**2. Graves' hyperthyroidism**

The clinical manifestation and the laboratory findings aid to establish the diagnosis of Graves' Disease in hyperthyroidism patients. Especially, serum thyrotropin levels is very beneficial marker in hyperthyroidism because secretion is thyrotropin is substantially reduced by small amount of elevation in thyroid secretion. Nevertheless, the diagnosis should be confirmed via the serum free thyroxine measurements [11]. However, in the early periods, only triiodothyronine increase may occur; considering this condition serum free triiodothyronine levels should be examined in the presence of normal serum free thyroxine and low serum thyrotropin concentrations. On the other hand, serum total thyroxine and triiodothyronine measurements are not as reliable as aforementioned markers because the certain drug use may cause elevated values in thyroid hormone–binding proteins. Establishing the diagnosis in a patient with hyperthyroidism is shown here:
