**4.3 Fluconazole**

Fluconazole is a synthetic bistriazole available in oral, topical, and IV preparations. It has good intraocular penetration with low side effect. It shown to have excellent absorption from the gastrointestinal tract. Its plasma concentrations with oral use reach almost the same levels as with intravenous administration. Intraocular Penetration is effective, with aqueous concentrations similar to those in the plasma [74, 79]. Topical 0.2% fluconazole is effective against *Candida* keratitis with deep lesions. Oral fluconazole in a dose of 200 to 400 mg per day effective as an adjuvant with other topical antifungal agents.
