Meet the editors

Gwo-Yaw Ho is a senior medical oncologist at Monash Health and specialises in treating women with breast and gynaecologic cancer. He has an academic appointment with Monash University, Australia, as a research fellow and was awarded the Monash University, School of Clinical Science Clinician-scientist Fellowship in 2020. He completed his Ph.D. study in 2019 at the Walter and Eliza Hall (WEHI) Institute of Medical Research

whilst practicing as a medical oncologist at the Peter MacCallum Cancer Centre and Royal Women's Hospital, Melbourne. The focus of his research is a subset of highgrade ovarian cancer, including carcinosarcoma, with the poorest outcome which is associated with increased activity of the oncogenic MYCN pathway and the development of pre-clinical cancer models.

Kate Webber is a senior medical oncologist at Monash Health and an adjunct senior lecturer at Monash University, Australia. She has a keen interest in breast and gynaecological oncology, cancer survivorship and clinical trials. She graduated from the University of New South Wales in 2002 with first-class honours and completed her specialty training in medical oncology at St. George and Prince of Wales Hospitals in Sydney. She completed

a Ph.D. in 2016 at the University of New South Wales examining long-term health and psychosocial issues affecting cancer survivors whilst looking at novel models of care for these patients. Dr. Webber is the current co-chair of the Cancer Institute NSW eviQ Medical Oncology Reference Committee.

Contents

**Section 1**

*by Ján Varga*

**Section 2**

**Preface XI**

Ovarian Cancer Genomics **1**

**Chapter 1 3**

**Chapter 2 25**

**Chapter 3 37**

**Chapter 4 53**

**Chapter 5 63**

Ovarian Cancer Surgical Updates **89**

**Chapter 6 91**

**Chapter 7 111**

Genetics and Mutational Landscape of Ovarian Sex Cord-Stromal Tumors *by Trang Nguyen, Trang Minh Tran, Yee Shen Choo, Maria Alexiadis,* 

The Role of Ultra-Radical Surgery in the Management of Advanced

Cytoreductive Procedures and HIPEC in the Treatment of Advanced

*by Bogdan Moldovan, Silviu-Tiberiu Makkai-Popa, Costel Rad,* 

*by Felicia Elena Buruiana, Lamiese Ismail, Federico Ferrari* 

Ovarian Cancer: Molecular Classification and Targeted Therapy

*by Febina Ravindran and Bibha Choudhary*

Ovarian Cancer Tumour Biology: Genesis

Epigenetic Events in Ovarian Cancer

*Peter J. Fuller and Simon Chu*

Ovarian Cancer: State or Art

*and Hooman Soleymani Majd*

*Radu Pisica, Vlad Untaru and Doly Stoica*

Ovarian Cancer

Ovarian Cancer Genetics and the Implications *by Shyamika Mirisse Acharige and Chit Cheng Yeoh*

*by Yanisa Rattanapan and Takol Chareonsirisuthigul*
