**Abstract**

Determining the structure of the *P. falciparum*40s leads to better understanding of the structural basis for its protein-synthesizing roles in the cell. This enables researchers in the field of drug development to run *in silico* ligand screening experiments using the solved *P. falciparum* 40S structure as a target against a library of potential anti-malarial compounds. Drug leads identified through this method can lead to further biochemical and *In vitro* binding studies with the ultimate goal of developing new class of anti-malarial drugs. The use of structure prediction and modeling technologies in this study dramatically reduces the time it takes from target identification to drug lead determination. Furthermore, very many compounds that were previously incapable of being experimentally tested can now be tested *in silico* against the generated structure. Owing to the increasing utility of bioinformatics and three dimensional structural modeling software, one can accurately build physical models solely from sequence data by unwrapping the information therein on probable motif sites capable of being anchored onto available compounds or aptamers.

**Keywords:** *P. falciparum*, Ribosome, 40S subunit, *In silico*, structure determination, Dynamic simulations, docking
