**4. Sedative and hypnotic activity**

Insomnia is a worldwide health issue with different etiology. This condition is treated as self-medication through benzodiazepines, which have a potential side effect of addiction. Once the patient gets addicted, then these medicines are used for life. The natural plant's based tranquilizers might be free of such addiction due to the accumulation of agonist and antagonistic chemical constituents. The hydroalcoholic extract of *P. vera* gum showed a sedative effect in the locomotor test. The extract at the dose of 0.25, 0.5, 1 g/kg showed the increased duration of sleep and shortened sleep latency hypnotic effect in phenobarbital-induced sleep [59].

#### **4.1 Muscle relaxation**

The hydroalcoholic extract of *P. vera* gum acted as muscle relaxant in traction and rotarod test. When tested at 0.25, 0.5, 1 g/kg and only the higher dose (1 g/kg) demonstrated this muscle relaxation effect [59]. No further syudies are available.
