**3.2 Pharmacokinetic profile of tested ligands**

All the tested compounds obeyed the Lipinski's rule of five (see **Table 1**). From the result of cell permeability using the caco-2 model, estradiol, pinostrobin and tamoxifen showed a great permeability prediction while moderate permeation was observed with catechin, pinobankskin, pinocembrin and gelagin (**Table 1**). Myrecetin, on the other hand showed very poor predicted cell permeability. All studied ligands had good predicted aqueous solubility (log S), and their blood brain barrier prediction, surface area of solvent absorption, predicted number of possible metabolic transformations, as well as polar surface area was within the range set for orally available drugs (see **Table 1**). For the prediction of plasma protein binding, tamoxifen had a score of −7.4, which was not within the stipulated range of −1.5-1.5, howbeit, other ligands had a good plasma protein prediction. Pinostrobin, tamoxifen, estradiol and pinocembrin had high predicted oral bioavailabilities

*3D and 2D molecular interaction of gelagin (a, a1), myrecetin (b, b1) and pinobanksin (c, c1) with crucial amino acids at the ligand binding domain of hER*α*.*

while moderate oral bioavailabilities were observed with Gelagin, pinobanksin, and catechin. Myricetin had the least predicted human oral availability.
