**Abstract**

Ocular toxoplasmosis remains to be the most common cause of infectious uveitis in immunocompetent individuals with highly variable prognosis. The transmission mode can be either congenital or acquired. A precise diagnosis of the disease is necessary to opt effective and rapid treatment. While ocular toxoplasmosis usually presents in the classic form, it may as well present in variable clinical spectrum. The diagnosis can be suspected by the ocular inflammatory clinical presentation as well as multimodal imaging. However, serologic tests including intraocular fluid testing may be needed. Treatment includes combination of systemic antiparasitic and antiinflammatory drugs with variable effectivity. More recently, intravitreally antimicrobials may be used. The chapter aims to layout the different clinical presentations and complications of ocular toxoplasmosis. Diagnostic techniques and different antimicrobial combinations for treatment will also be discussed.

**Keywords:** ocular toxoplasmosis, clinical presentation, diagnosis, treatment
