**9.4 Lumefantrine**

Lumefantrine was first synthesised in China in 1976 and is now only used in conjunction with artemether. This mixture is often referred to as a "co-artemether" [86]. Lumefantrine is very lipophilic and has a much longer half-life than artemether, so it's thought to remove any lingering parasites after a combined injection. [No. 29] Lumefantrine has an uncertain molecular weight, but studies indicate that it inhibits the development of -hematin by forming a complex with hemin [87].
