**2.2 Non-criteria antiphospholipid antibodies**

A series of autoantibodies non included in laboratory classification criteria the so called "non-criteria" aPLs have been reported in the last years related to APS manifestations. Those directed against two major phospholipids-binding protein representing the true antigenic targets for aPL (i.e. prothrombin and β2GPI) have demonstrated the highest significant association with thrombotic and obstetric features of APS [25–27].
