.F.: Small

molecule MALDI MS imaging: Current technologies and future challenges. Methods. 104, 127-141 (2016). https:// doi.org/10.1016/j.ymeth.2016.01.011

[8] Seeley, E.H., Caprioli, R.M.: MALDI imaging mass spectrometry of human

**References**

cr3004295

cn400065k

(2018)

org/10.1021/ac970888i

org/10.1002/glia.23027

*Mass Spectrometry Imaging of Neurotransmitters DOI: http://dx.doi.org/10.5772/intechopen.93835*
