**Abstract**

Ovarian cancer (OC) is associated with a high rate of resistance to most chemotherapy drugs and thus novel therapies are crucial to overcoming these obstacles. The technological advances in nanotechnology make it possible to adapt these approaches for the treatment of chemo-resistant OC. In parallel, it is also evident that this emerging technology plays crucial roles in other medical areas including wound healing, treatment of viral infection and applications in dentistry. With the advancement of nanotechnology, nano dependent therapies are attractive viable alternatives to conventional therapies for various diseases, especially cancers. Nanoparticles (NPs) are a suitable platform for cytotoxic agent delivery and aiding early diagnosis of disease, which can lead to improving outcomes for these patients. Gas plasma oncotherapy is an innovative modality and shows huge potentials in cancer treatment and may emerge as the fifth cancer treatment modality together with surgery, radiotherapy, chemotherapy, targeted therapy and immunotherapy. The combination of nanoparticle and gas plasma therapy could lead to the discovery of an alternative effective treatment approach in these resistant tumors leading to improvement of OC prognosis. Here, we highlighted the two novel modalities with known multiple biological targets and underlying mechanisms appropriate for their application in OC treatment. This chapter explores the utility of combination or multimodal of novel nanotherapeutic agents in the treatment of OC.

**Keywords:** ovarian cancer (OC), gas plasma, nanoparticles, chemoresistance, reactive oxygen and nitrogen species (RONS), physical effects (UV, EM)
