**9. The future perspectives of the clinical use of autoantibodies targeting β2GPI/HLA-DR complexes**

The standard treatment for pregnant women with APS is combination therapy with heparin and low-dose aspirin (LDA) [27], and the same therapy could also be effective in the treatment of women with RPL and anti-β2GPI/HLA-DR positivity. A cohort study is already underway to assess the efficacy of LDA and/or heparin therapy in such women. The history of vascular thrombosis and obstetric complications, including hypertensive disorders of pregnancy and fetal growth restriction, has not been investigated in prospective studies. Future studies assessing whether anti-β2GPI/HLA-DR are associated with thrombosis, hypertensive disorders of pregnancy, and fetal growth restriction are needed.

Further understanding of these novel autoantibodies associated with novel function of HLA class II molecules will provide new insights into the etiology of not only APS but also other autoimmune diseases and might lead to development of new treatment strategies for these diseases.

*A Novel Autoantibody against β2-Glycoprotein I/HLA Class II Complexes in Antiphospholipid… DOI: http://dx.doi.org/10.5772/intechopen.97511*
