**1. Introduction**

Although ovarian cancer (OC) is not the most common cancer, it is the fifth leading cause of cancer deaths among women [1] and accounts for 3–4% of all female cancers. Improvement of therapeutic options in OC patients has improved disease-free survival but has had no significant effect on overall survival. There is still the need for genetic profiling to identify patients who will benefit from anti-angiogenic treatment [2, 3]. Due to the typical disease characteristics, such as initially asymptomatic growth and delayed symptoms, most OC patients are diagnosed at an advanced stage. Early diagnosis at the asymptomatic stage is of paramount importance for survival. Understanding OC development pathways can help with early diagnosis and thus increase the potential of curability as well as screening programs.
