**Abstract**

The simulation and theoretical or numerical predictive modeling of the development and growth of biological tissues mainly in the case of bone is a complicated task. As a result, many and various knowledge tools required (experimental, theoretical and numerical) are not yet mastered and even discovered. We will cite here some techniques and methods as well as results specific to the multi-scale numerical modeling methodology, and multiphysics using finite element coupling with neural network computation of biological tissues applied to the predictive behavior of cortical bone based of the microstructure of their local constituents and their reconstruction according to local mechanobiology. It follows that additional work is necessary to give more precision on the different models, the considered approaches show their potential utility to understand this behavior in terms of biological evolutions as well as the subsequent use in medical applications.

**Keywords:** multiscale, mechanobiology, numerical modeling, coupling, bone
