**11.1 Optimization of antimalarial therapy with available drugs**

This technique involves mixing existing medications with new dosing regimens or formulations, as well as optimising treatment with currently available drugs. Other non-artemisinin-based combination therapies, in addition to the already proven and recommended artemisinin-based combination therapy, are intended to prevent the development of resistance, improve effectiveness, and tolerability. The idea is to combine two or more drugs with different mechanisms of action, resulting in different molecular targets in the parasite. In an area where *P. falciparum* transmission is endemic and Chloroquine resistance is high, chloroquine combined with sulfadoxine-pyrimethamine demonstrated a large therapeutic return over sulfadoxine-pyrimethamine alone.
