*3.1.1 Neoadjuvant setting*

Sousa et al., conducted a pilot clinical trial in 15 patients with intermediate and high-risk non-muscle-invasive bladder cancer patients. HIVEC consisting of eight weekly instillations of intravesical mitomycin C [80 mg in 50 mL] delivered with the novel Combat BRS® system at a temperature of 43°C for 60 min. A total of 119 treatments sessions were given. During TURBT it was found that 8 patients [53%] had a complete response and 7 [47%] had a partial response. The median follow-up was 29 months and the 3-year recurrence rate was 15%. No grade 3 toxicity was observed [18].
