**4.4 Anxiolytic effect**

A significant population of the world is affected by anxiety and depression. The chronic use of anxiolytics is responsible for the physical dependence and withdrawal syndrome. To minimize or avoid such harmful effects, the natural plants based treatment might be helpful. The fruits extract of *P. atlantica* demonstrated significant anxiolytic effect in intact and gonadectomized rates [63]. In elevated puls maze animal model the extract of *P. vera* gum showed anxiolytic effect at higher dose (1 g/kg) [59].
