**12.4 AGR2 antibody in early detection**

Since AGR2 expression is an early event in cancer, AGR2 antibodies could be used in early detection through imaging for example. Small foci of eAGR2+ lung or pancreatic tumor can be visualized through binding of labeled chimeric P1G4. The antibody might even eradicate the detected tumors through ADCC and CDC. The iAGR2<sup>+</sup> non-involved lung epithelium would not be detected, and as would AGR2− pancreatic cells. Proposed studies will determine the minimum number of cells in a tumor mass to produce a detectable signal. Given the pg/ml detection levels of our antibodies and the high levels of AGR2 in cancer cells, this potential clinical application is promising. In addition, one could envision a reliable blood test on cancersecreted AGR2 as a means towards cancer detection and disease monitoring.
