**2.4 Antiemetic effect**

Emesis is one of the common side effects of numerous drugs. Emesis is also a common problem of other associated diseases. Natural products used for this purpose are well developed traditionally. The copper sulfate and ipecac-induced emesis has been blocked by the *P. vera* leaves and nut extract [22]. Copper sulfate induces emesis through GIT irritation, and ipecac induces emesis through GIT irritation and chemically stimulated the CTZ. The chemical constitutes of ipecac get readily absorbed and interact with 5HT3 and dopamine receptors. A mechanistic study is needed to confirm the extract mode of action.
