**5.13 Hepatoprotective effect**

A significant hepatoprotective effect was observed in carbon tetrachlorideinduced hepatitis by the hydroalcoholic extract of *P. vera*. Hepatoprotective effects were observed against CCl4-triggered liver damage in 40 male rats when treated

with *P. vera* hydroalcoholic extract. The antioxidant properties of hydroalcoholic extract potentially supported hepatic cells to suppress inflammation and necrosis caused by CCl4. Findings from this study along with earlier studies confirm that Pistachio extract can act as a potential candidate for liver damage treatment [97]. Another study has been undertaken to ascertain the hepatoprotective effect of the fruit and leaf extracts of *P. lentiscus* on acute hepatitis induced by paracetamol, as evidenced by lowering tissue necrosis, reducing transaminase as well as MDA serum levels. Hepatoprotective capacity against paracetamol (165 mg/kg body weight) toxicity was found in mice pretreated with the same dosage of PL (*Pistacia* leaves) or PF (*Pistacia* fruits) extract (125 mg/kg) or a mixture of both. These findings were verified via histological analysis of the liver, which revealed substantial defense against hepatic necrosis triggered by paracetamol [85].
