**3.3 Gemcitabine docetaxel combination in BCG naive patients**

Thomas et al. published an abstract of retrospective data for patients receiving sequential gemcitabine and docetaxel. The patients had not received any other intravesical therapy before. They were treated with six weekly instillations of gemcitabine [1 gram of gemcitabine in 50 ml of sterile water] followed immediately by docetaxel [37.5 mg of docetaxel in 50 mL of saline]. Maintenance therapy was then given for two years in patients without recurrence. The total number of patients identified was 30, and the median follow-up was 18 months. The indications of using this combination therapy were advanced age, immunosuppression, and BCG shortage. Treatment success was 96% at three months, 89% at one year, and 89% at two years. Treatment was well tolerated [23].
