**5. Diagnostic workup for APS**

The initial workup for stroke in the setting of APS is consistent with that of other stroke etiologies. Specifically, a multisystem approach evaluating from "*heart to head*" should be performed. However, in the setting of APS, a *"head to toe"* examination may be more aptly described. Prior to initiating an APS workup, there need to be history and examination findings that begin to clue the diagnostician towards an underlying process related to APS. Such findings, as previously mentioned in Section 2 and to be discussed, are important to consider before initiating an extensive and potentially costly workup. Although, among appropriate patients, APS should be considered in numerous stroke/cerebrovascular settings including acute ischemic infarct, hemorrhagic infarct, cerebral venous sinus thrombosis, and TIA.
