**3.2 Targeting LCs within the collectively migrating cluster may be a better therapeutic option for the treatment of OC**

As highlighted earlier, the molecular features of LCs are cancer-specific and this represents a challenge for developing clinically relevant therapies against LCs. Despite this, multiple targets have emerged from LCs studies (listed in **Table 1**: Summary of studies investigating LCs profile). These include targeting the LC stimulatory pathways such as the PI3K/mTOR pathway (with tyrosine kinase inhibitors and Ivermectin), metabolic/energy pathways (statins, cardiac glycosides and metformin) and inflammatory pathways (non-steroidal anti-inflammatory drugs).
