**5. Postural correction to treat neurologic disorders by reducing pons-cord tensions**

There have been several clinical controlled trials documenting the association with improved postural parameters (e.g. increasing cervical lordosis, increasing lumbar lordosis, decreasing thoracic hyperkyphosis) translating into improved physiological measures including specific tests indicative of neurologic function [10–16]. These measures include:


*Therapy Approaches in Neurological Disorders*

neurologic symptomatology [74, 75].

compromise neural function is much greater.

unfolding and elastically stretched pons-cord tract (**Figure 7**). With the addition of space occupying lesions, patients having deviations in postural alignment become much more likely to succumb to various pressure mechanisms, or how the nervous

It is important to realize that those patients with poor spinal posture may at times be in positions that are tolerable by the pons-cord tract (i.e. not overstretched), and at other times perform movements that dynamically lengthen the spinal canal causing a pivotal transition to over-stress and over-strain the system (i.e. dynamic stress and strain). Therefore, successful symptomatic relief resulting from postural correction to a patient suffering from neurological complaints may be elucidated. Although some spinal pathologies will not change (e.g. bone spurs), the reduction of forward flexion of the neutral postural position (e.g. increasing cervical/lumbar hypo-lordosis; reducing thoracic hyper-kyphosis) will change the resting, and therefore the dynamic tensions throughout the pons-cord tract sufficiently enough to reduce the tensions from surpassing some pathological tension threshold (maintaining physiologic or normal tensions), and therefore alleviate

How does adverse mechanical tensions within the CNS produce symptoms? Ultimately, pathological CNS tensions affect the vascular supply and therefore the perfusion of the neural tissues or they may affect the actual nerve conduction ability of the nerve cells (causing hyper or hypo function). Mathematically, perfusion = mean arteriole pressure (MAP) – cord interstitial pressure (CIP) [76]. Thus, for perfusion to remain adequate, the MAP must remain greater than CIP. However, as discussed by Harrison et al. [77], an increase in CIP can be caused by at least two forces, a longitudinal force causing unfolding and elastic elongation of the cord, and a transverse force usually by the cord being thrust into the posterior margin of the vertebral body at the anterior portion of the spinal canal. As stated, Stein found that cervical kyphosis, posture subluxation alone is enough to interfere with cord conduction [72], but with an accompanying space occupying lesion the likelihood for a transverse cord/nerve compression pressure mechanism to limit perfusion and

*Left: Cervical kyphosis subluxation in neutral posture results in the unfolding and elastic pre-tension present prior to flexion. Right: Forward flexion of a kyphotic neck may result in 'pathologic' or pons-cord-nerve root tensions that exceed physiologic limits and results in neurologic symptoms; particularly in the presence of a space-occupying lesion such as a bone spur or intervertebral disc prolapse (Courtesy CBP Seminars).*

tissue is compressed upon certain positions and movements.

**56**

**Figure 7.**


### **Figure 8.**

*Central conduction time (N13-N20) also known as spinal cord velocity. In the top figure, a representative example of central conduction time (N13-N20) at three intervals of measurement: baseline, following 10-weeks of treatment, and 1-year follow-up. This is from the study by Moustafa et al. [13] on symptomatic patients with cervical spine disc herniation. Follow correction of the cervical lordosis, a 20% change in central conduction speed is shown in milliseconds (m sec) indicating a faster more efficient response. In the bottom graph a representative sample from the study of Moustafa et al. [78] is shown. Here, in asymptomatic participants, correction of the cervical lordosis and anterior head posture was found to result in a 10% faster response in the central conduction time potential. Comparative and placebo control groups not attaining spine correction showed no improvement in central conduction time.*

### **Figure 9.**

*Dermatomal somatosensory evoked potential (DSSEPs) set up for C6, C7, and C8 nerve root assessment. In (A) Sites of recording: (1) active recording electrode at c3', (2) reference electrode at Fz, and (3) grounding electrode at Fbz. Location of stimulation sites are indicated above: (B) for C6 dermatome, (C) for C7 dermatome, (D) C8 dermatome. Sites of recording. Courtesy of Moustafa et al. [16].*

Here we briefly summarize the particulars of exemplary trials that demonstrate how improvement in targeted spinal and postural parameters have led to improved neurophysiological outcomes.

### **5.1 Central somatosensory conduction time N13-N20**

Using standardized clinical procedures for median nerve stimulation at the wrist, a subjects' central somatosensory conduction time measurement, N13-N20, can be determined. Differences in peak latencies between N13 and N20 is measured as central conduction time or similarly called 'cervical spinal cord velocity'. In 2016, Moustafa et al. reported on a randomized controlled trial using a cervical extension traction orthotic device (Denneroll™; Denneroll Ptdy, limited, Sydney, Australia) in a multimodal rehabilitation program for treating patients with discogenic radiculopathy [13]. Sixty patients were randomized to a treatment and comparison (control) group where both groups received TENS, thoracic spine manipulation, soft tissue mobilization and strengthening exercises. Only the treatment group performed the additional Denneroll orthotic device to increase cervical lordosis and reduce forward head posture. After 30 treatment applications over the course of 10-weeks, only the treatment group demonstrated significant improvements in N13-N20 (20% gain in velocity). Also, at a 1-year follow-up without further intervention, again only the treatment group demonstrated a statistically improved N13-N20 potential. Importantly, only the treatment group receiving the Denneroll had statistically improved cervical lordosis and reduced forward head posture at the 10-week and 1-year follow-up. **Figure 8** (top) demonstrates the improvement in the N13-N20 potential in this trial.

**59**

**Figure 10.**

*The Influence of Sagittal Plane Spine Alignment on Neurophysiology and Sensorimotor Control…*

In another trial, Moustafa et al. reported on the unique treatment of asymptomatic volunteers who had strictly defined anterior head translation and cervical hypolordosis [78]. Eighty persons were randomized into a treatment group who performed cervical extension traction on the Denneroll traction orthotic or a control group who lied on a rolled hydrocollator towel (placebo control). Both groups were treated for 30 sessions over 10-weeks and were then re-assessed after 12 further weeks of no further treatment. Central somatosensory conduction time latency (N13-N20) and amplitudes of spinal (N13), brainstem (P14), parietal (N20 and P27), and frontal (N30) potentials were measured at baseline (prior to treatment), 10-weeks and 22-weeks. After the 10-weeks of treatment, the treatment group had significantly better amplitudes of N13, P14, N20, N27 and N30 as well as central conduction time (10% faster conduction velocity of N13-N20). All significant differences between groups favouring the treatment group remained at the 12-week post-treatment follow-up. Lastly, a statistically significant multiple

*Example of Dermatomal somatosensory evoked potential (DSSEPs) of C6 dermatome at three intervals of measurement. Courtesy of Moustafa et al. [16]. The Pre-treatment DSSEPs from the RCT by Moustafa et al. [16] is shown. In the 10-week post treatment (Follow-up), the DSSEPs following cervical curve correction is shown. Finally, the 3-month (Post) follow-up, DSSEPs are shown where correction was stable over time.*

*DOI: http://dx.doi.org/10.5772/intechopen.95890*

*The Influence of Sagittal Plane Spine Alignment on Neurophysiology and Sensorimotor Control… DOI: http://dx.doi.org/10.5772/intechopen.95890*

### **Figure 10.**

*Therapy Approaches in Neurological Disorders*

neurophysiological outcomes.

**Figure 9.**

**5.1 Central somatosensory conduction time N13-N20**

*dermatome, (D) C8 dermatome. Sites of recording. Courtesy of Moustafa et al. [16].*

Here we briefly summarize the particulars of exemplary trials that demonstrate how improvement in targeted spinal and postural parameters have led to improved

*Dermatomal somatosensory evoked potential (DSSEPs) set up for C6, C7, and C8 nerve root assessment. In (A) Sites of recording: (1) active recording electrode at c3', (2) reference electrode at Fz, and (3) grounding electrode at Fbz. Location of stimulation sites are indicated above: (B) for C6 dermatome, (C) for C7* 

Using standardized clinical procedures for median nerve stimulation at the wrist, a subjects' central somatosensory conduction time measurement, N13-N20, can be determined. Differences in peak latencies between N13 and N20 is measured as central conduction time or similarly called 'cervical spinal cord velocity'. In 2016, Moustafa et al. reported on a randomized controlled trial using a cervical extension traction orthotic device (Denneroll™; Denneroll Ptdy, limited, Sydney, Australia) in a multimodal rehabilitation program for treating patients with discogenic radiculopathy [13]. Sixty patients were randomized to a treatment and comparison (control) group where both groups received TENS, thoracic spine manipulation, soft tissue mobilization and strengthening exercises. Only the treatment group performed the additional Denneroll orthotic device to increase cervical lordosis and reduce forward head posture. After 30 treatment applications over the course of 10-weeks, only the treatment group demonstrated significant improvements in N13-N20 (20% gain in velocity). Also, at a 1-year follow-up without further intervention, again only the treatment group demonstrated a statistically improved N13-N20 potential. Importantly, only the treatment group receiving the Denneroll had statistically improved cervical lordosis and reduced forward head posture at the 10-week and 1-year follow-up. **Figure 8** (top) demonstrates the improvement in the N13-N20 potential in this trial.

**58**

*Example of Dermatomal somatosensory evoked potential (DSSEPs) of C6 dermatome at three intervals of measurement. Courtesy of Moustafa et al. [16]. The Pre-treatment DSSEPs from the RCT by Moustafa et al. [16] is shown. In the 10-week post treatment (Follow-up), the DSSEPs following cervical curve correction is shown. Finally, the 3-month (Post) follow-up, DSSEPs are shown where correction was stable over time.*

In another trial, Moustafa et al. reported on the unique treatment of asymptomatic volunteers who had strictly defined anterior head translation and cervical hypolordosis [78]. Eighty persons were randomized into a treatment group who performed cervical extension traction on the Denneroll traction orthotic or a control group who lied on a rolled hydrocollator towel (placebo control). Both groups were treated for 30 sessions over 10-weeks and were then re-assessed after 12 further weeks of no further treatment. Central somatosensory conduction time latency (N13-N20) and amplitudes of spinal (N13), brainstem (P14), parietal (N20 and P27), and frontal (N30) potentials were measured at baseline (prior to treatment), 10-weeks and 22-weeks. After the 10-weeks of treatment, the treatment group had significantly better amplitudes of N13, P14, N20, N27 and N30 as well as central conduction time (10% faster conduction velocity of N13-N20). All significant differences between groups favouring the treatment group remained at the 12-week post-treatment follow-up. Lastly, a statistically significant multiple

### **Figure 11.**

*Postural stability characteristics were evaluated with a Biodex Balance System SD (BBS) (Biodex Medical Systems, Inc., Shirley, NY). Dynamic balance testing was performed on the unlocked platform to allow free movement concurrently both in the anterior–posterior (AP) and medial-lateral (ML) directions. The platform permits variable levels of resistance to movement perturbation ranging from one to eight (1 being the most restrictive). BBS measures the deviation of each axis during dynamic balance assessments. The BBS software measures an overall stability index (OSI) and is a representative index of balance performance. OSI is the best indicator of the overall ability of the subject to balance the platform whereby a reduced balance or stability correlates with large variation or large value of OSI [79] [80]. From the RCT by Moustafa et al. [10] participants randomized to and achieving cervical spine correction obtained statistically significant improvements in the OSI compared to a standard care group (Pre vs. 10-weeks post vs. 1-year follow up). Courtesy of Moustafa et al. [10, 34].*

regression model to predict central conduction time changes, N13-N20, from correction in cervical lordosis and anterior head translation (AHT) was identified for the intervention group receiving the Denneroll orthotic at both the 10-week mark (p < .001) and the 3-month follow-up (p < .001) [78]. **Figure 8** (bottom) demonstrates the improvement in the N13-N20 potential in this trial.

### **5.2 Dermatomal somatosensory evoked potentials (DSSEPs)**

In 2011, Moustafa et al. reported on the results of a pilot trial that showed patients with cervical spondylotic radiculopathy randomized to a rehabilitation program including cervical spine stretching exercises, infrared radiation and 3-point bending cervical extension traction had significantly improved peak-to-peak amplitude measures of DSSEPs after both 10-weeks of treatment (30 treatment sessions) and at a 12-week follow-up [16]. The comparison (control) group receiving the same treatment less the neck traction did show an initial improvement in DSSEPs after the 10-week treatment period, however, this difference disappeared at the 12-week follow-up. Only the treatment group showed a statistically significant increase in cervical lordosis. Most importantly, Moustafa et al. identified a linear correlation between initial

**61**

**5.3 H-reflex**

**Figure 12.**

*et al. [34].*

*The Influence of Sagittal Plane Spine Alignment on Neurophysiology and Sensorimotor Control…*

DSSEPs and cervical lordosis magnitude for both groups (r = .65; p < 0.0001), whereas this relationship was only maintained in the study group receiving 2-way traction at final follow-up (r = .55; p = 0.033). This indicates that cervical spine lordotic correction linearly correlates to improvements in DSSEPs [16]. **Figures 9** and **10** depict the experimental setup for the DSSEPs of C6, C7, and C8 as well as the changes in C6

*In A, an example of the smooth pursuit neck torsion test (SPNT) is shown neutral, right turn, and left turn of the head indicated by the 45° torso rotated position. Middle and right image: A SPNT test eye velocity is shown as the uneven high amplitude curves. The ciphers indicate the length of the vertical part of the curve between two marks, i.e., the saccades. The forward head posture group (FHP group) has larger errors (*≈*30%) as compared to a match control group with normal head alignment (10% average error). Courtesy of Moustafa* 

As reported in the previous section (5.1), the 2016 trial reported by Moustafa et al. [13] treating patients with discogenic radiculopathy, both groups showed improvements in latency of DSSEPs at the 10-week post-treatment assessments, however only the treatment group showed statistically improved amplitude of DSSEPs. At a 1-year follow-up without intervention, only the treatment group demonstrated statistically improved latency and amplitude of DSSEPs. Also, only the treatment group had improved cervical lordosis and reduced forward head posture

In a unique randomized trial, Moustafa and colleagues [14] investigated the hypothesis that improving the cervical lordosis and reducing forward head translation would improve low back pain, disability, and neurophysiology in a sample of

DSSEPs in the study group receiving the curve corrective traction.

at the 10-week and 1-year follow-up.

*DOI: http://dx.doi.org/10.5772/intechopen.95890*

*The Influence of Sagittal Plane Spine Alignment on Neurophysiology and Sensorimotor Control… DOI: http://dx.doi.org/10.5772/intechopen.95890*

### **Figure 12.**

*Therapy Approaches in Neurological Disorders*

regression model to predict central conduction time changes, N13-N20, from correction in cervical lordosis and anterior head translation (AHT) was identified for the intervention group receiving the Denneroll orthotic at both the 10-week mark (p < .001) and the 3-month follow-up (p < .001) [78]. **Figure 8** (bottom) demon-

*Postural stability characteristics were evaluated with a Biodex Balance System SD (BBS) (Biodex Medical Systems, Inc., Shirley, NY). Dynamic balance testing was performed on the unlocked platform to allow free movement concurrently both in the anterior–posterior (AP) and medial-lateral (ML) directions. The platform permits variable levels of resistance to movement perturbation ranging from one to eight (1 being the most restrictive). BBS measures the deviation of each axis during dynamic balance assessments. The BBS software measures an overall stability index (OSI) and is a representative index of balance performance. OSI is the best indicator of the overall ability of the subject to balance the platform whereby a reduced balance or stability correlates with large variation or large value of OSI [79] [80]. From the RCT by Moustafa et al. [10] participants randomized to and achieving cervical spine correction obtained statistically significant improvements in the OSI compared to a standard care group (Pre vs. 10-weeks post vs. 1-year follow up).* 

In 2011, Moustafa et al. reported on the results of a pilot trial that showed patients

with cervical spondylotic radiculopathy randomized to a rehabilitation program including cervical spine stretching exercises, infrared radiation and 3-point bending cervical extension traction had significantly improved peak-to-peak amplitude measures of DSSEPs after both 10-weeks of treatment (30 treatment sessions) and at a 12-week follow-up [16]. The comparison (control) group receiving the same treatment less the neck traction did show an initial improvement in DSSEPs after the 10-week treatment period, however, this difference disappeared at the 12-week follow-up. Only the treatment group showed a statistically significant increase in cervical lordosis. Most importantly, Moustafa et al. identified a linear correlation between initial

strates the improvement in the N13-N20 potential in this trial.

**5.2 Dermatomal somatosensory evoked potentials (DSSEPs)**

**60**

**Figure 11.**

*Courtesy of Moustafa et al. [10, 34].*

*In A, an example of the smooth pursuit neck torsion test (SPNT) is shown neutral, right turn, and left turn of the head indicated by the 45° torso rotated position. Middle and right image: A SPNT test eye velocity is shown as the uneven high amplitude curves. The ciphers indicate the length of the vertical part of the curve between two marks, i.e., the saccades. The forward head posture group (FHP group) has larger errors (*≈*30%) as compared to a match control group with normal head alignment (10% average error). Courtesy of Moustafa et al. [34].*

DSSEPs and cervical lordosis magnitude for both groups (r = .65; p < 0.0001), whereas this relationship was only maintained in the study group receiving 2-way traction at final follow-up (r = .55; p = 0.033). This indicates that cervical spine lordotic correction linearly correlates to improvements in DSSEPs [16]. **Figures 9** and **10** depict the experimental setup for the DSSEPs of C6, C7, and C8 as well as the changes in C6 DSSEPs in the study group receiving the curve corrective traction.

As reported in the previous section (5.1), the 2016 trial reported by Moustafa et al. [13] treating patients with discogenic radiculopathy, both groups showed improvements in latency of DSSEPs at the 10-week post-treatment assessments, however only the treatment group showed statistically improved amplitude of DSSEPs. At a 1-year follow-up without intervention, only the treatment group demonstrated statistically improved latency and amplitude of DSSEPs. Also, only the treatment group had improved cervical lordosis and reduced forward head posture at the 10-week and 1-year follow-up.

### **5.3 H-reflex**

In a unique randomized trial, Moustafa and colleagues [14] investigated the hypothesis that improving the cervical lordosis and reducing forward head translation would improve low back pain, disability, and neurophysiology in a sample of

### **Figure 13.**

*Sympathetic skin resistance response (SSR). For measurement of the SSR, EMG equipment was used [10]. Active surface electrodes were attached on the palmar side, and the references were placed on the dorsum of the hand. The stimulus was given at the wrist contralateral to the recording side. Measurements were taken from left and right arms. Latencies were measured from the stimulation artifact to the first deflection from the baseline. The amplitude is measured from the peak of the first deflection to the peak of the next one (peak to peak) as shown. Depicted are the results for the study group receiving cervical spine correction (lordosis and forward head posture). On the Top: the study group receiving spine corrective extension traction is shown at pre-study; Middle: after 10 weeks of treatment (30 sessions); and Bottom: at 1-year follow up with no further treatment. Only the group receiving extension traction obtained sagittal plane cervical correction and statistically significant improvement in SSR latency and amplitude. Courtesy of Moustafa et al. [10].*

80 (35 female) patients between 40 and 55 years suffering signs and symptoms from chronic discogenic lumbar radiculopathy (CDLR). Both groups received TENS therapy and hot packs; additionally, the study group received the Denneroll cervical traction orthotic. All treatment interventions were applied at a frequency of 3 x per week for 10 weeks. Both groups were followed for 6 months after their 10-week re-evaluation. Statistically significant differences between the study groups and the control group's postural measures were found favouring improved posture in the Denneroll group for: lumbar lordotic curve (p = .002), thoracic kyphosis (p = .001), trunk inclination (p = .01) and imbalance (p = .001), pelvic inclination (p = .005), and surface rotation (p = 0.01). The two radiographic measures of cervical lordosis (p = .001) and forward head posture (p = .002), and H reflex amplitude (p = .007) and H reflex latency (p = .001) were likewise statistically different between the groups at 10 weeks favoring improvement in the Denneroll study group. Restoring cervical lordosis and reduction of forward head posture with Denneroll traction was found to have a positive impact on 3D posture parameters, leg and back pain

**63**

*The Influence of Sagittal Plane Spine Alignment on Neurophysiology and Sensorimotor Control…*

scores, back disability, and H reflex latency and amplitude. Thus, improvement of sagittal cervical spine posture and alignment benefited the pain, disability, and

In 2013, Moustafa et al. reported the results of a trial employing lumbar extension traction to increase the lumbar lordosis in patients suffering from MRI-verified lumbosacral radiculopathy [15]. Sixty-four patients were randomly allocated to the treatment or comparison (control) group who both received hot packs and interferential therapy; only the treatment group received the lumbar extension traction. After 30 treatment sessions over 10-weeks, only the treatment group showed statistically improved latency and amplitude of the H-reflex. At the 6-month follow-up, again, only the treatment group showed statistically improved H-reflex outcomes. Only the treatment group demonstrated improved lumbar lordosis after the 10-week treatment period and at the

*5.4.1 Cervicocephalic kinesthetic sense measured as head repositioning accuracy*

spine alignment correction has been assessed in three recent randomized trials by the Moustafa et al. group; two of these trials assessed cervical lordotic correction and anterior head translation reduction [10, 79], whereas, one trial assessed improvement in thoracic hyper-kyphosis [11]. In 2017, Moustafa et al. reported on the improvement in HRA, a measurement of cervicocephalic kinesthetic sensibility [79]. Seventy-two patients suffering from cervicogenic dizziness were randomized to a treatment or comparison (control) group and received TENS, hot packs, mobilization, myofascial and suboccipital release, and therapeutic functional exercises. Only the treatment group also received the Denneroll cervical extension traction orthotic device. The cervical range of motion (CROM) device was used to assess cervicocephalic kinesthetic sensibility by measuring the head repositioning average error (*HRA)*. The participants (blindfolded) started with their head in the neutral head position (NHP) and were asked to actively move to the midpoint of their maximum rotation range, which was called the "target position." After returning to the NHP, they were then asked to rotate their head to the target position. The difference between the target position and the achieved position was recorded 3 times and averaged. The midpoint position was used rather than the NHP because it was considered a non-learned position. The CROM device has good criterion validity (*r* = 0.89–0.99) and reliability (intra-class correlation coefficient

Improvement in head repositioning accuracy (HRA) as a result of sagittal plane

After 30 treatment session over 10-weeks, both groups improved on the HRA test [79]. However, at the 1-year follow-up, the treatment group's HRA to the left and right was statistically significantly better than the comparison group. Again, only the treatment group had a statistically improved cervical lordosis and improved forward head posture at both the 10-week and 1-year follow-up. In their more recent [10] randomized trial similar results were identified where improved HRA resulted from improved cervical lordosis and forward head translation reduction; herein, the improvement in the HRA was identified to be linearly correlated to the improvement in both cervical lordosis and reduction in forward head posture. The linear correlation between improved HRA and improved forward head posture magnitude is further supported by the results of a cross-sectional case control investigation which found a linear relationship between worsening HRA and

*DOI: http://dx.doi.org/10.5772/intechopen.95890*

postural imbalances in patients with CDLR.

6-month follow-up.

[ICC] = 0.92–0.96) [80].

increased magnitudes of forward head posture [34].

**5.4 Sensorimotor control measures**

*The Influence of Sagittal Plane Spine Alignment on Neurophysiology and Sensorimotor Control… DOI: http://dx.doi.org/10.5772/intechopen.95890*

scores, back disability, and H reflex latency and amplitude. Thus, improvement of sagittal cervical spine posture and alignment benefited the pain, disability, and postural imbalances in patients with CDLR.

In 2013, Moustafa et al. reported the results of a trial employing lumbar extension traction to increase the lumbar lordosis in patients suffering from MRI-verified lumbosacral radiculopathy [15]. Sixty-four patients were randomly allocated to the treatment or comparison (control) group who both received hot packs and interferential therapy; only the treatment group received the lumbar extension traction. After 30 treatment sessions over 10-weeks, only the treatment group showed statistically improved latency and amplitude of the H-reflex. At the 6-month follow-up, again, only the treatment group showed statistically improved H-reflex outcomes. Only the treatment group demonstrated improved lumbar lordosis after the 10-week treatment period and at the 6-month follow-up.

### **5.4 Sensorimotor control measures**

*Therapy Approaches in Neurological Disorders*

80 (35 female) patients between 40 and 55 years suffering signs and symptoms from chronic discogenic lumbar radiculopathy (CDLR). Both groups received TENS therapy and hot packs; additionally, the study group received the Denneroll cervical traction orthotic. All treatment interventions were applied at a frequency of 3 x per week for 10 weeks. Both groups were followed for 6 months after their 10-week re-evaluation. Statistically significant differences between the study groups and the control group's postural measures were found favouring improved posture in the Denneroll group for: lumbar lordotic curve (p = .002), thoracic kyphosis (p = .001), trunk inclination (p = .01) and imbalance (p = .001), pelvic inclination (p = .005), and surface rotation (p = 0.01). The two radiographic measures of cervical lordosis (p = .001) and forward head posture (p = .002), and H reflex amplitude (p = .007) and H reflex latency (p = .001) were likewise statistically different between the groups at 10 weeks favoring improvement in the Denneroll study group. Restoring cervical lordosis and reduction of forward head posture with Denneroll traction was found to have a positive impact on 3D posture parameters, leg and back pain

*Sympathetic skin resistance response (SSR). For measurement of the SSR, EMG equipment was used [10]. Active surface electrodes were attached on the palmar side, and the references were placed on the dorsum of the hand. The stimulus was given at the wrist contralateral to the recording side. Measurements were taken from left and right arms. Latencies were measured from the stimulation artifact to the first deflection from the baseline. The amplitude is measured from the peak of the first deflection to the peak of the next one (peak to peak) as shown. Depicted are the results for the study group receiving cervical spine correction (lordosis and forward head posture). On the Top: the study group receiving spine corrective extension traction is shown at pre-study; Middle: after 10 weeks of treatment (30 sessions); and Bottom: at 1-year follow up with no further treatment. Only the group receiving extension traction obtained sagittal plane cervical correction and statistically significant improvement in SSR latency and amplitude. Courtesy of Moustafa et al. [10].*

**62**

**Figure 13.**

### *5.4.1 Cervicocephalic kinesthetic sense measured as head repositioning accuracy*

Improvement in head repositioning accuracy (HRA) as a result of sagittal plane spine alignment correction has been assessed in three recent randomized trials by the Moustafa et al. group; two of these trials assessed cervical lordotic correction and anterior head translation reduction [10, 79], whereas, one trial assessed improvement in thoracic hyper-kyphosis [11]. In 2017, Moustafa et al. reported on the improvement in HRA, a measurement of cervicocephalic kinesthetic sensibility [79]. Seventy-two patients suffering from cervicogenic dizziness were randomized to a treatment or comparison (control) group and received TENS, hot packs, mobilization, myofascial and suboccipital release, and therapeutic functional exercises. Only the treatment group also received the Denneroll cervical extension traction orthotic device. The cervical range of motion (CROM) device was used to assess cervicocephalic kinesthetic sensibility by measuring the head repositioning average error (*HRA)*. The participants (blindfolded) started with their head in the neutral head position (NHP) and were asked to actively move to the midpoint of their maximum rotation range, which was called the "target position." After returning to the NHP, they were then asked to rotate their head to the target position. The difference between the target position and the achieved position was recorded 3 times and averaged. The midpoint position was used rather than the NHP because it was considered a non-learned position. The CROM device has good criterion validity (*r* = 0.89–0.99) and reliability (intra-class correlation coefficient [ICC] = 0.92–0.96) [80].

After 30 treatment session over 10-weeks, both groups improved on the HRA test [79]. However, at the 1-year follow-up, the treatment group's HRA to the left and right was statistically significantly better than the comparison group. Again, only the treatment group had a statistically improved cervical lordosis and improved forward head posture at both the 10-week and 1-year follow-up. In their more recent [10] randomized trial similar results were identified where improved HRA resulted from improved cervical lordosis and forward head translation reduction; herein, the improvement in the HRA was identified to be linearly correlated to the improvement in both cervical lordosis and reduction in forward head posture. The linear correlation between improved HRA and improved forward head posture magnitude is further supported by the results of a cross-sectional case control investigation which found a linear relationship between worsening HRA and increased magnitudes of forward head posture [34].

In 2020, Moustafa et al. reported on the improvements in various sensorimotor control measures in patients treated for thoracic hyper-kyphosis [11]. Eighty patients with thoracic hyper-kyphosis were randomized to a treatment or comparison (control) group. Both groups were treated for 30 treatment sessions over a 10-week time period with TENS and hot packs, soft tissue mobilization, thoracic spine manipulation, and functional exercises. Only the treatment group also performed the Denneroll thoracic traction orthotic designed to reduce the thoracic curve. At the 10-week post-treatment assessment, no significant differences were found for left-sided HRA whereas, significant differences favouring the treatment group were found for the right sided HRA. At the 1-year follow-up without intervention, sensorimotor control measurement of HRA, bilaterally, was significantly superior for the intervention group. Also, only the treatment group experienced a reduction in thoracic hyper-kyphosis at the 10-week assessment that was maintained at the 1-year follow-up [11].

### *5.4.2 Biodex balance and stability measurement*

Posture stability efficiency is a key measurement or performance variable of sensorimotor control. In recent randomized trials [10, 11] and case control [34] investigations by Moustafa and colleagues, postural stability characteristics were evaluated with a Biodex Balance System SD (BBS) (Biodex Medical Systems, Inc., Shirley, NY) (**Figure 11**). Dynamic balance testing was performed on the unlocked platform to allow free movement concurrently in both the anterior–posterior (AP) and medial-lateral (ML) directions. The platform permits variable levels of resistance to movement perturbation ranging from one to eight (1 being the most restrictive). BBS measures the deviation of each axis during dynamic balance assessments. The BBS software measures an overall stability index (OSI) and is a representative index of balance performance. OSI is the best indicator of the overall ability of the subject to balance the platform whereby a reduced balance or stability correlates with large variation or large value of OSI [81, 82]. From the RCT by Moustafa et al. [10], participants randomized to and achieving correction of both cervical lordosis and anterior head posture obtained statistically significant improvements in the OSI compared to a standard care group (pre vs. 10-weeks post vs. 1-year follow up). Likewise, in the RCT looking at thoracic hyper-kyphosis reduction, it was found that OSI was statistically improved only in the group achieving reduction of thoracic kyphosis and that this result was stable at 1-year follow-up [11].

The fact that posture stability, as measured with OSI, improves due to correction of the sagittal cervical and thoracic spine alignments seems to make sense; as previously a linearly correlation between worsening OSI and increased magnitudes of forward head posture has been found [34].

### *5.4.3 Smooth pursuit neck torsion test or SPNT*

The smooth pursuit neck torsion test (SPNT) is used to quantify alterations in and improvement in a person's visual-motor control using electro-oculography equipment [83]. **Figure 12** demostrates the SPNT procedure. First, participants perform the SPNT with the head and trunk in the neutral, forward facing posture. Next, while keeping the head facing forward, the torso is placed in a 45° rotation (about a vertical y-axis) position to each side in a consecutive manner. Participants typically perform three blinks of their eyes and are instructed to follow the path of a light source as close as possible with their eyes without movement of their head or neck. The accuracy of the SPNT is determined as the difference between the

**65**

*The Influence of Sagittal Plane Spine Alignment on Neurophysiology and Sensorimotor Control…*

average increase/decrease in the participants NHP vs. the torsioned positions; errors are termed 'corrective saccades' and are reported as a percentage difference from perfect. In a recent case control cohort sample, Moustafa et al. [34] identified that the forward head posture group (FHP group) had larger SPNT errors (≈30%) as compared to a matched control group with normal head alignment (10% average error). In fact, a linear correlation was identified between the magnitude of forward

Importantly, in the Moustafa et al. RCTs [10, 11], SPNT test eye velocity was shown to improve in the group receiving spine correction as compared to the comparison group not receiving and not achieving spine correction. The average SPNT errors in both the cervical spine [10] and the thoracic spine [11] correction groups

Sympathetic skin resistance response (SSR) is a measurement of autonomic nervous system function or dysfunction. For measurement of the SSR, EMG equipment is typically used [10, 34]. Active surface electrodes are attached on the palmar side, and the references are placed on the dorsum of the hand. A stimulus is given at the wrist contralateral to the recording side. Measurements should typically be taken from left and right arms. The SSR is assessed as: (1) a latency measurement from the stimulation artifact to the first deflection from the baseline; and (2) an amplitude is measured from the peak of the first deflection to the peak of the next one (peak to peak). **Figure 13** depicts a typical measurement of SSR latency and

In a recent case–control cohort investigation of 160 asymptomatic volunteers, Moustafa and colleagues [34] investigated the SSR and its relationship to the severity of forward head posture; a strong linear correlation was identified between the magnitude of forward head posture and increased amplitude and latency of the SSR evoked potentials. Thus, increased magnitudes of forward head posture have a negative impact on the autonomic nervous system in essence leading to a state of hyperactivity or increased excitability. Only one RCT on the effects of spine correction on SSR latency and amplitude could be identified. In the study by Moustafa et al. [10], the group receiving spine corrective extension traction obtained sagittal plane cervical correction and statistically significant improvement in SSR latency and amplitude; the results indicated a linear correlation between the amount of correction of the cervical lordosis and FHP and the concomitant improvement of

The above review of sagittal plane spine alignment and its impact on neurophysiology has several strengths. First, there is strong biomechanical evidence indicating that altered and sustained sagittal plane spine and posture alignment results in increasing the stresses and strains acting on the pons-cord tract system and that this impairs directly or indirectly neurophysiology; this evidence has existed since 1960 [8, 9, 26, 68, 69, 71–75, 77]. Second, considering the results of the recent randomized trials reviewed above, it is clear, that rehabilitation techniques that increase the cervical lordosis and lumbar lordosis, have a profound and sustained effect of improving measurements of neurophysiology as measured with DSSEP's, H-Reflex, and central conduction times [12–16, 78, 79]. Similarly, reducing the magnitudes

*DOI: http://dx.doi.org/10.5772/intechopen.95890*

**nervous system**

amplitude.

the SSR potentials [10].

**6. Strengths, applications, and perspectives**

head posture subluxation and the percent error in SPNT.

improved down to bench-mark values for healthy persons (≈10%).

**5.5 Dysafferentation, altered sensorimotor control and autonomic** 

*The Influence of Sagittal Plane Spine Alignment on Neurophysiology and Sensorimotor Control… DOI: http://dx.doi.org/10.5772/intechopen.95890*

average increase/decrease in the participants NHP vs. the torsioned positions; errors are termed 'corrective saccades' and are reported as a percentage difference from perfect. In a recent case control cohort sample, Moustafa et al. [34] identified that the forward head posture group (FHP group) had larger SPNT errors (≈30%) as compared to a matched control group with normal head alignment (10% average error). In fact, a linear correlation was identified between the magnitude of forward head posture subluxation and the percent error in SPNT.

Importantly, in the Moustafa et al. RCTs [10, 11], SPNT test eye velocity was shown to improve in the group receiving spine correction as compared to the comparison group not receiving and not achieving spine correction. The average SPNT errors in both the cervical spine [10] and the thoracic spine [11] correction groups improved down to bench-mark values for healthy persons (≈10%).

### **5.5 Dysafferentation, altered sensorimotor control and autonomic nervous system**

Sympathetic skin resistance response (SSR) is a measurement of autonomic nervous system function or dysfunction. For measurement of the SSR, EMG equipment is typically used [10, 34]. Active surface electrodes are attached on the palmar side, and the references are placed on the dorsum of the hand. A stimulus is given at the wrist contralateral to the recording side. Measurements should typically be taken from left and right arms. The SSR is assessed as: (1) a latency measurement from the stimulation artifact to the first deflection from the baseline; and (2) an amplitude is measured from the peak of the first deflection to the peak of the next one (peak to peak). **Figure 13** depicts a typical measurement of SSR latency and amplitude.

In a recent case–control cohort investigation of 160 asymptomatic volunteers, Moustafa and colleagues [34] investigated the SSR and its relationship to the severity of forward head posture; a strong linear correlation was identified between the magnitude of forward head posture and increased amplitude and latency of the SSR evoked potentials. Thus, increased magnitudes of forward head posture have a negative impact on the autonomic nervous system in essence leading to a state of hyperactivity or increased excitability. Only one RCT on the effects of spine correction on SSR latency and amplitude could be identified. In the study by Moustafa et al. [10], the group receiving spine corrective extension traction obtained sagittal plane cervical correction and statistically significant improvement in SSR latency and amplitude; the results indicated a linear correlation between the amount of correction of the cervical lordosis and FHP and the concomitant improvement of the SSR potentials [10].

## **6. Strengths, applications, and perspectives**

The above review of sagittal plane spine alignment and its impact on neurophysiology has several strengths. First, there is strong biomechanical evidence indicating that altered and sustained sagittal plane spine and posture alignment results in increasing the stresses and strains acting on the pons-cord tract system and that this impairs directly or indirectly neurophysiology; this evidence has existed since 1960 [8, 9, 26, 68, 69, 71–75, 77]. Second, considering the results of the recent randomized trials reviewed above, it is clear, that rehabilitation techniques that increase the cervical lordosis and lumbar lordosis, have a profound and sustained effect of improving measurements of neurophysiology as measured with DSSEP's, H-Reflex, and central conduction times [12–16, 78, 79]. Similarly, reducing the magnitudes

*Therapy Approaches in Neurological Disorders*

that was maintained at the 1-year follow-up [11].

*5.4.2 Biodex balance and stability measurement*

of forward head posture has been found [34].

*5.4.3 Smooth pursuit neck torsion test or SPNT*

In 2020, Moustafa et al. reported on the improvements in various sensorimotor control measures in patients treated for thoracic hyper-kyphosis [11]. Eighty patients with thoracic hyper-kyphosis were randomized to a treatment or comparison (control) group. Both groups were treated for 30 treatment sessions over a 10-week time period with TENS and hot packs, soft tissue mobilization, thoracic spine manipulation, and functional exercises. Only the treatment group also performed the Denneroll thoracic traction orthotic designed to reduce the thoracic curve. At the 10-week post-treatment assessment, no significant differences were found for left-sided HRA whereas, significant differences favouring the treatment group were found for the right sided HRA. At the 1-year follow-up without intervention, sensorimotor control measurement of HRA, bilaterally, was significantly superior for the intervention group. Also, only the treatment group experienced a reduction in thoracic hyper-kyphosis at the 10-week assessment

Posture stability efficiency is a key measurement or performance variable of sensorimotor control. In recent randomized trials [10, 11] and case control [34] investigations by Moustafa and colleagues, postural stability characteristics were evaluated with a Biodex Balance System SD (BBS) (Biodex Medical Systems, Inc., Shirley, NY) (**Figure 11**). Dynamic balance testing was performed on the unlocked platform to allow free movement concurrently in both the anterior–posterior (AP) and medial-lateral (ML) directions. The platform permits variable levels of resistance to movement perturbation ranging from one to eight (1 being the most restrictive). BBS measures the deviation of each axis during dynamic balance assessments. The BBS software measures an overall stability index (OSI) and is a representative index of balance performance. OSI is the best indicator of the overall ability of the subject to balance the platform whereby a reduced balance or stability correlates with large variation or large value of OSI [81, 82]. From the RCT by Moustafa et al. [10], participants randomized to and achieving correction of both cervical lordosis and anterior head posture obtained statistically significant improvements in the OSI compared to a standard care group (pre vs. 10-weeks post vs. 1-year follow up). Likewise, in the RCT looking at thoracic hyper-kyphosis reduction, it was found that OSI was statistically improved only in the group achieving reduction of thoracic kyphosis and that this result was stable at 1-year

The fact that posture stability, as measured with OSI, improves due to correction of the sagittal cervical and thoracic spine alignments seems to make sense; as previously a linearly correlation between worsening OSI and increased magnitudes

The smooth pursuit neck torsion test (SPNT) is used to quantify alterations in and improvement in a person's visual-motor control using electro-oculography equipment [83]. **Figure 12** demostrates the SPNT procedure. First, participants perform the SPNT with the head and trunk in the neutral, forward facing posture. Next, while keeping the head facing forward, the torso is placed in a 45° rotation (about a vertical y-axis) position to each side in a consecutive manner. Participants typically perform three blinks of their eyes and are instructed to follow the path of a light source as close as possible with their eyes without movement of their head or neck. The accuracy of the SPNT is determined as the difference between the

**64**

follow-up [11].

of thoracic hyper-kyphosis [11] and FHP [12–16, 78, 79] has been found in RCT's to result in improved neurophysiological measurements. Finally, clinical management and improvement of several complex neurological disorders have been documented in multiple case reports where spine correction was suggested to be the important variable which improved the patient's neurophysiological disorder [17–25]. Thus, considering the facts that biomechanics studies, randomized trials, and case reports all point to the same finding, clinically and scientifically one would need to concede that improved neurophysiology following correction of the abnormal spine towards normal values is an evidence-based and logical approach to pursue with appropriate patients.

Similarly, the known intimate connections between afferent input (from the proprioceptive, visual and vestibular systems) and stable upright postures of the head and neck [28] and the fact that there exists a plethora of mechanoreceptors in the cervical spine soft tissues providing necessary neurophysiological input in a feed forward and feedback system provides a strong fundamental physiological basis for the concept that altered spine alignment can have a profound effect on sensorimotor control via connections to the vestibular, visual and central nervous systems [29]. Furthermore, and as explicitly stated in the introduction to this chapter, a complex network of neurophysiological connections between cervical spine mechanoreceptors and the sympathetic nervous system exists [30–32]. This information coupled with the findings of both case control investigations [34] and randomized trials [10, 11, 63, 79] provides strong clinical evidence that restoring normal sagittal plane posture and cervical spine alignment is important for a better afferentation process, improved sensorimotor control, and improved autonomic nervous system function.

Clinically, the astute reader should recognize the need to radiographically assess the full spine alignment, in particular the sagittal plane, to identify if a patient is a candidate and in need of true spine correction; that is, structural rehabilitation of the spine and posture. A comparison of the patient's spine and posture should be made against tested normal alignment values such as the Harrison full spine model and posture displacement models discussed herein. Furthermore, the addition of fundamental neurophysiological testing and the basic parts of sensorimotor control measurements should be considered as important assessments during patient evaluations. Once an indication for corrective care has been identified, the clinical administration of specific spine mirror image corrective exercises and extension traction methods should be employed. Previously, we have discussed the techniques, indications and contraindications, timing of, and applications for several known spine corrective methods and the clinician should be willing to add these to their armamentarium for patient care; we refer the reader to this source [35]. Adding the goal and methods of true spine correction to the clinical outcomes of patient care should not be foreign, it should not be in disregard to traditional strength and functional conditioning; it should simply be part of the basic, fundamental treatment approach for abnormalities of the human frame in the effort to improve a variety of spine related and neurophysiological disorders.

### **7. Conclusion**

This chapter has explored the hypothesis and evidence that restoring normal posture and spine alignment has important influences on neurophysiology, sensorimotor control and autonomic nervous system functionality. There is limited but high-quality research identifying that sagittal spine alignment restoration plays an important role in improving neurophysiology, sensorimotor control, and autonomic

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*The Influence of Sagittal Plane Spine Alignment on Neurophysiology and Sensorimotor Control…*

nervous system function. Within the limitations of the fact that only a handful of clinical trials exist on the topics discussed in this chapter, the unique contribution and importance of this review is that it demonstrates that radiographic determined re-alignment of the sagittal spine and posture plays a significant role in long-term management outcomes in people suffering from a variety of musculoskeletal, and health related disorders. Improved neurophysiological function as measured via dermatomal somatosensory evoked potentials, spinal cord velocity (N13-N20 potential), sensorimotor control, and sympathetic nervous system activity is directly influenced by and improved by full spine sagittal alignment in general and, more specifically, to cervical posture and spine alignment. This review identifies main issues that warrant further investigations to elucidate primary interactions and to identify ideal populations that would benefit from structural rehabilitation

PAO is a paid consultant to CBP; DEH teaches spine rehabilitation methods and sells products related to the treatment of spine deformities. IMM has nothing to

*DOI: http://dx.doi.org/10.5772/intechopen.95890*

of the spine and posture techniques as discussed herein.

CDLR Chronic discogenic lumbar radiculopathy

DSSEPs Dermatomal somatosensory evoked potentials

TENS Transcutaneous electrical nerve stimulation

**Conflict of interest**

declare.

**Nomenclature**

AP Anterior–posterior BBS Biodex Balance System SD CBP Chiropractic BioPhysics®

CIP Cord interstitial pressure CNS Central nervous system CROM Cervical range of motion

CTS Carpal tunnel syndrome

MRI Magnetic resonance imaging NHP Neutral head position N13-N20 Central conduction time OSI Overall stability index PD Parkinson's disease

RCT Randomized controlled trial SPNT Smooth pursuit neck torsion SSR Sympathetic skin resistance

THK Thoracic hyper-kyphosis TN Trigeminal neuralgia TS Tourette's syndrome

EMG Electromyography FHP Forward head posture HRA Head repositioning accuracy MAP Mean arteriole pressure

ML Medial-lateral

CSM Cervical spondylotic myelopathy

*The Influence of Sagittal Plane Spine Alignment on Neurophysiology and Sensorimotor Control… DOI: http://dx.doi.org/10.5772/intechopen.95890*

nervous system function. Within the limitations of the fact that only a handful of clinical trials exist on the topics discussed in this chapter, the unique contribution and importance of this review is that it demonstrates that radiographic determined re-alignment of the sagittal spine and posture plays a significant role in long-term management outcomes in people suffering from a variety of musculoskeletal, and health related disorders. Improved neurophysiological function as measured via dermatomal somatosensory evoked potentials, spinal cord velocity (N13-N20 potential), sensorimotor control, and sympathetic nervous system activity is directly influenced by and improved by full spine sagittal alignment in general and, more specifically, to cervical posture and spine alignment. This review identifies main issues that warrant further investigations to elucidate primary interactions and to identify ideal populations that would benefit from structural rehabilitation of the spine and posture techniques as discussed herein.
