**Chapter 11**

*Bioactive Compounds - Biosynthesis, Characterization and Applications*

[72] Case LB, Waterman CM (2015) Integration of actin dynamics and cell adhesion by a three-dimensional, mechanosensitive molecular clutch. Nat.

[73] Vandenberg CA. Integrins step up the pace of cell migration through polyamines and potassium channels.

[74] Riveline D, Thiagarajan R, Lehn JM,

polyamines: new compounds specific to actin dynamics for mammalian cell and fission yeast. Bio. Architec. 4:144-148.

[75] Sedgwick A, D'Souza-Schorey C (2016) Wnt signaling in cell motility and invasion: drawing parallels between development and cancer. Can. 8:80.

[76] Fujita M, Imadome K, Endo S, Shoji Y, Yamada S, Imai T (2014) Nitric

pancreatic cancer cells via activation of the PI3K–AKT and RhoA pathways after carbon ion irradiation. FEBS Lett.

oxide increases the invasion of

588:3240-3250.

Carlier MF (2014) Synthetic

Cell Biol. 17:955.

ProcNatlAcad Sci. 2008;105(20):7109-7110.

deprivation: a potential therapeutic for cancer cell metastasis? A review. Can.

Abi-Habib R, El-Sibai M (2019) Human recombinant arginase I [HuArgI]- Induced arginine depletion inhibits colorectal cancer cell migration and invasion. Int J. Mol. Sci. 20:6018.

[65] Al-Koussa H, Al-Haddad M,

[66] Morris CR, Hamilton-Reeves J, Martindale RG, Sarav M, Ochoa Gautier

[67] Shan YS, Hsu HP, Lai MD, Yen MC, Chen WC, Fang JH, Weng TY, Chen YL (2015) Argininosuccinate synthetase 1 suppression and arginine restriction inhibit cell migration in gastric can. cell

[68] Spitler R, Schwappacher R, Wu T, Kong X, Yokomori K, Pilz RB, Boss GR, Berns MW (2013) Nitrosyl-cobinamide (NO-Cbi), a new nitric oxide donor, improves wound healing through cGMP/cGMP-dependent protein kinase.

[69] Zhan R, He W, Wang F, Yao Z, Tan J, Xu R, Zhou J, Wang Y, Li H, Wu J (2016) Nitric oxide promotes epidermal stem cell migration via cGMP-Rho GTPase

[70] Sanders MA, Basson MD (2000) Collagen IV-dependent ERK activation in human Caco-2 intestinal epithelial cells requires focal adhesion kinase. J. Biol. Chem. 27538040-27538047.

[71] Rhoads J, Chen W, Gookin J, Wu G, Fu Q, Blikslager A, Rippe R, Argenzio R, Cance W, Weaver E (2004) Arginine stimulates intestinal cell migration through a focal adhesion kinase

dependent mechanism. Gut. 53:514-522.

JB (2017) Acquired amino acid defciencies: a focus on arginine and glutamine. Nutri. Clin. Pract.

Cell Int. 20:150.

32:30S–47S.

lines Sci. Rep. 5:9783.

Cell Sign. 25:2374-2382.

signalling. Sci Rep. 6:30687.

**168**
