**1. Introduction**

Ribosomes are cellular organelles found in the cytoplasm and primarily responsible for protein synthesis in the cell. Ribosomes' were first observed as dense particles or granules under an electron microscope [1]. The Eukaryote ribosome is a large complex (about 2.6 MDa) molecular machine composed of rRNAs and proteins [2–4]. In the past few years, a combination of X-ray crystallography, NMR spectroscopy and Cryo-electron microscopy has provided new data on the structure of ribosomes [5]. The Eukaryotic ribosome (80S) comprises of two subunits, a large subunit (60S) and small subunit (40S). The ribosome plays a major role during translation of RNA to the various proteins they code for. The process of translation occurs when the message contained in mRNA is decoded and the respective amino

acids synthesized into a growing polypeptide chain which eventually folds into a three dimensional functional structure. Protein synthesis is critical for cell viability, hence highlighting the importance of the ribosome in the cell [6].
