**17.4 Macrophage migration inhibitory factor (MIF)**

Macrophage migration inhibitory factor (MIF) is overexpressed in the esophageal mucosa of EoE patients. Recently, in the mice model of EoE, early administration a drug that blocked the action of MIF prevented eosinophilic infiltration in the esophagus. This study can lead to a novel therapy in future if MIF effect can be blocked in EoE patients [55].

The medications investigated for the treatment of EoE can be grouped as follows:

