**13. Conclusion**

HPV associated oropharyngeal carcinoma is on the rise. A lot of research is happening in this field to refine the best treatment for this separate clinical entity with the vision to reduce long term morbidities. Mature data with long term follow up is needed to change the current practice. At present, HPV-positive oropharyngeal carcinoma patients should not be treated with de-intensification protocols outside the clinical trial setting.
