Meet the editors

Hilal Arnouk, MD, Ph.D., is an associate professor at the Department of Pathology, Midwestern University, Glendale, Arizona. Dr. Arnouk received his education and post-doctorate training at Roswell Park Cancer Institute, the State University of New York at Buffalo, the Medical College of Georgia, and the University of Alabama at Birmingham. He has directed research studies in academia and biotech industry settings. His major areas of exper-

tise include cancer immunotherapy, biomarker discovery, and precision medicine. Additionally, Dr. Arnouk tremendously enjoys being an educator and a mentor for professional students in the medical and biomedical sciences.

Bassam Abdul Rasool Hassan obtained a Ph.D. in Clinical Pharmacy from the School of Pharmacy, Universiti Sains Malaysia (USM). He worked as a senior lecturer at the Department of Pharmacy, Faculty of Medicine, Universiti Malaya (UM), in 2014–2017, and at the Department of Pharmacy Practice, Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), Shah Alam, Malaysia, in 2017–2019. Dr. Hassan currently works as

a senior lecturer at the Department of Pharmacy, Al-Rafidain University College, Baghdad, Iraq.

Contents

**Section 1**

*Sant P. Chawla and Frederick L. Hall*

to Checkpoint Inhibitors in Cancer

**Preface XI**

Advances in Immuno-Oncology **1**

**Chapter 1 3**

**Chapter 2 29**

**Chapter 3 55**

**Chapter 4 65**

**Chapter 5 77**

**Chapter 6 95**

**Chapter 7 119**

**Chapter 8 139**

Targeted Cancer Therapy Using Nanoparticles and Antibody Fragments

Antibody Therapy Targeting Cancer-Specific Cell Surface Antigen AGR2 *by Alvin Y. Liu, Tatjana Crnogorac-Jurcevic, James J. Lai and Hung-Ming Lam*

*by Rajesh Kumar Yadav, Bandana Kumari, Pritanjali Singh, Asgar Ali,* 

Mathematical Modeling and Dynamics of Oncolytic Virotherapy

Immune and Cell Cycle Checkpoint Inhibitors for Cancer Immunotherapy *by Erlinda M. Gordon, Nicole L. Angel, Ted T. Kim, Don A. Brigham,* 

Evolving Dynamic Biomarkers for Prediction of Immune Responses

*by Afsheen Raza, Maysaloun Merhi, Allan Relecom, Queenie Fernandes,* 

*Varghese Inchakalody, Abdul Rahman Zar Gul, Shahab Uddin,* 

The Endocrinological Side Effects of Immunotherapies

Immunotherapy in Malignant Pleural Mesothelioma

*Mohammed Ussama Al Homsi and Said Dermime*

*by Anush Patel, Haisam Abid and Amrat Kumar*

*by Asako Matsuda and Nobukazu Fujimoto*

*by Sankha Bhattacharya and Kapil Gore*

Advances in Adoptive Cellular Therapy (ACT)

*Sadhana Sharma and Krishnan Hajela*

*by Abdullah Abu-Rqayiq*
