**Acknowledgements**

The authors acknowledge the financial supports from the Shandong First Medical University Talent Introduction Funds (to X.Z.), the Hunan Provincial Hundred Talent Plan (to X.Z.), and the grants from China "863" Plan Project (Grant No. 2014AA020610-1 to XZ).

## **Conflict of interest**

We declare that we have no financial and personal relationships with other people or organizations.
