**3.2 Anti- epileptic effect**

Epilepsy is one of the most common, serious neurological conditions, affecting more than 50 million people worldwide. The hydroalcoholic extract of *P. vera* demonstrated a significant anti-epileptic effect in pentylenetetrazole (PTZ) chronic induced kidding in male rats [57]. The epileptic condition was induced by PTZ (40 mg/kg, IP), and the induced condition was significantly inhibited by the extract of *P. vera* at the tested doses of 50 and 100 mg/kg. The inhibition of chronic induced seizure indicate that *P. vera* is a significant antiepileptic. The petroleum ether extract of *P. integerrima* attenuated the PTZ-induced jerks in zebrafish and mice models at the dose of 50 and 100 mg/kg. The antiepileptic effect was further confirmed through maximum electroshock (MES) in a rat model. The tested extract significantly attenuated various aspects of induced jurks [58].
