**2.7 LCs are implicated in OC metastasis and invasion**

We have recently identified the OC LCs [37]. A study using spheroid-mesothelium co-culture model was utilised to identify molecules that were specifically expressed at the early stages of invasion via matrix-assisted laser desorption/ ionisation (MALDI) tissue imaging. Among the identified proteins, KRT14 was shown to mark the invading cells universally across the different subtypes of EOC, while KRT14 expression was absent from the normal ovarian and fallopian tube tissue [37]. This study confirmed that cells lacking KRT14 proliferate at the same rate as the WT cells, however, demonstrate significantly impaired migration and matrix-adhesion [37]. These results suggest the explicit role of LCs in invasion and metastasis in OC.
