**Abstract**

Between 30 and 50% of the world population is permanently colonized in some anatomical site by *Staphylococcus aureus*, although the vast majority are asymptomatic carriers. The nose is its main niche and currently the colonization of *S. aureus* in the pharynx has become relevant due to the variety of reported carrier rates and the epidemiological importance of the dissemination of Methicillin-resistant *S. aureus* strains (MRSA) by pharyngeal carriers. For this bacterium to colonize a tissue successfully, it is necessary to establish many interactions with bacterial and host cell components such as bacterial wall teichoic acids (WTA) with the Scavenger SREC-1 host receptor and at the same time evade the defense mechanisms. On the other hand, there are host factors that will facilitate or complicate the colonization or persistence of *S. aureus* at these sites, such as physiological, genetic, immunological and microbiological factors.

**Keywords:** *Staphylococcus aureus*, colonization, nasopharynx, microbiota, SREC-1
