**11. Conclusion**

RNA sequencing is an advanced diagnostic aid that serves to be a valuable tool in diagnosis, targeted therapy and prognostic marker for Potentially Malignant Oral Disorders. The technique is highly sensitive and specific and provides valuable information regarding the genomic set up of a particular disease. We have summarized the potential genetic alterations in PMODs and highlighted the research efforts undertaken in order to obtain the RNA profile of the particular disease. The knowledge of RNA profile added with the clinical data can serve to be a diagnostic tool par excellence in detecting Potentially Malignant Oral Disorders.
