**Author details**

Siti Zuhairah Zainuddin and Khuriah Abdul Hamid\* Department of Pharmaceutics, Faculty of Pharmacy, Universiti Teknologi Mara, Cawangan Selangor, Puncak Alam, Malaysia

\*Address all correspondence to: khuriah@uitm.edu.my

© 2021 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/ by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

**67**

*Chitosan-Based Oral Drug Delivery System for Peptide, Protein and Vaccine Delivery*

Maupeu J. Modification of Chitosan for the Generation of Functional Derivatives. Appl Sci. 2019;9(7):1321.

[11] Cheung, R. C., Ng, T. B., Wong, J. H., & Chan WY. Chitosan: An Update on Potential Biomedical and Pharmaceutical Applications. Mar Drugs. 2015;13(8):5156-5186.

[12] Wu, Y., Rashidpour, A., Almajano, M. P., & Metón I. Chitosan-Based Drug Delivery System: Applications in Fish Biotechnology. Polymers (Basel).

[13] Roy, J. C., Salaün, F., Giraud, S., Ferri, A., Chen, G., & Guan J. Solubility of Chitin: Solvents, Solution Behaviors and Their Related Mechanisms. In: Solubility of Polysaccharides. 2017. p.

[14] Sabu Thomas, Anitha Pius SG. Volume 1: Preparation and Properties Elsevier. In: Handbook of Chitin and

[15] Radwan-Pragłowska, J., Piątkowski, M., Deineka, V., Janus, Ł., Korniienko,

Liubchak, I., Zhurba, V., Sierakowska, A., Pogorielov, M., & Bogdał D. Chitosan-Based Bioactive Hemostatic Agents with Antibacterial Properties-Synthesis and Characterization. Molecules. 2019;24(14):2629.

V., Husak, E., Holubnycha, V.,

[16] Foster, L. J., Ho, S., Hook, J., Basuki, M., & Marçal H. Chitosan as a Biomaterial: Influence of Degree of Deacetylation on Its Physiochemical, Material and Biological Properties. PLoS

One. 2015;10(8):e0135153.

Chitosan. 2020. p. 37.

2016;4(3):411-427.

2020;12(5):1177.

110-22.

[10] Elieh-Ali-Komi, D., & Hamblin MR. Chitin and Chitosan: Production and Application of Versatile Biomedical Nanomaterials. Int J Adv Res.

*DOI: http://dx.doi.org/10.5772/intechopen.95771*

[1] Jin, J. F., Zhu, L. L., Chen, M., Xu, H. M., Wang, H. F., Feng, X. Q., Zhu, X. P., & Zhou Q. The optimal choice of medication administration route regarding intravenous, intramuscular, and subcutaneous injection. Patient Prefer adherence. 2015;9:923-942.

[2] Wang, B., Xie, N., & Li B. Influence of peptide characteristics on their stability, intestinal transport, and in vitro bioavailability: A review. J Food

[3] Vela Ramirez, J. E., Sharpe, L. A., & Peppas NA. Current state and challenges in developing oral vaccines. Adv Drug

Biochem. 2018;e12571.

Deliv Rev. 2017;114:116-131.

[4] Cao, S., Xu, S., Wang, H., Ling, Y., Dong, J., Xia, R., &

PharmSciTech. 2019;20(5).

Polysaccharides. 2017.

Sun X. Nanoparticles: Oral Delivery for Protein and Peptide Drugs. AAPS

[5] David L, María CM-O. Chitosan: Strategies to Increase and Modulate Drug Release Rate. Biological Activities and Application of Marine

[6] Mohammed, M. A., Syeda, J., Wasan, K. M., & Wasan EK. An Overview of Chitosan Nanoparticles and Its Application in Non-Parenteral Drug Delivery. Pharmaceutics. 2017;9(4):53.

[7] Muheem, A., Shakeel, F., Jahangir, M. A., Anwar, M., Mallick, N., Jain, G. K., Ahmad FJ. A review on the strategies

peptides and their clinical perspectives. Saudi Pharm J. 2016;24(4):413-428.

[8] Bajracharya, R., Song, J. G., Back, S. Y., & Han HK. Recent Advancements in Non-Invasive Formulations for Protein Drug Delivery. Comput Struct Biotechnol J. 2019;17:1290-1308.

[9] Brasselet, C., Pierre, G., Dubessay, P., Dols-Lafargue, M., Coulon, J.,

for oral delivery of proteins and

**References**

*Chitosan-Based Oral Drug Delivery System for Peptide, Protein and Vaccine Delivery DOI: http://dx.doi.org/10.5772/intechopen.95771*
