**4. Conclusion**

Despite the introduction of several novel therapeutics that include targeting DNA repair pathways with Poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi), and vascular endothelial growth factor (VEGF) pathways with bevacizumab, the overall survival outcome for women with platinum-resistant OC remains poor. Unfortunately, women with advanced metastatic OC will eventually succumb to their disease due to the emergence of drug resistance. Understanding the mechanisms of OC migration and metastasis is crucial for the development of an effective therapeutic approach. Targeting the OC LC population serves as an attractive strategy given LCs are instrumental in orchestrating OC spread within the intra-peritoneal cavity. LCs are often highly chemo-resistant due to their stem cell-like nature and their survival post cytotoxic chemotherapy treatment may lead to therapy resistance and tumour recurrence. Multiple potential targets have been identified based on the understanding of LC biology, some of which may be targeted by re-proposing established drugs, such as dual PI3K/mTOR inhibitors, anti-helminths, statins, NSAIDs and metformin. Suppressing and eliminating LCs may be an effective therapeutic option for management of this lethal disease and is worth further exploration.
