**Abstract**

Much lower COVID-19 incidence and mortality in India compared to the Europe and northern America may relate to higher immunity possibly due to the low consumption of fast/packed food, liquour, tobacco, meat, HFSS- high fat, salt, sugar, besides higher exposure and a key blood protein. Indian spice intake is also double the world average and healthy cooking oil use such as Mustard, and may also explain it. Inflammation is the foundation for many ailments and challenges the immunity and vital in non-communicable ailments are at the centre stage in an aeing world. Polypehnols are crucial anti-inflammatory chemicals from spices that can for wellbeing and reduce adverse drug rections. We show this using Arthritis- a chronic auto-immune disorder, with the hlep of pharmacokinetic studies. Molecular Docking study was performed on the key bioactive compounds of important spices regarding COX2 active site (PDB ID 5IKR). Piperine in Black Pepper had most stability (Black Pepper, −9.99 Kcal/mol) followed by 'Apigenin' (Coriander, −9.63), and 'Curcumin' (Turmeric, −8.66) like quercetin in literature, and higher than the methotrexate (−8.6), the standard drug. Hence, their synergistic combination in fat medium such as clarified butter can lead the future drug design.

**Keywords:** Polyphenols, immunity, health, spice, Corona, pharmacokinetic, inflammatory, arthritis

## **1. Introduction**

Spices and herbs have been the key to the health security of the oriental world, besides in western world also until the last century. Polyphenols such as flavanoids are aromatic organic compounds having many health benefits being highly antioxidant in nature [1]. These are vital in preventing chronic or non communicable diseases (NCD) also called as "lifestyle ailments" that are common in the western world [2] and the elderly (over 60 years of age), whose share in the world population is growing rapidly, from 10 to 20% of the total [3].

Inflammation and immunity are most important concepts in medicine today, as cause and remedy respectively [4]. Inflammation is the chief mediator behind chronic or lifestyle ailments prevalent today such as heart disease, cancer, diabetes and blood pressure triggering vigorous research on anti-inflammatory and/or immunity booster phytochemicals, for safety and efficacy (*ibid.*).

Antioxidants are able to reduce oxidative damage to the tissues and protect or restore immunity & health. Vegetarian diet especially fruits, vegetables, pulses are rich in antioxidants, including polyphenols. Spices are among the richest in these, and are anti-inflammatory. Thus, they can be useful to manage immunity disorders such as COVID-19 and Arthritis, an auto-immune disorder of the elderly.

Adverse drug reaction (ADR) is another major concern that spice/herbal medicines can reduce in principle and as experienced, leading to their growing global demand. ADR affects about 5–10% of the patients globally and can cause sever damage/expenses [5]. As spices are permitted food ingredients globally, ADR risk is low.
