Meet the editor

Dr. Katherine "Shelly" Dunnington resides and works in the Midwest United States in the state of Kansas. She is a pharmacokineticist with training in pharmaceutical science and cellular or molecular biology and originally was a practicing pharmacist both in hospital and retail settings. She is currently a senior principal scientist in the Data Management and Biometrics department at Celerion, a pharmaceutical contract research

organization. With 21 years in contract research, Dr. Dunnington has many roles in her current position, including training or mentoring scientists; consulting on clinical study design and conduct; analysis, interpretation, and reporting of clinical PK/PD and cardiac safety data; and software validation. Dr. Dunnington holds both a bachelor's degree in pharmacy and an interdisciplinary Ph.D. from the University of Missouri-Kansas City.

Contents

**Section 1**

**Section 2**

Medicine in Diabetes

in Metabolite Profiling

*and Gorrepati Madhavi*

*and María Guadalupe Ortíz-López*

Metabolism of Phytochemicals

*Jitendra Suthar and Selvan Ravindran*

Hepatocytes and Their Role in Metabolism

*Koushlesh Mishra, Pankaj Kashyap and Bhavna Sahu*

*by Benjamin Mann, Roger Melton and David Thompson*

*by Shweta Dutta, Saraswati Prasad Mishra, Anil Kumar Sahu,* 

Drug Metabolism in Drug Discovery and Preclinical Development

From Pharmacogenetics to Gene Expression: Implications for Precision

*by Katy Sánchez-Pozos, María de los Ángeles Granados-Silvestre* 

*by Tanu Dixit, Akash Tiwari, Sneha Bose, Himani Kulkarni,* 

*by Marothu Vamsi Krishna, Kantamaneni Padmalatha* 

*In vitro* Metabolic Stability of Drugs and Applications of LC-MS

**Preface XI**

Introductory Reviews **1**

**Chapter 1 3**

**Chapter 2 19**

Perspectives in Drug Metabolism **33**

**Chapter 3 35**

**Chapter 4 67**

**Chapter 5 77**
