**6. Conclusion**

T1, T2 N1-N2 tumors are treated with concurrent chemoradiation. T3 N0-N2 can be treated either with concurrent chemoradiation or induction chemotherapy followed by reassessment for radical radiation. Patients with T4a N0-N2 (cartilage destruction) disease are treated with surgery followed by postoperative radiotherapy. The treatment for patients with T4b or N3 should be an individualized approach. The decreased treatment outcomes of hypopharyngeal cancers compared to laryngeal cancers are due to advanced stage at presentation disease, poor response to chemoradiation, and difficulty in salvage surgery. An ongoing trial is comparing the effectiveness between the two established organ preservation approaches. The definite role of surgery in organ preservation in locally advanced hypopharyngeal cancers requires further validation. There is no proven data for anti-EGFR or immune checkpoint inhibitors in the radical treatment of locally advanced hypopharyngeal cancers to date and trials are underway.

#### **Conflict of interest**

"The authors declare no conflict of interest."

#### **Notes/thanks/other declarations**

Nil.

*Role of Organ Preservation in Locally Advanced Hypopharyngeal Carcinoma DOI: http://dx.doi.org/10.5772/intechopen.98906*
