**Notes/thanks/other declarations**

The authors would like to express their sincerest gratitude to all the patients that participated in the implementation studies of CONNECARE and all the volunteers currently testing the CarpeDiem system. We also want to thank all the developers of the system and in particular, Juan Manuel Fernández and Mauricio Gonzales-Gonzales for CONNECARE and Juan Ruiz Zaldivar for CarpeDiem and PAPRIKA. A great thanks also to all the CONNECARE and PAPRIKA consortia as well as the domain experts involved in CarpeDiem.
