**A Novel L-Arginine/L-Glutamine Coupling Hypothesis: Implications for Type 1 Diabetes**

Paulo Ivo Homem de Bittencourt Jr.1,2,3 and Philip Newsholme4

*1Department of Physiology, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul 2Federal University of Rio Grande do Sul School of Physical Education, Porto Alegre, RS 3National Institute of Hormones and Women's Health 4School of Biomolecular and Biomedical Science and Institute for Sport and Health, UCD Dublin, Belfield, Dublin 4 1,2,3Brazil 4Ireland* 
