**7.** *H. pylori* **gastritis and the possible pathogenic**

#### **7.1 Role of anti-gastric autoimmune reactions**

The serological study in *H. pylori* gastritis provided more indications on the relation between anti gastric autoimmunity and *H. pylori* gastritis. In older patients, *H. pylori* infection is linked to developing anti-parietal cell antibodies [55]. In addition, some *H. pylori*-infected patients, observed 32 years, produce both chronic atrophic gastritis and anti-parietal cell antibodies [104]. These patients eventually become *H. pylori* negative*.* Also Negrini *et al.,* reported on autoantibodies against gastric epithelial cells in up to 84% of *H. pylori* infected subjects [105].

When sera of *H. pylori-infected* subjects were screened for autoantibodies reacting against human gastric tissue by immunohistochemistry, for these autoantibodies two separate binding sites could be seen; The luminal membranes in the antral and corpus mucosa foveolar epithelial cells first and the channel membranes in the gastric corpus mucosa, second in the parietal cells. Antichannel autoanticorps were called the latter type [106].
