*2.1.2 Anticardiolipin antibodies*

aCL are heterogeneous antibodies that in immunoassay's bind to a complex of phospholipids and plasma proteins, mainly β2GPI. In this assay there can be measured two types of aCL, "β2GPI-indipendent" that bind to phospholipids alone and are typically free of clinical significance and "β2GPI-dipendent" which are related to clinical manifestations of APS [19–21].
