**6. New staging system**

As the number of HPV-associated OPSCC increased the 7th AJCC staging system lost its ability to differentiate between stages. There was an overlap of survival among different stages of HPV positive oropharyngeal carcinoma. Based on


#### **Table 3.**

*New classification for HPV positive carcinoma oropharynx based on AJCC Cancer Staging Manual, 8th [11].*

accumulating evidence of prognostic value for HPV-positive OPSCC new staging system was refined [5, 10]. The new AJCC 8th staging system for HPV positive oropharyngeal carcinoma is summarized in **Table 3** [11].
