Meet the editors

Dr. Ahmed Lasfar is a Cancer Immunologist and a leading expert on melanoma. He is a full member of the Rutgers-Cancer Institute of New Jersey, principal investigator, and a faculty member at Ernest Mario School of Pharmacy, Rutgers University, New Jersey. Dr. Lasfar's laboratory focuses on understanding the immune mechanisms controlling cancer development and metastasis. In addition to melanoma, Dr. Lasfar's laboratory is studying

hepatocellular carcinoma and breast cancer. Dr. Lasfar has edited several books and research topics in cancer. He is an editor, board member, and reviewer of relevant international journals and foundations. Dr. Lasfar also serves as a consultant scientific adviser for the pharmaceutical industry. Dr. Lasfar obtained his undergraduate and graduate degrees in France from Paris Rene Descartes University and Denis Diderot University. He completed his postdoctoral training in cancer immunology at Robert Wood Johnson Medical School in New Jersey.

Dr. Karine Cohen-Solal is an oncologist with leading expertise in melanoma, having directed a laboratory focused on melanoma research and cell signaling. Currently, she is Director of Medical Strategy, Oncology, at Physicians' Education Resource, New Jersey, and adjunct faculty in the Department of Pharmacology and Toxicology, Rutgers, The State University of New Jersey. Dr. Cohen-Solal graduated from Paris University, France, and

completed her postdoctoral training at Ernest Mario School of Pharmacy, Rutgers. Dr. Cohen-Solal received several awards including a Research Scholar Grant from the American Cancer Society and awards from the New Jersey Commission on Cancer Research and the Melanoma Research Foundation. Dr. Cohen-Solal's breakthroughs involve the identification of a new type of receptor in the genesis of melanoma, the disruption of natural tumor suppressive mechanisms in melanoma development and progression, as well as the role of oncogenic signaling in immune escape mechanisms.

Contents

**Section 1**

Uveal Melanoma

Ocular Melanoma

Anorectal Melanoma

*and Jekaterina Erenpreisa*

and Resistance to Therapy

**Section 2**

**Preface XI**

Types and Categories of Melanoma **1**

**Chapter 1 3**

**Chapter 2 11**

**Chapter 3 33**

**Chapter 4 51**

**Chapter 5 67**

New Advances in the Mechanisms and Treatment of Melanoma **89**

**Chapter 6 91**

**Chapter 7 127**

Introductory Chapter: Melanoma and Therapeutic Perspectives

*by Rahul Gupta, Nalini Bansal, Houssem Ammar and Jyoti Gupta*

Mucosal Melanoma of the Head and Neck: From Diagnosis to Treatment *by Ullyanov Bezerra Toscano de Mendonça, Júlia Guimarães Soffientini,* 

The Role of the Meiotic Component in Reproduction of B-RAF-Mutated

Role of RUNX2 in Melanoma: A New Player in Tumor Progression

*by Karine Cohen Solal and Ahmed Lasfar*

*by Kristina Horkovicova and Alena Furdova*

*by Harika Regani and Santosh G. Honavar*

*Victoria Ficher Barbosa and Keren Cozer*

Melanoma: A Review and "Brainstorming" Session *by Dace Pjanova, Ninel M. Vainshelbaum, Kristine Salmina* 

*by Rachael Pulica, Karine Cohen Solal and Ahmed Lasfar*
