**6. Clinical manifestations**

Graves' Disease is a syndrome which consists of hyperthyroidism, goiter, Graves' orbitopathy, and occasionally a Graves' dermopathy referred to as pretibial or localized myxedema (PTM). High amounts of T4, T3, or both can cause an excessively high metabolic rate. Signs and symptoms of Graves' Disease manifested due to the effect of hypermetabolism as well over stimulation of nervous system by T4, T3 or both.
