**1. Introduction**

The incidence of difficult airway is higher in children with craniofacial syndromes than normal children, hence a thorough airway evaluation is crucial in order to anticipate difficult airway and to formulate a safe plan. Common challenges encountered upon examination of a child's airway include an uncooperative child and the unreliability of the Mallampati scoring for prediction of the difficult airway in children [1]. Airway assessment must focus on the general clinical systematic evaluation as well as the more specific airway issues of each syndrome and other associated organs involvement. The approach should include history taking, physical examination, and diagnostic tests.
