**5.4 Treatment**

Adrenal crisis is one of the most serious and life-threatening endocrinological side effect of immunotherapy, which requires prompt diagnosis and treatment. If there is high clinical suspicion of adrenal crisis, after obtaining serum cortisol and ACTH levels, treatment should be started without waiting for the results to come back. Patients should be given stress doses of steroids, IV hydrocortisone 100 mg every six to eight hours and aggressive fluid resuscitation should be made as there is high risk of hypovolemic shock. Endocrinologist consult is highly recommended as well.
