**5.1 Nanoparticle size**

Naturally, the size of the anti-cancer nanoparticles should be between 10 and 100 nm. This measurement is based on the rates of glomerular sieving of the capillary wall of the kidneys. Research has indicated on size estimates where the

### **Figure 2.**

*Basic nanoparticles used in clinical trials. (a) Nanoparticles composed of therapeutic components. (b) the nanoparticles that are formed from polymer/drug. (c) Nanoparticles that are a liposome component.*

minimum is 10 nanometers as a threshold for renal excretion and where it is known that vessels in tumor cases are subject to leak Macromolecules in a certain way, so the nanoparticles should not be able to circulate for a long time in the bloodstream and have a chance to reach the bloodstream through the vessels of the tumor tissue and enter the tumor tissue where the size of the nanoparticles is greater than 6–12 nm, which is the diameter of the sieve in the blood vessels of normal tissues and It is prevented from entering and not damaging the normal tissue, and it is known that the diameter of the sieve in the tumor blood vessels ranges from 40 to 200 nm (**Figure 3**) [30].
