**2.12 Anti-osteoarthritis effect**

Osteoarthritis (OA) is one of the chronic health problems around the globe. The patient of OA commonly uses NSAID as self-medication, especially in developing countries. To develop or discover new effective and safe medication for OA, plants' screening is essential. The oleoresin from *P. atlantica* demonstrated a comparable effect with diclofenac in knee osteoarthritis [49]. The *P. atlantica* cream might inhibit various enzymes involved in inflammation. The formulated cream significantly inhibited the OA induced condition. The topical anti-OA is far better than systemic use for the elimination of severe side effects.
