**2.8 Antidiarrheal effect**

The crude methanolic extract of *P. integerrima* significantly reduces the castor oil-induced diarrhea in mice, where maximum relaxation of smooth muscle was noticed. The induced contraction was exerted through calcium and muscarinic receptor agonist. Contraction was inhibited by the plant extract, and this inhibition reflects the plant's antimuscarinic action as well as the calcium channel blocking properties [37]. The crude methanolic effect of *P. integerrima* bark has been tested for its GIT motility effect and showed a significant reduction in induced loos motion [38].
