**4.6 Other treatment options**

Photodynamic Therapy (PDT) is a minimally invasive treatment that involves the activation by light of a drug (photosensitizer) that generates cytotoxic reactive oxygen species. This therapy has been specially studied in cases of premalignant laryngeal lesions. A clinical trial was conducted in 2014 using a compound named 3-(1'-hexyloxyethyl) pyropheophorbide (HPPH) mediated photodynamic therapy [36]. The results of this phase I b trials were very promising with a fewer complications rate. Though this clinical trial is still underway and hence awaiting its approval. Its use in oral cancer lesions, especially for the recurrent ones has been established by many authors [37].
