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[30] Tabary N, Garcia-Fernandez MJ, Danede F, Descamps M, Martel B, Willart JF. Determination of the glass transition temperature of cyclodextrin polymers. Carbohydrate polymers. 2016;148:172-180. DOI: 10.1016/j. carbpol.2016.04.032

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[32] Pannala R. Impurity Profiling of Solid Oral Drug Products to Sail through GDUFA-II Requirements.

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**129**

**1. Introduction**

**Chapter 7**

*and Beata Kolesińska*

**Abstract**

Modulating the Physicochemical

as a Method of Obtaining

Biodegradable Materials

New Biological Properties of

*Ilona Latańska, Piotr Rosiak, Paulina Paul, Witold Sujka* 

Physical and chemical modifications of chitin and chitosan allow for obtaining new functional properties of the natural polymers. This is a particularly valuable feature for the design and manufacture of new materials for medical applications. Due to their wide and varied biological activity, chitin and chitosan materials are increasingly used as dressing materials with antibacterial and hemostatic properties and as materials accelerating the regeneration of damaged tissues because of stimulation of granulation tissue formation, re-epithelialization and reduction of the formation of scar tissue. In addition, chitosan derivatives have antifungal, antiviral, anticancer activity. The increasing use of chitin and chitosan also has a positive impact on the environment, as it is obtained as a result of chitin deacetylation, usually isolated from shellfish shells. The main source of chitin is waste coating of crustaceans. The annual natural reproducibility of chitin by biosynthesis is estimated at 2–3 billion tons. Our interest in the use of biodegradable biopolymers derived from chitin concerns the design, synthesis in laboratory scale, testing new material properties and the final implementation of new developments for industrial practice of new dressing materials useful in the treatment of bleeding wounds (haemostatic properties) as well as in the regeneration of wounds and ulcers of various etiologies. Examples of chitin-based dressing materials introduced by Tricomed SA are Medisorb R Ag, Medisorb R Membrane, Medisorb R Powder and Tromboguard®.

**Keywords:** chitin, chitosan, chemical modification, biological properties,

Chitin and chitosan belong to the polymeric materials of natural origin from the polysaccharides group. The widely used polysaccharides of natural origin also include cellulose and derivatives of hyaluronic and alginic acid. Use for the production of medical devices (contact with the patient's body), makes them meet several requirements: they should maintain their physicochemical properties after

dressing materials, manufacturing on an industrial scale

Properties of Chitin and Chitosan
