**3. Clinical presentation and differential diagnosis**

Mucopurulent discharge, tearing and foreign body sensation, follicular reaction, conjunctival hyperemia and discharge are the most common symptoms of conjunctivitis. The median time of onset of ocular symptoms is 6 days and the duration of symptoms 3 days.

SARS-CoV2 conjunctivitis can be similar to other viral infections mostly adenoviral. SARS-CoV-2 is usually unilateral and unlike one of adenoviral aethyology, rarely bilateral [16]. The onset in both scenarios is abrupt, injection more severe in adenoviral, similar folicular reaction and chemosis. Petechial hemorrhage, corneal infiltrates and membrane and pseudomembrane formation is more often detected in adenoviral conjunctivitis and discharge is more prominent.

There is a low rate of positive PCR test for SARS-CoV-2 RNA in tears and conjunctival discharge in patients with conjunctivitis presuming the false negativity. Also since the symptoms could be mild and patients do not have visual impairment it can go unnoticed the prevalence can be underestimated.

### **4. Duration and therapy**

The duration of SARS-CoV-2 conjunctivitis is usually 3–4 days and it is a rapid self-limited disease. It ceases with no specific treatment. There are no clinical evidence of efficacy of topical antibotic or corticosteroid therapy. It is sometimes used as a prevention of a bacterial superinfection but it is generaly not recomended. Lubricants, gels and ointments can be used as a symptomatic therapy. Potential sequelae are not yet enough investigated.
