**3.5 Anti-helminth, Ivermectin, may be effective in sensitising OC LCs to chemotherapy by disrupting the AKT/mTOR pathway**

Ivermectin belongs to a family of drugs widely used to treat parasites and pest insects [122]. The anti-cancer property of ivermectin can be related to the inhibition of the Pgp pumps and MDR protein expression [123], inhibition of AKT/mTOR pathway [124], and targeting the yes-associated protein 1 (YAP1) [125], all of which are involved in the OC tumorigenesis [100, 126–128]. *In vivo,* ivermectin treatment of a xenograft mouse model of EOC showed a significant reduction in tumour growth and a reversal in tumour growth without severe toxicity effects when the drug was combined with cisplatin [129]. Currently there is a phase II clinical trial in recruitment to study the long-term effect of ivermectin treatment (NCT02366884).
