**2.5 Anticancer effect**

The crude extract of *P. lenticus* leaves and fruits significantly inhibited the growth of melanoma cell line (B16F10 cells). The leaves and fruits significantly inhibited the B16F10 cells (IC50 = 56.40 and 58.04 μg/mL, respectively) [3], whereas the seed oil and phenolic compounds fraction of *P. lenticus* showed inhibitory potential against BHK21 cell line. The IC50 was 0.029 g/mL and the percent effect was 42.4 at the concentration of 0.09 g/mL [23]. The essential oils extracted from the fruits and leaves of *P. lenticus* were tested for anticancer effect. The oil of leaves exhibited interesting anticancer activity as compared to fruits [16] on RD and L20B cell lines with IC50 values of 26.43 ± 2.18 and 33.02 ± 2.84μg/mL, respectively. A protective effect of the oil of *P. lenticus* has been reported in bleomycin-induced lung fibrosis and oxidative stress in rats [24]. A significant anti- proliferation potential of *P. atlantica* against COLO205 has been noticed along with good antioxidant effect [25]. Colorectal cancer is one of the major malignant forms of cancer, which has been blocked by the essential oil from the *P. palaestina* [26]. The ethanol extract of *P. atlantica* demonstrated a significant effect against the gastric and cervical carcinoma along with antioxidant effect, which is attributed to the presence of phenolic compounds in the extract [27]. The ethyl acetate extract of *P. vera* L. also attenuated the growth of MCF-7 human breast cancer [28]. The anticancer effect of these plants against various cells line is well established. Interestingly, the antiemetic effect of these plants is very good regarding the anticancer effect because most anticancer drugs have emesis as a significant side effect. If a natural remedy has anticancer and antiemetic potential, it might be one of the best therapeutic mixtures.
