**Author details**

*Melanoma*

like domains 1

**Appendix Table 2.**

*Expression is presented as log2FC units.*

**Gene Symbol Log2FC** Placenta enriched 1 PLAC1 0.669653 Fetal and adult testis expressed 1 FATE1 0.61294

Piwi-like RNA-mediated gene silencing 4 PIWIL4 0.601545 Piwi-like RNA-mediated gene silencing 2 PIWIL2 0.566213 Centrosomal protein 290 CEP290 0.489041 Stromal antigen 2 STAG2 0.470227 Cutaneous T cell lymphoma-associated antigen 1 CTAGE1 0.457364 SSX family member 2 interacting protein SSX2IP 0.426617 Transgelin TAGLN 0.425961 MSANTD3-TMEFF1 readthrough MSANTD3-TMEFF1 0.423834 Tudor domain containing TDRD6 0.344416 ATPase family AAA domain containing 2 ATAD2 0.322527 TTK protein kinase TTK 0.316241 ATPase family AAA domain containing 2B ATAD2B 0.30301 Stromal antigen 1 STAG1 0.277385 OIP5 antisense RNA 1 OIP5-AS1 0.26571 M-phase phosphoprotein 10 MPHOSPH10 0.235959 DDB1- and CUL4-associated factor 12 DCAF12 0.158102

*Significantly upregulated expression of CT antigenes in the cohort of 368 melanoma metastases compared to 103 primary melanomas from the TCGA-SKCM dataset (https://www.cancer.gov/tcga). The data was extracted from the TCGA database using the TCGA Biolinks Bioconductor package [124]. EdgeR [127] was used to perform differential expression analysis through the generalized linear model approach and the differentially expressed genes (DEGs) which were upregulated in metastatic melanoma (log2FC > 0, p < 0.01) were filtered for CT antigens. The CT antigenes list comprising of 220 genes was acquired from the CT database [70].* 

TMEFF1 0.603075

Transmembrane protein with EGF-like and two follistatin-

**108**

Dace Pjanova1 \*, Ninel M. Vainshelbaum1,2, Kristine Salmina1 and Jekaterina Erenpreisa1,2

1 Latvian Biomedical Research and Study Centre, Riga, Latvia

2 Faculty of Biology, University of Latvia, Riga, Latvia

\*Address all correspondence to: dace@biomed.lu.lv

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