**4. Bone remodeling**

In compact bone as well as in trabecular bone, bone tissue is constantly renewing [1, 4, 5]. This bone remodeling occurs by successive resorption and formation of bone tissue, a process in which osteoclasts and osteoblasts are closely associated. Bone tissue is renewed about every four months in adults. The renewal mechanism consists of several phases.


differentiate into osteoblasts which synthesize a new Extra Cellular Matrix which is progressively mineralized thereafter. In young, healthy adults, total bone mass remains constant because overall the rates of bone deposition and resorption are equal. The redesign process is not always uniform or balanced:

