*4.2.2 SPINK1*

The gene that encode serine peptidase inhibitor Kazal type 1 (SPINK1) is found to be associated with CP and commonly observed (40–50%) in tropical pancreatitis, which was referred as fibrocalculous pancreatitis [14]. The variant p.N34S in SPINK1 gene is ten times often in patient with CP compared to normal population [31]. However, the pathophysiologic mechanism is not yet known clearly although it is accepted as a major risk factor for CP.
