**6. Conclusion**

*Ovarian Cancer - Updates in Tumour Biology and Therapeutics*

components, and drug molecules enter deeply into the tumor tissue, where they reach and kill cancer cells. It is noted that this mechanism does not need a physical encounter and contact between the liposome and the cell, where the drug can reach

*This shape represents a Doxil liposome where doxorubicin is confined and encapsulated in the internal* 

There is another example of a nano-drug transporter (micelle) these structures typically contain a more hydrophobic component that helps solubilize/encapsulate therapeutic compounds, while a hydrophilic component provides stability of the assembly in aqueous environments and offers conjugation sites for eventual targeting ligands. This type of nanostructure has been widely used recently, an example being the D-α-tocopheryl polyethylene glycol (PEG) 1000 succinate (TPGS)

It is an amphiphilic water-soluble derivative of natural source vitamin E and PEG, that has been widely employed as a micelle-former biomaterial. Also, it has been reported that TPGS can inhibit the efflux pump that mediates multidrug

*A typical structure of polymeric micelle representing the drug encapsulated and targeting moiety attached.*

and penetrate the barriers that intercept the particles [36].

*compartment where drug molecules are tightly packed.*

**170**

**Figure 5.**

(**Figure 5**) [37].

**Figure 4.**

From the foregoing that nanoparticles are more efficient in the diagnosis and treatment of ovarian cancer as a basic alternative to chemotherapy and a highly efficient pre and postoperative adjuvant due to their great ability to reach the target tissue and high efficiency to stay in vivo for acceptable periods.
