**7. Conclusions**

Diabetic patients are a very high-risk population. The unfavourable anatomy and the prothrombotic state contribute to the poor acute and midterm outcome following percutaneous revascularisations. With the advent of DES, improved stent designs and antiplatelet drugs; the rate of TLR and MACE has also improved in diabetic patients; however, it remains higher in comparison to non-diabetic patients. We have underestimated the impact of atherosclerosis progression in the appearance of late events after PCI, particularly in patients with diabetes. Whilst it is clearly evident that both aggressive secondary prevention and lifestyle modification are mandatory to alter the natural history of CAD in this group, the gold standard for diabetic patient with complex multivessel disease is surgical revascularisation.
