**5. Conclusion**

The study found *E. coli* with most ESBL producing strains. Multiple drug resistance was a common occurrence; in almost all the Gram negative uropathogens characterized, 100% resistance was recorded. ESBL strains generally showed greater resistance than the non-ESBL strains particularly to the cephalosporins and β-lactam antibiotics. However resistance to UTI empirical drugs and other commonly used antibiotics were alike in both ESBL and non-ESBL strains as low susceptibility was observed. An important finding was the considerable resistance of the ESBL strains to the aminoglycosides and imipenem which are last line treatment drugs. The results of the study clearly indicate the need for antimicrobial stewardship and enhanced infection control measures in our hospitals. Routine screening of ESBLs in our hospitals is highly recommended since appropriate antimicrobial therapy can only commence with early detection of these strains.
