**10. The significance of** *BRCA* **mutation in HGSOC**

As mentioned earlier in the chapter being positive for *BRCA* mutations when compared with the wild type, gives the ovarian cancer specific features – importantly higher response rate to platinum and other types of non-platinum chemotherapeutic agents [16] and more importantly high sensitivity to Poly(ADP-ribose) polymerase (PARP) inhibitors, which is highly important as a maintenance therapy of the patients who have responded to first line platinum based chemotherapy in improving 5 year disease free survival.
