**1. Introduction**

436 Type 1 Diabetes – Complications, Pathogenesis, and Alternative Treatments

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Impaired glucose tolerance is a risk factor for cardiovascular disease, but not impaired fasting glucose. The Funagata Diabetes Study. Diabetes Care 22: 920-924 Watford, M. (2002). Small amounts of dietary fructose dramatically increase hepatic glucose Long-chain polyunsaturated fatty acids (LCPUFAs) play an important role in the human body in building up cell membranes and in regulating their fluidity. The most important fatty acids are the essential n-3 fatty acid, alpha-linolenic acid (C18:3n-3, ALA) and the essential n-6 fatty acid, linoleic acid (C18:2n-6, LA), and their most important metabolites, docosahexaenoic acid (C22:6n-3, DHA) and arachidonic acid (C20:4n-6, AA). LCPUFAs are precursors of different eicosanoids, and their availability may be disturbed in several diseases. As insulin is one of the most potent activators of -6 desaturase enzyme, type 1 diabetes mellitus (T1DM) is characterised by the diminished levels of n-3 LCPUFAs (Decsi et al., 2002, 2007; Szabó et al., 2010b).
