**Funding and acknowledgments**

This work was supported by generous funding and operating grants provided to the BioMAT'X R&D&I Group, part of CiiB (Centro de Investigación e Innovación Biomédica at UAndes), through the Faculty of Dentistry and Fondo de Ayuda a la Investigacion FAI - No. **INV-IN-2015-101 (2015–2019)**, Department for Research, Development and Innovation, Universidad de los Andes, Santiago de Chile. The corresponding author wishes to acknowledge supplementary funding provided under the awarded national grants from CORFO-CTecnológicos para la Innovación **#18COTE-89695** (the bioFLOSS project; 2018–2021) and CONICYT-FONDEF Chile **#ID16I10366** (the maxSALIVA project; 2016/17–2020).
