**Author details**

*Chitin and Chitosan - Physicochemical Properties and Industrial Applications*

vapor permeability (transmission of moisture vapor) of min. 400 g/m3

determine their use in many areas, also in medicine.

difficult-to-heal wounds [6–11].

assessed as having a high safety profile [38].

ings based on chitosan on the market.

under Project POIR.04.01.02-00-0004/17.

The authors declare no conflict of interest.

**Acknowledgements**

**Conflict of interest**

market [96, 97].

**5. Conclusion**

Tests of operational parameters: tensile strength, the ability to adapt to the injury site or the transmission of moisture vapors have shown that this dressing has a tensile strength (for porous materials) of min. 75 kPa (according to PN-EN ISO 1798), which corresponds to the value recommended for dressing materials, and

The results of clinical trials have demonstrated the high haemostatic efficacy of Tromboguard®. The high effectiveness and durability of the antihaemorrhagic effect was confirmed 24 hours after application, which allowed the introduction of an absorbent foam dressing [179] and a three-layer hemostatic dressing to the

Chitin and its ester derivatives, as well as chitosan obtained as a result of chitin deacetylation, have many valuable chemical, physical and biological properties that

The widest use of chitin and its derivatives is observed in biomedical sciences, in particular: in dressing materials (active dressings), active substance carriers (drugs and growth factors), in tissue engineering (cell scaffolds - scaffolds, mainly orthopedics) and in regenerative medicine (stem cell differentiation). Chitin accelerates the wound healing process by having a beneficial effect on processes such as angiogenesis, granulation, epithelialization and scar formation, which play a key role in the physiological wound healing process. It increases the inflow of phagocytic cells (segmented granulocytes and macrophages) to the site of infection, stimulates the migration and proliferation of endothelial cells and fibroblasts. Chitin derivative dressings are considered to be very effective medical devices in the healing of

The results of clinical trials with dressings based on butyryl-acetyl chitin co-polyesters have also shown their high effectiveness in healing wounds of various etiologies, mainly those caused by chronic venous insufficiency and diabetes. Their use leads to a reduction in the ulcer area and its depth. These dressings were

On the other hand, the results of clinical trials with chitosan dressings showed high effectiveness and durability of the anti-haemorrhagic effect. These studies also confirmed the safety of the dressing [96]. The antibacterial test confirmed that the dressing is bactericidal. Thus, there are currently many different hemostatic dress-

This research was funded by the National Centre for Research and Development

/24h.

**148**

Ilona Latańska1 , Piotr Rosiak1 , Paulina Paul1 , Witold Sujka1 and Beata Kolesińska2 \*

1 Tricomed S.A., Łódź, Poland

2 Lodz University of Technology, Faculty of Chemistry, Institute of Organic Chemistry, Lodz, Poland

\*Address all correspondence to: beata.kolesinska@p.lodz.pl

© 2021 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/ by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
